Showing papers in "Journal of Inorganic Biochemistry in 2008"
TL;DR: By measuring the frequency of each amino acid in metal ion-binding sites, the positive or negative preferences of each residue for each type of cation were identified and may be used for fast identification of metal-binding structural motifs that cannot be identified on the basis of sequence similarity alone.
278 citations
TL;DR: It is hypothesize that these metallodrugs, at variance with classical platinum(II) drugs, produce in most cases their growth inhibition effects through a variety of "DNA-independent" mechanisms, thus providing a solid biochemical basis for the pronounced proapoptotic effects.
241 citations
TL;DR: Five novel metal complexes of the quinolone antibacterial agent ciprofloxacin with Mn(2+), Fe(3+), Co( 2+), Ni(2+) and MoO(2)(2+) have been prepared and characterized with physicochemical, spectroscopic and electrochemical techniques and UV studies of the interaction of the complexes with DNA have shown that these compounds can bind to CT DNA.
220 citations
TL;DR: Spectroscopic studies of the interaction of these tetranuclear clusters with DNA showed that these compounds bind to dsDNA, and all three complexes, at low cluster concentration, are obviously capable of binding to pDNA causing its cleavage (relaxation) at physiological pH and temperature.
220 citations
TL;DR: The role of trivalent arsenicals binding to proteins in arsenic carcinogenesis is presented and some of the protein targets to which arsenite may bind in vivo include tubulin, poly(ADP-ribose)polymerase (PARP-1), thioredoxin reductase, estrogen receptor-alpha, arsenic(+3)methyltransferase and Keap-1.
214 citations
TL;DR: It has been found that the extension of the N-N ligands can increase the stability of the complexes and the in vitro anticancer activities of these compounds are moderate on the five human cancer cell lines screened.
196 citations
TL;DR: A rethink is now needed, with a new emphasis on Fe(III)PPIX in non-aqueous environments that mimic lipids and indeed within the lipid environment itself, which is probably extraordinarily efficient at producing hemozoin.
172 citations
TL;DR: In conclusion, Au(I) and Ag (I) bidendate pyridyl phosphine complexes demonstrate activity against cisplatin-resistant human cancer cells and in vitro cytotoxicity that strongly depends upon their lipophilicity.
166 citations
TL;DR: Investigations of 2-deoxy-d-ribose (DR) oxidation catalyzed by each of those complexes, using 2-thiobarbituric acid reactive species (TBARS) method, and detection of reactive oxygen species (ROS) formation by spin-trapping EPR, suggested that their mechanism of action in performing efficiently DNA cleavage occurs preferentially, but not only by oxidative pathways.
157 citations
TL;DR: A novel Ru(III) complex, mer-[RuCl(3)(CH(3)CN)(dpq)] (1), has been synthesized and characterized by X-ray diffraction, where dpq=dipyrido[3,2-d:2',3'-f]quinoxaline and it has been found that the stability in buffered solutions and the reduction potential for the Ru(II) couple can be modulated by changing the small molecule bonded to
TL;DR: In this paper, a series of copper(II) and zinc (II) complexes involving a tridentate O,N,O'-donor Schiff base derived from salicylaldehyde and beta-alanine is presented.
TL;DR: It is found that nitric oxide dissociates from ferrous neuroglobin much faster than previously appreciated, consistently with the decay of the Fe(II)-NO product during the reaction.
TL;DR: Preliminary data indicates that metal complexes targeted at parasite cysteine proteases show promise for the treatment of both Chagas' disease and leishmaniasis.
TL;DR: The tetradentate ntb and its trigonal bipyramidal cobalt( II) and zinc(II) compounds were active, regardless of the anion present in the complex, and showed a wide range of activity towards Gram(+) and Gram(-) microorganisms.
TL;DR: The next big advance in platinum-based chemotherapy is not likely to come from the development of new drugs, but from the controlled and targeted delivery of already approved drugs or those in late stage clinical trials.
TL;DR: The trend in DNA-binding affinities, the spectral properties as well as the interesting phenomena of larger extent of hypochromism but relatively smaller K(b) values for the title complexes have been reasonably explained.
TL;DR: The manganese complexes showed a significant growth inhibition of the dermatophytes tested and fungi of the genus Scedosporium as these fungi are usually poorly susceptible to current antifungal including Amphotericin B and Itraconazole chosen as reference in this study.
TL;DR: The thermal denaturation and viscosity binding data suggest DNA surface and/or groove binding nature of the complexes, and poor chemical nuclease activity in dark in the presence of 3-mercaptopropionic acid (MPA) or hydrogen peroxide.
TL;DR: Hydrolysis is suppressed at high chloride concentrations, which has important implications on the mode of action of the RAPTA drug candidates.
TL;DR: This review focuses on the mechanisms underlying iron uptake by the Pvd pathway in pseudomonads, taking into account recent biochemical and biophysical studies and recently solved 3D-structures of the PvD outer membrane transporter FpvA in four different loading states.
TL;DR: The Cu(sparfloxacinato)(N-donor)Cl complexes are among the most active ones against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, when compared to the other corresponding copper-quinolone complexes studied by the group and their antimicrobial activity is increased in the order bipyam
TL;DR: Kinetic measurements revealed first-order dependence on the catalyst and dioxygen concentration and saturation type behavior with respect to the corresponding substrate and it was found that the added triethylamine in both systems accelerates the reaction.
TL;DR: The reactions of arene-metal complexes, including 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decanephosphine (pta) and chloro co-ligands, with 9-methylguanine, adenine, and a series of nucleosides were studied in water to ascertain the binding modes.
TL;DR: If amylin amyloid is cytotoxic to beta-cells then Cu(II) should protect against the degeneration of the islets in type-2 diabetes mellitus.
TL;DR: The results of spectroscopic measurements suggested that the hydrophobic interaction is the predominant intermolecular force in Cu(OAc)(2)L(2)O complexes under physiological pH condition.
TL;DR: The results indicate that the four complexes bound to DNA with different binding affinity, in the order complex 4>complex 3>complex 2>complex 1, and the complex 3 binds to DNA in both coordination and intercalative mode.
TL;DR: Capillary zone electrophoresis-inductively-coupled plasma mass spectrometry for studying the hydrolytic stability and the binding of the ruthenium anticancer drug candidates KP418, KP1019, and RAPTA-C to dGMP shows results that indicate KP418 was the most stable compound in both these respects.
TL;DR: Thermodynamic parameters obtained are suggestive of the involvement of different modes of interaction during binding for each complex although both were found to be intercalating in nature.
TL;DR: The main purpose of this work was to determine how the temperature dependence of both complex-formation and protonation constants can affect the pFe values on going from 25 degrees C to the physiological temperature of 37 degrees C at which chelating agents are active in vivo.