scispace - formally typeset
Search or ask a question

Showing papers in "Journal of Laboratory and Clinical Medicine in 1962"


Journal ArticleDOI
TL;DR: In this paper, the fluorescence enhancement of a phenylalanine-ninhydrin reaction product by a peptide, leucylalaninc, was used for the determination of PAL levels in adult, pediatric, and phenylketonuric patients.

483 citations



Journal ArticleDOI
TL;DR: By serial daily creatinine analyses over long experimental periods on a metabolic ward, "timing" artifact in 24 hour collections was minimized; this is an important source of error if single 24 hour or random samples are used.

171 citations




Journal ArticleDOI
TL;DR: The maintenance of the osmotic fragility of erythrocytes during incubation in serum is dependent on adequate energy production from glucose metabolism and the prevention of a decrease in the free cholesterol of serum.

156 citations






Journal ArticleDOI
TL;DR: The error for estimation of 8 human serum proteins over a very wide range is calculated and the coefficients of variations for the determinations of each of these proteins are shown to be constant.

Journal ArticleDOI
TL;DR: Endocrine effects on collagen synthesis have been studied by measuring the incorporation of proline into Hydroxyproline by rat cartilage in vitro, and cortisol added in vitro in a concentration of 0.9 μg per milliliter did inhibit formation of labeled hydroxy Proline.





Journal ArticleDOI
TL;DR: The direct measurement of plasma lipoprotein lipase activity in vitro failed to show a satisfactory rise following heparin among fibrocystic patients as compared with normal control subjects, which may represent a secondary effect of poor intestinal absorption of triglycerides because of a deficiency of pancreatic lipase in the duodenal secretions.

Journal ArticleDOI
TL;DR: A micromethod for the determination of whole blood ammonia is described based on the cation exchange principle in which sodium and potassium ions are exchanged instantaneously for ammonium.





Journal ArticleDOI
TL;DR: A modification of the van de Kamer and associates' method for fecal fatty acids, which is effective in the recovery of hydroxy acids, is proposed, and is proposed to demonstrate the reliability of the procedures.



Journal ArticleDOI
TL;DR: The feasibility of in vivo dissociation of the rheumatoid factor has been established and lends encouragement to the possibility that this substance may be reduced in the serum with more potent sulfhydryl compounds.

Journal ArticleDOI
TL;DR: 6-MP differs from such agents as total body irradiation and cortisone in suppressing at least the primary and secondary responses and perhaps interfering with immunologic memory as well.

Journal ArticleDOI
TL;DR: In vitro experiments with liver slices and homogenates and administration of the isotopically labeled compound in vivo to rats and man gave no evidence of any significant capacity for catabolism of this substance.


Journal ArticleDOI
TL;DR: Divalent ion clearances during mercurial diuresis were much greater, as related to Na or Cl excretion, than those observed during osmotic diureis, suggesting specific mercurials depression of divalent ion transport.