Showing papers in "Journal of Neuroimmunology in 2022"

TL;DR: In this paper , a systematic review was performed by screening published articles and preprints of cases of CNS demyelination in association with COVID-19 vaccines in PubMed, SCOPUS, EMBASE, Google Scholar, Ovid and medRxiv databases, until September 30, 2021.

TL;DR: In this article, a systematic review was performed by screening published articles and preprints of cases of CNS demyelination in association with COVID-19 vaccines in PubMed, SCOPUS, EMBASE, Google Scholar, Ovid and medRxiv databases until September 30, 2021.

TL;DR: In this article , Dantzer et al. used stellate ganglion block to block the sympathetic chain activity of patients with COVID-19 and showed that this block can improve the autonomic nervous system response to pro-inflammatory cytokines.

TL;DR: In this paper , the authors provide preclinical and clinical evidence of DAMPs and the BBB permeability as contributors to depression and neuroinflammation, and discuss pharmacologic approaches that could potentially modulate DAMPs, altered cytokines transport systems, and engaging toll-like receptors (TLRs) by pathogen-associated molecular patterns (PAMPs) or damageassociated molecular pattern (DAMPs).

TL;DR: In this paper , the role of rituximab in relapse prevention among patients with myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG)-associated disorders was investigated.

TL;DR: In this paper , a 15-year-old female presented with fever, altered consciousness, and convulsions after taking the second shot of the vaccine and showed the presence of thrombocytopenia and myocarditis.

TL;DR: In this paper , the authors provide updates on SPSD and its expanding clinical spectrum, prognostic markers, and treatment considerations, and highlight gaps in our knowledge appropriate for future research directions.

TL;DR: In the absence of a reliable biomarker to confirm neurosarcoidosis, the diagnosis is based on identifying a compatible clinical and imaging profile and identifying pathological evidence of non-caseating granulomas by biopsy of other organs or, if needed, in the nervous system, with the exclusion of other causes of granulomatous disease and possible neuroinfectious and neuroinflammatory disorder mimics as mentioned in this paper .

TL;DR: In this article , the authors showed that a transient increase in the microglial population is beneficial during endotoxin-induced inflammation in the mouse brain because it attenuates sickness responses.

TL;DR: In this article , the authors describe 9 patients diagnosed with myelin oligodendrocyte glycoprotein (MOG)-IgG associated disorder following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

TL;DR: In this article , the authors report clinical outcome, development of humoral and T-cell mediated immunity in convalescent COVID-19 people with multiple sclerosis (pwMS) treated with ofatumumab in the ALITHIOS study from a single center.

TL;DR: In this article , the authors report two rare neurological manifestations post-COVID-19 infection; multiple sclerosis (MS) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), and review other CNS inflammatory demyelinating diseases associated with SARS-CoV-2, including optic neuritis (ON) and neuromyelitis optica spectrum disorders (NMOSD).

TL;DR: In this article , small fiber neuropathy (SFNFN) is reported in over 40% of systemic cases of granulomatous neuropathy, which typically responds to corticosteroids and intravenous immune globulin or infliximab.

TL;DR: In this paper , a clinical experience with service-line LRP4-IgG cell-based testing in electrodiagnostically confirmed myasthenia gravis (MG) patients and controls was reported.

TL;DR: In this paper , the effects of Ginkgolide K (GK) on MPTP exposure in mice were reported, in which GK ameliorated the gait dysfunction and dopaminergic neuron loss.

TL;DR: In this article , the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE), an animal model of MS, was tested to substantiate the relationship between ferroptosis and oligodendrocyte (OL) loss and demyelination.

TL;DR: In a subset of SNMG patients, acetylcholine receptor (AChR) autoantibodies are detectable by a clustered AChR cell-based assay (CBA) and these findings corroborate the clinical need for clustered A ChR CBA testing when evaluating SN MG patients.

TL;DR: In this paper , a receiver operating characteristic (ROC) curve was employed to explore the predictive value of IL-32 levels in neuro-Behcet disease (NBD) patients.

TL;DR: In this paper , a subset of seronegative myasthenia gravis (MG) patients are detected by a clustered AChR cell-based assay (CBA) and autoantibody positivity was further validated in 17/18 patients.

TL;DR: In this paper, the role of high mobility group box 1 (HMGB1) in brain barrier (BBB) dysfunction induced by hyperglycemia was reviewed and a promising therapeutic target for countering diabetes-associated cognitive decline was proposed.

TL;DR: In this paper , the role of high mobility group box 1 (HMGB1) in brain barrier (BBB) dysfunction induced by hyperglycemia was reviewed and a promising therapeutic target for countering diabetes-associated cognitive decline was proposed.

TL;DR: The relationship of plasma levels of complement markers C3 and C4, with schizophrenia, sociodemographic and clinico-psychological factors were studied in 183 patients and 212 controls as mentioned in this paper .

TL;DR: In this paper , the authors evaluated longitudinal interleukin (IL)-6 levels in sera of NMOSD patients in correlation with disease activity and brain volume and found that increased IL-6 levels correlated with relapse severity and brain atrophy.

TL;DR: In this article , the authors discuss the clinical, laboratory and radiological findings that aid the clinician in distinguishing between the two conditions, and discuss the literature on the potential for sarcoidosis and MS to coexist in some patients, and how to approach the treatment of these overlap patients.

TL;DR: In this paper , the authors measured inflammation and platelet and neutrophil activation markers in patients with cerebral small vessel disease (cSVD) and age-matched controls to identify potential novel biomarkers for cSVD, gaining new insights into its pathophysiology.

TL;DR: In this article , the authors performed electroencephalographic and electromyographic recordings on MyD88-KO mice and wild-type mice to investigate their sleep/wake cycles and found that deletion of myD88 induces insomnia and depressive behavior, at least in part, by affecting microglial homeostasis functions.

TL;DR: In this paper , the neutrophil-to-lymphocyte ratio (NLR) was found to predict poor outcomes in adult anti-NMDAR encephalitis (NMDARE).

TL;DR: In this article , the authors reviewed the evidence supporting the link of EBV with MS and the mechanisms by which EBV might trigger MS and cause continued disease activity, and also discussed the trials of agents to reduce or eliminate EBV in humans.

TL;DR: In this article , an end 20-year-old female patient with symptoms of OCD was diagnosed with sarcoidosis, and an advanced diagnostic work-up revealed inflammatory cerebrospinal fluid (CSF) changes (elevated IgG index, CSF-specific oligoclonal bands, intrathecal IgG synthesis, and a positive MRZ reaction).

TL;DR: The authors showed that repeated administration of methionine at a dose equivalent to two-fold of daily dietary intake for seven days enhanced activation of microglia and inflammation in the brain, and decreased neurogenesis in the hippocampus without affecting degeneration.