Showing papers in "Journal of Pharmaceutical Sciences in 1996"

TL;DR: The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.

TL;DR: This Review primarily focuses on newer findings concerning cyclodextrin derivatives which are likely to receive regulatory acceptance due to improved aqueous solubility and safety profiles as compared to the unmodified cyclodexypropyl-beta-cyclodextrins.

TL;DR: The results suggest that the denaturation of proteins during freeze-thawing can be ascribed primarily to the increase in the area of the ice-water interface during freezing.

TL;DR: The results indicate that dynamic polar surface area is a promising alternative model for the prediction of oral drug absorption in two common in vitro models of the intestinal wall.

TL;DR: In this article, the performance of PEO-PBLA block copolymers with and without physically trapped IMC in the inner core of the micelles (IMC/PEO-pBLA) were studied by dynamic light scattering and gel permeation chromatography/HPLC as well as an in vitro release test of IMC from the mouselles.

TL;DR: It could be stated that the main factor responsible for the favorable comeal transport of indomethacin is the colloidal nature of these carriers rather than their inner structure or composition.

TL;DR: Systematic evaluation of plasma clearance kinetics and biodistribution of liposomes containing hydrogenated soy phosphatidylcholine, cholesterol, and 5 mol % the polymer-lipid conjugates in mice revealed the following.

TL;DR: A coculture system of absorptive Caco-2 cells and mucus-secreting HT29-MTX cells was developed and the permeability of a range of different drugs was tested, finding variable goblet cell frequency can be achieved, preserving a significant barrier to drug transport and maintaining the differentiated features of both cell types.

TL;DR: It is suggested that protein precipitation in supercritical fluids can be used to form particles suitable for controlled release, direct aerosol delivery to the lungs, and long-term storage at ambient conditions.

TL;DR: The strong dependence of HPMC release on viscosity grade is explained on the basis of the concept of polymer disentanglement concentration and swelling inhomogeneity is proposed as being responsible for a higher apparent drug diffusivity and release rate.

TL;DR: An examination of the literature indicates that discussions concerning solid-state reactivity in the amorphous state have followed along two lines; in some work correlations appear to exist between the rate of reactivity and the glass transition temperature, Tg, strongly supporting the role of water as a plasticizer in facilitating chemical reactivity by increasing molecular mobility.

TL;DR: This study developed acoustically reflective liposomes, which are suitable for antibody conjugation, without using gas or any other agent entrapment, and can be used for ultrasonic image enhancement and/or treatment of targeted pathologic sites.

TL;DR: The results show the existence of break points in the plot of delta T/k vs molality at 0.018, 0.013, and 0.007 m, respectively, in good agreement with previous published critical micelle concentration values.

TL;DR: Permeability results with peptides that varied systematically in chain length, lipophilicity, and amide bond number support a model in which the principal determinant of peptide transport is the energy required to desolvate the polar amides in the peptides for the peptide to enter and diffuse across the cell membrane.

TL;DR: In-vitro and in-vivo results showed that the P407 formulations of MT-I with MC or HPMC as an additive showed potential for use as a controlled-release delivery system forMT-I.

TL;DR: It is suggested that bilayer disordering agents, such as linoleic acid and ultrasound, transform the SC lipid bilayers into a fluid lipid bilayer phase or create a separate bulk oil phase for larger solutes, thereby producing greater enhancements for largersolutes.

TL;DR: The mechanism of paracellular expansion by absorption enhancers, e.g., EDTA, sodium caprate, and decanoylcarnitine, was studied, the focus being on the process of actin microfilament contraction in the tight junction.

TL;DR: It is found that quantitating the area of overlap between area-normalized spectra provides a reliable, objective method to compare overall spectral similarity, and is demonstrated with selected protein spectra.

TL;DR: From this limited data set, it appears that uptake characteristics for human colon and rectum are similar to those of Caco-2 cell monolayers, suggesting that flux measurements across CACO-2 monolayer may be predictive for permeabilities of human Colon and Rectum for different classes of therapeutics.

TL;DR: A dramatic decrease in both particle size and drug incorporation in the carrier as the rate of mixing increased, and a theoretical model for nanoparticle formation is proposed that considers the most significant variables, and an empirical relationship to predict mean particle size is presented.

TL;DR: A novel optical image analysis method was developed to examine the dynamic swelling behavior of hydroxypropyl methylcellulose-based matrix tablets in situ and reveals that as the matrix swells, the polymer concentration profiles, as well as the gel layer thicknesses, develop equally in both the axial and radial directions.

TL;DR: Several microemulsion formulations were demonstrated to be promising for oral delivery of insulin based on the results of stability tests and acid-protection efficiency.

TL;DR: The data indicate that lymphatic transport of the free base of Hf is a major contributor to oral bioavailability when formulated in appropriate lipid vehicles, and suggest that formulation as increasingly disperse systems facilitates transport in this animal model.

TL;DR: Data suggest that the improved absorption of Hf.HCl in the fed state is most likely due to the increased solubilization and dissolution of the drug in the presence of bile salt mixed micelles.

TL;DR: No evidence was generated that supported the existence of true polymorphs of carbamazepine dihydrate, but observations could be due to a trace amount of nonhydrated original polymorph existing in the diHydrate phase that acts as a seed to regenerate the original polymorph under conditions where liberated hydrate water cannot readily escape from around the sample during dehydration.

TL;DR: Results show that during a 16 h dissolution study drug is completely released following the zero-order kinetics with no burst effect, and the release rate remains around 0.1 mg min-1 throughout the dissolution study.

TL;DR: A combination of the conjugate and BFA can cause a net 45-fold increase in the apical-to-basolateral transport of insulin across Caco-2 cell monolayers, indicating that free amino groups of insulin were regenerated either during or after the transcytotic process.

TL;DR: The partition coefficient of paclitaxel partitioning into small unilamellar lipid vesicles composed of 1-palmitoyl-2-oleoyl -sn-glycero-3-phosphocholine is determined using two different methods, namely high-sensitivity titration calorimetry and fluorescence spectrometry.

TL;DR: The strategy was focused on the prevention of antigen exposure to environmental conditions, and a microencapsulation process was designed and optimized to provide an inert and insulated environment for the bioactive material inside controlled-release systems.

TL;DR: The need to blend PEO with highly compactible excipients in order to produce tables on a high-speed production press is suggested.