Showing papers in "Journal of Pharmaceutical and Biomedical Analysis in 2015"

TL;DR: This review presents current knowledge on the effects on natural microbial communities of some pharmaceuticals and of some biocides commonly found as environmental microcontaminants.

TL;DR: The research strategies and analytical platforms commonly applied in the metabolomics studies are discussed and some limitations and further improvements which should be considered are discussed taking in mind potential applications of metabolomic research and practice.

TL;DR: Different stable isotope labelling methods which incorporate metabolic labelling in live cells, ICP-MS based detection and post-harvest chemical label tagging for protein quantification are described, in addition to summarising their pros and cons.

TL;DR: A general prospect of the principal analytical techniques which can be employed for a suitable characterization of drug-cyclodextrin systems in the solid state, evidencing their respective potential advantages and limits is presented.

TL;DR: In the present review, the instrumentation and experimental conditions to perform "advanced SFC" are discussed and the applicability of SFC in pharmaceutical analysis, including the determination of drugs in formulations and biofluids is critically discussed.

TL;DR: An overview of theoretical and practical aspects of modern IEX applied for the characterization of therapeutic proteins including monoclonal antibodies (Mabs) and antibody drug conjugates (ADCs).

TL;DR: The authors scoured through the most recent, high-impact papers archived in Pubmed, ScienceDirect, Wiley and Springer databases to compile this review to pique the interest of researchers towards cancer metabolomics.

TL;DR: It is proved that the mobile phase temperature was not relevant for tuning selectivity, while optimal salt gradient program can be easily found based on only two initial gradients of different slopes, and salt gradient CEX can be considered as a generic multi-product approach.

TL;DR: Altered levels of metabolites detected in serum between Alzheimer's disease patients and healthy controls confirmed the involvement of multiple affected pathways, such as energy deficiencies, oxidative stress, hyperammonemia, and others.

TL;DR: The total mass concentration of fluoroquinolones in raw wastewater was in the range that inhibited E. coli growth, suggesting that concerns over antibiotic presence in wastewater and wastewater-impacted surface water are valid and the removal efficiency for fluoroquolones was found to be negatively correlated to biochemical oxygen demand removal and positively correlated to phosphorus removal.

TL;DR: The HPLC method was used to control 35 teeth bleaching products during a market survey and highlight for 5 products, hydrogen peroxide contents higher than the regulated limit, to assess the analytical method proposed.

TL;DR: An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic groups was developed based on off-line solid-phase extraction and ultra-high performance liquid chromatography coupled to tandem mass spectrometry.

TL;DR: The power of (1)H NMR spectroscopy as a first-line method for the detection of adulterated herbal/natural DS and the need for more effective quality control of purported herbal DS are demonstrated.

TL;DR: In this paper, a metabolomics study related to urinary metabolic fingerprinting analyses has been performed in order to scrutinize potential biomarkers that could help in explaining the pathomechanism of the disease and be potentially useful in its diagnosis and prognosis.

TL;DR: Different separation modes and detectors that have been employed in ME to analyze various classes of biomedical analytes (e.g. pharmaceuticals and related substances, nucleic acids, amino acids, peptides, proteins, antibodies and antigens, carbohydrates, cells, cell components and lysates) are described.

TL;DR: In predicting ginseng age using Back Propagation-Artificial Neural Networks (BP-ANN), E-nose data was found to predict more accurately than GC-MS data, and 7 constituent of terpenes could be accurately explained and predicted by using gas sensors in PLS models.

TL;DR: The different methods applied for feces processing prior to metabolite analysis are summarized and illustrated using selected examples to highlight the effect of sample preparation on the metabolic profile obtained.

TL;DR: The developed method was successfully applied to the identification and quantitation of anti-TB drugs in patients with multi-drug resistant TB.

TL;DR: A rapid and simple LC-MS/MS method was developed and validated for the simultaneous estimation of sofosbuvir (SF) and its metabolite GS-331007 (GS) using famotidine as an internal standard (IS) and successfully applied to a bioequivalence study in human volunteers.

TL;DR: The contents of malonyl ginsenosides, amino acids, and polysaccharides, based on decreasing order, ranked as follows: fresh ginseng>frozen gINSeng>white ginseneng>stoved ginsEng>red gins Eng>black ginsENG.

TL;DR: This article overviewed recent reports employing application of untargeted and targeted metabolomic analyses in particular CVDs and focused on applications of various analytical platforms and metabolomics approaches which may contribute to the explanation of the pathomechanisms of different cardiovascular diseases.

TL;DR: In this article, the authors investigated regional metabolic alterations in brain from the APP/PS1 mice, a transgenic model that reproduces well some of the neuropathological and cognitive deficits observed in human Alzheimer's disease.

TL;DR: This review summarizes the recent advances in the chemical analysis of the flavonoids in G. biloba and its finished products (from 2009 to 2014), including chemical composition, sample preparation, separation, detection and different quality criteria.

TL;DR: Sensitive in vitro bioassays could reduce the current detection problems by measuring the estrogenic activity of environmental samples and screen and assess the risks of endocrine active pharmaceuticals with a focus on estrogenic pharmaceuticals in environmental waters is discussed.

TL;DR: An ultra-high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) method was developed to monitor multiple components for the quality control and global evaluation of ginseng products during processing.

TL;DR: Estimation of antioxidant activity in leaves and seed extracts by DPPH and ABTS in-vitro assays and antioxidant capacity in C2C12 cell line showed that papaya extracts exhibit high antioxidant activity.

TL;DR: Piperine significantly improved the in vivo bioavailability of emodin and the influence of piperine on the pharmacokinetics of Emodin may be attributed to the inhibition of glucuronidation of emmodin.

TL;DR: Compared with other reviews focused on EME, the authors have especially highlighted their personal views about the most promising directions for the future, and identified the areas where more fundamental work is required.

TL;DR: It is suggested that ferrate(VI) can effectively remove SMX, DCF and CBZ from the test solutions, with greater than 80% removal under optimum conditions, however, the removal efficiency of BZF was very low, less than 25% under the studied conditions.

TL;DR: It is shown that chemometric analysis of ATR-FTIR fingerprints is a valuable tool to discriminate genuine from counterfeit samples and to classify counterfeit medicines.