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Showing papers in "Journal of Neuroscience Methods in 2004"


Journal ArticleDOI
TL;DR: EELAB as mentioned in this paper is a toolbox and graphic user interface for processing collections of single-trial and/or averaged EEG data of any number of channels, including EEG data, channel and event information importing, data visualization (scrolling, scalp map and dipole model plotting, plus multi-trial ERP-image plots), preprocessing (including artifact rejection, filtering, epoch selection, and averaging), Independent Component Analysis (ICA) and time/frequency decomposition including channel and component cross-coherence supported by bootstrap statistical methods based on data resampling.

17,362 citations


Journal ArticleDOI
TL;DR: This study identifies optimal electrode sites for muscles in the lower extremity by providing a standard landmarking technique for the localization of the IZ of each muscle so that surface EMG electrodes can be properly positioned between the I Z and a tendon.

539 citations


Journal ArticleDOI
TL;DR: This report compares the three classical spectral analysis approaches: Fourier, Hilbert and wavelet transform and demonstrates that the three techniques are in fact formally (i.e. mathematically) equivalent when using the class of wavelets that is typically applied in spectral analyses.

430 citations


Journal ArticleDOI
TL;DR: It is found that positive-then-negative biphasic voltage-controlled pulses are more effective than any of the other pulse shapes tested, when compared at the same peak voltage, suggesting that voltage-control, with its inherent control over limiting electrochemistry, may be advantageous in a wide variety of stimulation scenarios.

316 citations


Journal ArticleDOI
TL;DR: It is shown that constitutive reductions in SERT are associated with increases in 5-HT in the extracellular signaling space in the absence of changes in dopamine neurochemistry, and use of zero net flux microdialysis appears warranted in investigations of serotonergic synaptic function.

275 citations


Journal ArticleDOI
TL;DR: It is suggested that an inexpensive desktop printer may be an accessible tool for making micro-island cultures and other basic patterns, and ink-jet printing may be extended to a range of developmental neuroscience studies, given its ability to more easily layer materials, build substrate-bound gradients, construct out-of-plane structure, and deposit sources of diffusible factors.

233 citations


Journal ArticleDOI
TL;DR: In vitro electrochemical potential transient measurements in buffered physiologic saline indicate that polarizing the AIROF beyond the potential window for electrolysis of water results in the observed degradation.

196 citations


Journal ArticleDOI
TL;DR: An automatic system for the detection and classification of MU action potentials from multi-channel surface EMG signals that was validated on simulated signals, at different levels of force, generated by a structure based surface EMg model and able to identify a MU sample representative of the muscle.

178 citations


Journal ArticleDOI
TL;DR: Methods for the selection, development and assessment of animal models of PD, the role of non-human primates and the concept of "multiple models/multiple endpoints" to predict the success in the clinic of neuroprotective strategies are discussed.

169 citations


Journal ArticleDOI
TL;DR: A rapid liquid chromatography/tandem mass spectrometry method has been developed for the measurement of dopamine, 5-hydroxytryptamine (5HT) and norepinephrine (NE) in brain microdialysates and the neurotransmitters and cocaine were resolved in a single 4-min run using a binary gradient elution profile.

168 citations


Journal ArticleDOI
TL;DR: Triphenyltetrazolium chloride and cresyl violet staining showed a high degree of correlation in infarct area and volume indicating that both methods are suitable for producing accurate measurements of cerebral experimental infarCTs.

Journal ArticleDOI
TL;DR: The results suggest that the automatic recognition algorithm is applicable for distinguishing between alert, drowsy and sleep state in recordings that have not been used for the training.

Journal ArticleDOI
TL;DR: It is illustrated that a 50% decrease in BDNF does not appear to be sufficient to cause measurable changes in basal extracellular 5-HT concentrations and, furthermore, that constitutive reductions in SERT expression are not associated with altered BDNF protein levels at the ages and in the brain regions examined in this study.

Journal ArticleDOI
TL;DR: A new method for spike sorting is proposed which partly solves the overlapping problem and the over-fitting problem can be partly avoided.

