Showing papers in "Journal of Pharmacological Sciences in 2022"

TL;DR: In this paper , a review highlights that ABCA1 and ABCG1 could be potential therapeutic targets for preventing atherosclerosis by regulating their expression, degradation, and localization, which can suppress cholesterol accumulation and inflammation in macrophages.

TL;DR: In this paper , the importance of zinc homeostasis based on the findings of zinc transporter functions and their signals in relation to human diseases was introduced, since the association between zinc transporters and human diseases has been recently reported using human genetics and gene knockout mouse studies.

TL;DR: DHA and Sora had the same mechanism, and the combined application of them could have a synergistic anti-tumor effect by inducing ferroptosis and inhibiting energy metabolism in HepG2 cells.

TL;DR: In this paper , the combined application of Dihydroartemisinin (DHA) and Sora had a synergistic inhibitory effect on HepG2 and SW480 cells, and DHA enhanced Sora efficacy on xenograft tumor in nude mice.

TL;DR: In this paper , the authors discuss the structural and biochemical features of ZNT10, ZIP8, and ZIP14, including transport mechanisms, regulation of expression, and pathophysiological functions.

TL;DR: In this paper, the authors discuss the structural and biochemical features of ZNT10, ZIP8, and ZIP14, including transport mechanisms, regulation of expression, and pathophysiological functions.

TL;DR: Findings support that ART triggers ferroptosis in glioblastoma and might be a potential therapeutic agent for gliOBlastoma treatment.

TL;DR: In this article , a review outlines the global efforts and outcomes of drug repurposing research for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) aggravation and heart failure.

TL;DR: In this paper, the authors investigated the renoprotective effect of isoliquiritigenin (ISL) on AKI and the role of Formyl peptide receptors 2 (FPR2) in this process.

TL;DR: In this article , the authors investigated the renoprotective effect of isoliquiritigenin (ISL) on AKI and the role of Formyl peptide receptors 2 (FPR2) in this process.

TL;DR: This review discusses how amino acids and their transporters regulate immune cell functions, with emphasis on LAT1, a transporter of large neutral amino acids, and explores the possibility of targeting amino acidtransporters to improve immune disorders and cancer immune therapies.

TL;DR: Wang et al. as discussed by the authors used human induced pluripotent stem cell (iPSC)-derived small intestinal epithelial cells as a SARS-CoV-2 infection model.

TL;DR: Evidence is provided that Pt exerts hepatoprotective effects in hepatic I/R injury by upregulating PINK1-mediated mitophagy by improving liver histology, decreasing hepatocyte apoptosis, and reducing plasma ALT and AST levels.

TL;DR: In this paper , the potential benefits and underlying mechanisms of pterostilbene (Pt), a natural component of blueberries and grapes, in preventing hepatic I/R injury were investigated.

TL;DR: In this article, the effect of Wilforlide A on RA progression and the potential mechanisms are unclear, however, the authors used the collagen-induced arthritis (CIA) mouse as an experimental model of RA.

TL;DR: In this article , the authors have reported that inflammatory cytokines and neutrophils are increased in the blood of patients with major depression, leading to depressive-like behavior. And they have found that chronic stress influences peripheral immune cells by activating the sympathetic nervous system and the hypothalamus-pituitary-adrenal gland axis.

TL;DR: In this article , the authors discuss how amino acids and their transporters regulate immune cell functions, with emphasis on LAT1, a transporter of large neutral amino acids, and explore the possibility of targeting amino acid transporter to improve immune disorders and cancer immune therapies.

TL;DR: In this article , the effect of Wilforlide A on RA progression and the potential mechanisms are unclear, however, the authors used the collagen-induced arthritis (CIA) mouse as an experimental model of RA.

TL;DR: The molecular and biological characterizations of CNNM/CorC show that they are an intriguing therapeutic target; the current status of drug development targeting these proteins is also discussed.

TL;DR: In this paper , a machine-learning approach was applied to integrate clinician knowledge into a predictive model for initial vancomycin dosing, which is a primary treatment for methicillin-resistant Staphylococcus aureus infections.

TL;DR: In this paper , the impact of FABP3, dopamine receptors, and other Fatty acid-binding proteins in the process of α-synuclein propagation and subsequent aggregate-induced cytotoxicity was studied.

TL;DR: In this article , the effects of change in intra-aortic blood volume induced by blood removal and subsequent blood transfusion on arterial stiffness and the involvement of autonomic nervous activity were assessed using an established rabbit model in the presence or absence of the ganglion blocker hexamethonium.

TL;DR: In this article , the authors investigated whether TJ-48 has a renal protective effect and its underlying mechanism in mice with adenine-induced chronic kidney disease (CKD).

TL;DR: In this paper , the impact of genetic polymorphisms on the pharmacokinetics and clinical efficacy and safety of lenvatinib, a substrate of ATP-binding transporters, in a cohort of 48 Japanese patients with hepatocellular carcinoma (HCC) was examined.

TL;DR: ABCG2 421C > A polymorphism could affect exposure to lenvatinib and the development of anorexia and the impact of genetic polymorphisms on the pharmacokinetics and clinical efficacy and safety of len vatinib in a cohort of 48 Japanese patients with HCC is examined.

TL;DR: Among the causative genes of idiopathic basal ganglia calcification (IBGC), this article focused specifically on PiT2, and its potential for a therapeutic target of IBGC.

TL;DR: Among the causative genes of idiopathic basal ganglia calcification (IBGC), this paper focused specifically on Type-III sodium-dependent phosphate transporters (PiT1 and PiT2) and its potential for a therapeutic target of IBGC.

TL;DR: The authors found that TLR2 and TLR4 agonists increased Rel, Atf3, and Cebpb and decreased Hhex in primary microglia as repeated social defeat stress.

TL;DR: In this paper , the authors used an infrared video camera to measure the spontaneous locomotor activity (SLA) of mice in their natural breeding environment, which is one of the most important behavioral indices for experimental animals.

TL;DR: In this article , five neural networks with varying E/I ratios (88/12, 84/16, 74/26, 58/42, and 48/52) were constructed by altering the ratios of glutamatergic (E) and GABA (I) neurons.