Showing papers in "Journal of Inorganic Biochemistry in 2010"

TL;DR: Experimental evidence indicated vanadium compounds exhibited multiple actions on mitochondria, which did induce oxidative stress on mitochondrial and thus caused PTP opening, which led to collapse of Deltapsi(m) and Cyt c release as the initiation of cell apoptosis.

TL;DR: Data confirm the key role of ruthenium itself in anti-metastatic activity and the activity of osmium arene complexes in other tumour models and the possibility of changing the non-arene ligands to tune the anticancer activity of Osmium in vivo.

TL;DR: This review summarizes recent research on the Isd system with a focus on the structural biology of heme recognition and concludes that Staphylococcus aureus employs the iron-responsive surface determinant (Isd) system as its primary heme-iron uptake pathway.

TL;DR: The new tetra-non-peripheral and peripheral 2-mercaptopyridine substituted gallium( III) and indium(III) phthalocyanine complexes and their quaternized derivatives and theirquinized derivatives have been synthesized and characterized.

TL;DR: Variable-temperature magnetic susceptibility studies indicate the existence of weak antiferromagnetic coupling between the copper(II) ions in complex 1, which was able to promote single and double strand DNA cleavage in both aerobic and anaerobic conditions and support the hydrolytic cleavage of DNA by the complex.

TL;DR: A new caged glutamate, based in a ruthenium bipyridyl core, that undergoes heterolytic cleavage after irradiation with visible light with wavelengths up to 532nm, yielding free glutamate in less than 50ns is introduced.

TL;DR: The 1.77-A resolution X-ray crystal structure of a dodecamer DNA duplex with the sequence 5'-CCTCTGGTCTCC-3' that has been modified to contain a single engineered 1,2-cis-{Pt(NH(3))(2)}(2+)-d(GpG) cross-link, the major DNA adduct of cisplatin is reported.

TL;DR: The roles ofalpha-syn and its interaction with Fe(III) and/or Fe(II) are discussed in the context of oxidative stress, metal-catalyzed alpha-syn aggregation, and iron transfer processes.

TL;DR: Five metal complexes of the third-generation quinolone antimicrobial agent sparfloxacin with Fe(3+), VO(2+), Mn(2 +), Ni(2+) and UO(2)(2+) have been prepared and characterized with physicochemical and spectroscopic techniques and a model for the structure of each complex is proposed.

TL;DR: This review summarizes the current knowledge of siderophore-mediated iron acquisition systems in the genus Staphylococcus and describes the mechanisms through which these systems are accomplished.

TL;DR: Cadmium(II) complexes have shown the most significant activities and have been characterized by spectroscopic studies: infrared, (1)H NMR, and electronic spectra.

TL;DR: These complexes exhibited biological activity on extra and intracellular forms of Trypanosoma cruzi in a time- and concentration-dependent manner with IC(50) values ranging from 7.8 to 18.7 μM, while the ligand H(2)L(2a) presented a trypanocidal activity on trypomastigote form better than the standard drug benznidazole.

TL;DR: Experimental results indicate that the [(Adpa)Mn(Cl)(H(2)O)] could be a new potential antitumor complex to target the mitochondria.

TL;DR: The Ag(I) complex submitted to in vitro antimycobacterial tests, using the Microplate Alamar Blue (MABA) method, showed a good activity against Mycobacterium tuberculosis, responsible for tuberculosis, with a minimal inhibitory concentration (MIC) value of 11.6microM.

TL;DR: This work aimed to determine if isoflavones, daidzein (4',7-dihydroxyisoflavone) and genistein and biochanin A could chelate with metals as is oflavone chelates with a 1:2 M/L stoichiometry.

TL;DR: The main experimental spectral features of these complexes reported in DNA or synthetic polynucleotides are better reproduced by the theoretical absorption spectra of the Delta enantiomers regardless of intercalation mode (major or minor groove).

TL;DR: These new structures of MnP with and without bound Mn(II) reveal an ordering/disordering of the C-terminal loop, which is likely required for Mn binding and release, and reveal the exact H atoms in several parts of the structure that are relevant to the catalytic mechanism.

TL;DR: This work provides strong crystallographic support for the previously proposed model that substrates bind and are reduced at a single 4Fe-4S face of the FeMo-cofactor and that when alpha-70(Val) is substituted by alpha- 70(Ile) access of substrates to Fe6 of this face is effectively blocked.

TL;DR: The data suggest that this cytotoxic effect of Fc-OH-TAM is expressed via a mechanism of action distinct from the non-genomic pathway observed with high doses of OH-Tamoxifen.

TL;DR: The demonstration by EPR that the Dp44mT-iron complex is redox-active confirms the previous studies using cyclic voltammetry, ascorbate oxidation, benzoate hydroxylation and a plasmid DNA strand-break assay and discusses the relevance of the redox activity to the biological effects of Dp 44mT.

TL;DR: The results of in vitro tests indicate that alendronate-containing cements significantly affect osteoclast proliferation and differentiation, whereas they promote osteoblast differentiation, to an extent which depends on cement composition.

TL;DR: The mononuclear nickel(II) complexes with the first-generation quinolone antibacterial agent oxolinic acid in the presence or absence of nitrogen-donor heterocyclic ligands (2,2'-bipyridine, 1,10-phenanthroline or pyridine) have been synthesized and characterized.

TL;DR: Use of these complexes can increase the mechanistic understanding of the effects of vanadium in vivo, as they appear to be as potent an inhibitor of alkaline phosphatase as sodium orthovanadate when comparing the K(cat)/K(m) term.

TL;DR: All the iron(III) complexes displayed chemical nuclease activity in the presence of 3-mercaptopropionic acid as a reducing agent and cleaved supercoiled pUC19 DNA to its nicked circular form via a mechanistic pathway that involves the formation of reactive hydroxyl radical species.

TL;DR: The complexes 1, 2, 4 and 5 have been revealed to catalyze effectively the dismutation of superoxide (O(2)(.-)) in xanthine-xanthine oxidase-nitro blue tetrazolium assay and IC(50) values were found to be 0.29, 0.39, 1.12 and 0.76 microM respectively.

TL;DR: The in vitro antimalarial data for gold(I) TSC complexes suggests that coordination of gold( I) to TSCs enhanced their efficacy against the malaria parasite Plasmodium falciparum and their inhibition of the parasite cysteine protease falCipain-2.

TL;DR: Cell cycle distribution and apoptosis study showed that Cd(II) complex and cisplatin might have some similarity in anticancer activity, which was not the case for cis platin and other studied complexes.

TL;DR: The synthesis, characterization and applications of a ruthenium-bipyridine based caged nicotine are reported, finding that this compound is active in biological systems, being able to elicit action potentials in leech neurons.

TL;DR: The Zn(II) complexes exhibit promising in vitro tumor-inhibiting activities, which are higher than that of cisplatin, against the following human tumor cell lines: promyelocyticfina leukaemia, hepatocellular carcinoma, gastric carcinoma and nasopharyngeal carcinoma.

TL;DR: Results demonstrated that the coordination of risedronate to different metal ions improved the antiproliferative effect against T. cruzi, exhibiting growth inhibition values against the intracellular amastigotes ranging the low micromolar levels.