Showing papers in "Journal of Investigative Dermatology in 1981"

TL;DR: An integrated review of the transfer of optical radiation into human skin is presented, aimed at developing useful models for photomedicine.

TL;DR: The results indicate that fibronectin is a major component present during wound healing, and appears to be type I collagen in the reticular dermis adjacent to the wound area.

TL;DR: Using a monochromator the action spectrum for ultraviolet phototherapy of psoriasis was determined for radiation between 254 and 313 nm and compared to theaction spectrum for erythema of uninvolved adjacent skin, suggesting that monochromaatic radiation may have advantages over broadband sources.

TL;DR: The finding that LC surface markers and to a lesser extent the cells themselves are particularly susceptible to UV irradiation has important implications in view of previous findings that LC are potent stimulators of antigen-specific and allogeneic T cell activation.

TL;DR: The unique mechanism for the cutaneous synthesis, storage, and steady release of vitamin D3 into the circulation prompted an investigation into the potential therapeutic benefits of using the skin as the site for the synthesis and absorption of vitamin-D3 metabolites.

TL;DR: The axillary microflora of 229 subjects was characterized quantitatively and the results correlated with whether the odor was pungent body odor or instead a faint "acid odor", found to be a stable mixture of Micrococcaceae, aerobic diphtheroids and Propionibacteria.

TL;DR: Differences in the thickness and the number of cell layers in the stratum corneum are insufficient to account for differences in percutaneous transport across leg and abdomen, and total lipid concentration may be the critical factor governing skin permeability.

TL;DR: Four patients with epidermolysis bullosa acquisita were investigated and indirect immunoelectron microscopic findings suggest that epidermal basal cells of affected patients may secrete the dermal substances to which the antibodies bind.

TL;DR: Primary cultures of fibroblasts obtained from the papillary, reticular and subcutaneous layer of scleroderma skin were analyzed for protein synthesis by metabolic labeling and radioimmunoassays and showed increases in the production of total protein and collagen as well as of fibronectin and type III procollagen as compared to cells from unaffected individuals.

TL;DR: A method which recognizes subtle differences in the localization of antigenic structures relative to the cleavage plane is described, which is more rapid and simpler to perform than electron microscopy.

TL;DR: The dye laser at 577 nm can selectively damage the cutaneous vascular plexus and may provide a basis for treatment of cutaneousascular lesions.

TL;DR: Repeated exposure to this UV-A delivering system yields long lasting dark brown skin pigmentation without any clinical or histological signs of "sunburn" (UV-B) damage, epidermal hyperplasia or thickening of the stratum corneum.

TL;DR: A child with neonatal lupus was evaluated and found to possess serum anti Ro(SSA) antibodies, while the infant's mother was asymptomatic but possessed anti Ro-SSA and anti La(SSB) antibodies.

TL;DR: Photoradiation therapy using hematoporphyrin derivative (Hpd) as the photosensitizing agent is being developed for local treatment of a wide variety of malignant lesions including those involving the skin.

TL;DR: Results suggest that in the re-epithelization of superficial wounds laminin and type IV collagen are not present in the initial epidermal-dermal interaction of the migrating epithelium but that BP antigen may be important in this early interaction.

TL;DR: The present review attempts to summarize the rapidly expanding literature on fibronectin, particularly in relation to wound healing and tissue repair.

TL;DR: Six butchers were found to be infected with a papillomavirus, distinct from the known skin HPVs and from BPV-1, which could not be characterized by restriction enzyme analysis.

TL;DR: Topical application of capsaicin to human skin produced an initial burning erythematous reaction which diminished over 24 hr leaving the skin unresponsive to histamine-induced axon reflex vasodilatation without altering sensitivity to pain, touch and temperature.

TL;DR: A formula was derived to allow conversion of TewL at any skin temperature to a standard reference temperature, which permits more accurate comparison of TEWL within and between subjects.

TL;DR: The mechanisms by which chlorpromazine photosensitizes damage to membranes, protein and DNA are described and compared to the mechanisms of photosensitization by psoralens, porphyrins, dyes, and other molecules.

TL;DR: The mechanism of the antifungal action of the imidazole antimycotics, miconazole ano clotrimazole, on Saccharomyces cerevisiae was explored and the fungistatic effect correlated with inhibition of ergosterol synthesis and elevated lanosterol/ergosterol ratios in the organisms.

TL;DR: Another gender of photomedicine therapy is discussed which includes in vivo photoactivation of medicines, photon-dependent drug delivery, and manipulation of host and exposure source to maximize therapeutic index.

TL;DR: The deaths of infants after the use of baby powder contaminated with 6.6% hexachlorophene highlighted the need for increased understanding of drug effects not only from the viewpoint of the skin as a target organ, but also of percutaneous penetration and resultant blood levels.

TL;DR: This review represents an effort to provide current research results in the aforementioned areas and an attempt to meld these events into a comprehensive overview of photocarcinogenesis.

TL;DR: It is concluded that the active agent causing flushing in coffee at 60 degrees C is heat, not caffeine.

TL;DR: The results suggest that pemphigus-induced acantholysis may be caused by at least 2 different types of enzyme.

TL;DR: Spontaneous healing and the fact that experimental infections were produced only under occlusion illustrates the importance of predisposing factors in tinea versicolor.

TL;DR: Good correlation between clinical efficacy and specific binding was observed for all 3 ligands, and there was an indication that the binding capacity of the receptor system is higher the younger the age of the skin donor.

TL;DR: Using the pulsed ultrasound technique, an early onset of dermal thinning could be detected 2 days following treatment with creams containing 0.05% clobetasol propionate and 0.1% beta-methasone 17-valerate.

TL;DR: Human and murine lymphoid cell populations were induced to express terminal deoxynucleotidyl transferase, a marker of early lymphoid differentiation, by exposure to allogeneic or syngeneic epidermal cells, suggesting that epider mal cells can induce lymphoids cell differentiation in vitro.