Showing papers in "Journal of Pharmaceutical Sciences in 1964"

TL;DR: The use of per cent absorbed versus time plots to elucidate kinetic models for drug absorption is described and the following kinetic models are considered: absorption by a zero- order process, by two zeroorder processes operating in parallel, by a first-order process, and by two parallel firstorder processes.

TL;DR: Among the carbohydrates used in compressed tablets, mannitol is the only one which possesses high heat stability, but this substance melts at 167°, but does not decompose at temperatures up to 250°.

TL;DR: The synthesis of a series of 5-pyridyl analogus of the psychopharmacologically active class of compounds, 1,4-benzodiazepines, is described and these compounds are being screened for psychosedative, muscle relaxant, and anticonvulsant activity.

TL;DR: A high degree of microbiological activity was demonstrated when aqueous glutaraldehyde solutions were alkalinized with the appropriate buffer, and no damage to lensed instruments was observed with 2 per cent solutions.

TL;DR: Freeze-dried juice obtained from Aloe vera and heated for 15 minutes at 80° inhibited several test microorganisms.

TL;DR: Radioassay of blood, various tissues, and excreta indicated that the drug was well absorbed and the fate of oxazepam in humans was similar to that in dogs and pigs.

TL;DR: A quantitative evaluation of the effect of temperature on the interaction of methyl, propyl, and butylparaben, phenol and p-chlorophenol with polysorbate 80 was obtained with an equilibrium dialysis technique utilizing a plexiglas dialysis cell and a semipermeable membrane.

TL;DR: Possible interaction of chlorobutanol and two aromatic alcohols, benzyl and phenylethyl, with polysorbate 80, polyvinylpyrrolidone, and methylcellulose was investigated by equilibrium dialysis studies.

TL;DR: Inter- and intrasubject variations in drug absorption kinetics were studied in 15 subjects who ingested 975 mg.

TL;DR: The solubility of salicylic acid was determined in various pure solvents and binary solvent mixtures having known or measured dielectric constants and a family of curves was observed having a common shape and a common peak dielectrics requirement.

TL;DR: Profiles of the apparent solubility of triamterene (2,4,7-triamino-6-phenylpteridine) as a function of pH were obtained in the presence of hydrochloric, nitric, sulfuric, phosphoric, and acetic acids, and the utility of the phase solubilities technique in detecting and studying complex salts is discussed.

TL;DR: Investigation of encapsulation requirements for pharmaceutical oils showed that saponification values had little effect on encapsulation and that acid values and surfactants decreased the degree of encapsulations.

TL;DR: A method based on dissolution rate measurement was developed to obtain solubility data for rapidly reverting solid states and Experimental tests of the method showed it to be valid.

TL;DR: The unsupported vinyl films possessed superior mechanical properties of those tested and there was no discernible decomposition according to infrared analysis of the films, due to thermal, photo-oxidation, and/or aging effects.

TL;DR: Reactivity toward acetic anhydride, partition studies, and infrared spectra of light degraded solutions of CLP HCI suggest ring hydroxylation occurs during irradiation, and phenolic and other unidentified compounds formed on irradiation apparently result from degradation of the photolabile CLP-O.

TL;DR: With the use of thin-layer chromatography and comparative chromatograms with synthetic acetylated phenylephrine derivatives, three acetylation of the secondary amine function could be identified in tablet formulations.

TL;DR: A technique for qualitative identification and quantitative determination of micro quantities of ergot alkaloid has been developed and has been extended to the resolution and quantitative estimation of the alkaloids.

TL;DR: Hildebrand′s equation appears most applicable to solvents whose solubility parameters are quite similar to those of the solutes; it is strictly applicable to nonpolar rather than polar systems.

TL;DR: Moisture content, granule screen analysis, and compressibility tests were used to evaluate the granulated product and illustrated the ability of the process to maintain product uniformity from run to run.

TL;DR: The rather abrupt change in permeability observed in the temperature range of 30–35° indicates that caution must be exercised in interpreting accelerated aging data at higher temperatures with these films.

TL;DR: It is shown that the absorption rate of drugs can be modified by formation of complexes which differ from the free drug mainly in size or in lipoid-water partition coefficient.

TL;DR: A method has been developed which will, it is hoped, be especially useful in pharmaceutical product development work as distinguished from academic research studies in which the goals are to determine reaction rates or orders or to elucidate reaction mechanisms.

TL;DR: An in vitro model to simulate some factors involved in the absorption process and results of the equilibrium studies are in general agreement with predictions of the pH-partition theory.

TL;DR: The solubility of carbon dioxide, krypton, and xenon has been measured at 1 Atm and at temperatures of 25, 30, 37, and 45° in distilled water and aqueous solution.

TL;DR: In this article, an instrument was developed to measure stress relaxation of a powder bed under constant strain, and preliminary relaxation data obtained on several powders indicated correlation with physical properties of the compacts.