Journal ArticleDOI
TL;DR: A series of naphthylstyryl-pyridinium dyes being synthesized having the same chromophore as di-8-ANEPPS and the quaternary ammonium headgroup of RH795 yielded the best combination of signal-to-noise ratio, moderate phototoxicity and absence of dye internalization.

Journal ArticleDOI
TL;DR: The design, testing, and evaluation of a 16 channel wearable telemetry system to facilitate multichannel single unit recordings from freely moving test subjects and was successfully used to record signals from awake, chronically implanted macaque and owl monkeys.

Journal ArticleDOI
TL;DR: The data demonstrate the advantage of Pt/Ir over stainless-steel electrodes when used in short-term HFS and indicate that HFS using Pt/iridium-electrodes pulsed with 3 microC/cm2/phase over 3 days did not produce any relevant tissue damage in the STN.

Journal ArticleDOI
TL;DR: Evaluated the efficacy of four putative pan-neuronal markers for the enteric nervous system (ENS) and found Cuprolinic Blue and HuC/D provide a complementary set of labels to study the total neuronal population of the ENS.

Journal ArticleDOI
TL;DR: It is concluded that the PSTH-based method is an efficient alternative to more sophisticated methods such as LDA and ANNs to study how ensemble of neurons code for discrete sensory stimuli, especially when datasets with many variables are used and when the time resolution of the neural code is one of the factors of interest.

Journal ArticleDOI
TL;DR: Compared to the responses to footshock alone, when the footshock was paired with an unfamiliar tone, there was no change in the response to the first stimulus presentation, but a significant augmentation of responses during subsequent presentations, giving weight to the view that dopamine is not involved in the learning per se, but rather in the processing of learned information.

Journal ArticleDOI
TL;DR: An overview of what optical imaging has contributed to the authors' knowledge of the functional architecture of sensory cortices, their development and plasticity and the utility of OI for functional studies of the human brain as well as in animal models of neuropathology is discussed.

Journal ArticleDOI
TL;DR: Real-time PCR analysis results indicate that mRNA expression can be detected in all brain specimens for beta-actin, 18S rRNA, GAPDH, and also synaptophysin, a known marker for AD, and suggest that synaptophysical activity is down-regulated in AD brain specimens compared to control brain specimens.

Journal ArticleDOI
TL;DR: It is found that microwave irradiation generally provided the highest and most consistent levels of protein phosphorylation, regardless of the substrates examined in striatum and hippocampus, while flash-freezing resulted in the least preservation of phospho-state.

Journal ArticleDOI
TL;DR: Transgenic YFP-H mice prove to be a valuable tool to study mechanisms of Wallerian degeneration in vivo and in vitro and can be traced in peripheral nerves for unusually long distances exploiting confocal fluorescence imaging.

Journal ArticleDOI
TL;DR: This work seeks to establish the feasibility of characterizing the ultrastructure of brain tissue disruption associated with the implantation of carbon fiber voltammetric microelectrodes in rats anesthetized with chloral hydrate.

Journal ArticleDOI
TL;DR: It is suggested that a facet joint tensile strain threshold may exist above which pain symptoms result and continued investigation into the relationship between injury mechanics and nociceptive physiology will strengthen insight into painful facet injury mechanisms.

Journal ArticleDOI
TL;DR: A combination of methods for retrieving locations and velocities and recognizing arrests from time series of coordinates of an animal's center of gravity are suggested using robust nonparametric methods, such as Running Median (RM) and locally weighted regression methods.

Journal ArticleDOI
TL;DR: A computer image processing system for quantifying zebrafish behavior is developed and is a very useful tool for quantitatively scoring the schooling behavior of multiple fish.

Journal ArticleDOI
TL;DR: A dissociation between functional and histological outcome was found emphasizing the importance of combining both outcome measures for evaluation of neuroprotective strategies.

Journal ArticleDOI
TL;DR: A computer-based sleep scoring algorithm was devised for the real time scoring of sleep-wake state in Wistar rats and was as reliable as the agreement between three human scorers (88%).