Journal•ISSN: 1056-8719
Journal of Pharmacological and Toxicological Methods
Elsevier BV
About: Journal of Pharmacological and Toxicological Methods is an academic journal published by Elsevier BV. The journal publishes majorly in the area(s): QT interval & hERG. It has an ISSN identifier of 1056-8719. Over the lifetime, 2439 publications have been published receiving 52661 citations.
Topics: QT interval, hERG, Safety pharmacology, Medicine, Contractility
Papers published on a yearly basis
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TL;DR: There are currently about 10000 drug-like compounds, and true diversity does not exist in experimental combinatorial chemistry screening libraries because current ADME experimental screens are multi-mechanisms, and predictions get worse as more data accumulates.
3,041 citations
TL;DR: Some of the innate characteristics of the HEK cell are highlighted in order that its suitability as a vehicle for the expression of a gene product can be assessed for particular needs.
698 citations
TL;DR: The morphology and biochemical features of apoptotic cell death are detailed, with an emphasis on discriminating it from necrosis, and specific and selective techniques which are optimal to target hallmark apoptotic features are described.
487 citations
TL;DR: Its ease of use in awake animals yields rapid and reproducible results with no sign of motor impairment, and the method was validated by demonstrating that morphine had a marked antinociceptive effect and that naloxone blocked the effect of systemic morphine in mononeuropathic rat.
460 citations
TL;DR: The isolated perfused mammalian heart preparation was established in 1897 by Oscar Langendorff and has brought many important advances in many areas including ischemia-reperfusion injury, cell-based therapy and donor heart preservation for transplant.
344 citations