Showing papers in "Journal of the American College of Cardiology in 2015"

TL;DR: It is suggested that HCM is more common than previously estimated, which may enhance its recognition in the practicing cardiovascular community, allowing more timely diagnosis and the implementation of appropriate treatment options for many patients.

TL;DR: No significant difference between TAVR and SAVR was found for the composite rate of death from any cause, stroke, or myocardial infarction after 1 year in the NOTION trial.

TL;DR: The past, present, and future therapies to reduce ischemia/reperfusion injury are examined; few interventions have successfully passed the proof-of-concept stage.

TL;DR: Long-term sustained weight loss is associated with significant reduction of AF burden and maintenance of sinus rhythm and in multivariate analyses, weight loss and weight fluctuation were independent predictors of outcomes.

TL;DR: Presenting symptoms and physical findings of AAD have not changed significantly and more patients in both groups were managed with interventional procedures: surgery in type A and endovascular therapy in type B.

TL;DR: In patients presenting for P-PCI with multivessel disease, index admission complete revascularization significantly lowered the rate of the composite primary endpoint at 12 months compared with treating only the IRA.

TL;DR: Patients treated with percutaneous repair more commonly required surgery for residual MR during the first year after treatment, but between 1- and 5-year follow-up, comparably low rates of surgery for MV dysfunction with either per cutaneous or surgical therapy endorse the durability of MR reduction with both repair techniques.

TL;DR: CTA-verified HRP was an independent predictor of acute coronary syndrome (ACS), and the cumulative number of ACS patients with HRP(-) was similar to patients withHRP(+), as well as plaque progression detected by serial CTA.

TL;DR: The physiologic impact on the circulation of these devices and their use in specific clinical situations are reviewed and the clinical utility of mechanical circulatory support devices is reviewed, as are the American College of Cardiology/American Heart Association clinical practice guidelines.

TL;DR: Remote ischemic conditioning by repeated brief inflation/deflation of a blood pressure cuff protects against endothelial dysfunction and myocardial injury in percutaneous coronary interventions, coronary artery bypass grafting, and reperfused acuteMyocardial infarction.

TL;DR: Results show that IE incidence has increased in the United States over the past decade, and there has been a significant rise in the incidence of Streptococcus IE since the 2007 guideline revisions.

TL;DR: An accurate estimate of 10-year CHD risk can be obtained using traditional risk factors and CAC and the MESA risk score can be used to aid clinicians when communicating risk to patients and when determining risk-based treatment strategies.

TL;DR: Complications and inappropriate shock rates were reduced consistently with strategic programming and as operator experience increased, and the S-ICD demonstrated high efficacy for VT/VF.

TL;DR: In patients with NVAF at increased risk for stroke or bleeding who are candidates for chronic anticoagulation, LAAC resulted in improved rates of hemorrhagic stroke, cardiovascular/unexplained death, and nonprocedural bleeding compared to warfarin.

TL;DR: Independent of their plaque-regressive effects, statins promote coronary atheroma calcification, and these findings provide insight as to how statins may stabilize plaque beyond their effects on plaque regression.

TL;DR: As the surgical techniques for the Fontan operation have changed over the last 40 years, survival has improved, however, development of PLE and arrhythmias and the need for reoperation during long-term follow-up pose significant management challenges.

TL;DR: The exosome-rich fraction was powerfully cardioprotective in all tested models of cardiac ischemia-reperfusion injury and identified a pro-survival signaling pathway activated in cardiomyocytes involving toll-like receptor (TLR) 4 and various kinases, leading to activation of the cardiop rotective HSP27.

TL;DR: Cardiorespiratory fitness predicts arrhythmia recurrence in obese individuals with symptomatic AF and augments the beneficial effects of weight loss.

TL;DR: Among DES, second- generation devices have substantially improved long-term safety and efficacy outcomes compared with first-generation devices.

TL;DR: Fundamental principles of cardiac, vascular, and pump mechanics are discussed and illustrated to illustrate how they provide a broad foundation for understanding the complex interactions between the heart, vasculature, and device and how they may help guide future research to improve patient outcomes.

TL;DR: The results suggest that physicians should weigh the trade-off between ischemic and bleeding risk when choosing the shorter or longer duration of triple therapy.

TL;DR: In patients with severe aortic stenosis who are at increased surgical risk, the higher rate of survival with a self-expanding TAVR compared with surgery was sustained at 2 years.

TL;DR: In this article, the associations between dietary saturated fats and the risk of coronary heart disease (CHD) remain controversial, but few studies have compared saturated with unsaturated fats, and only one study compared unsaturated with saturated fats.

TL;DR: The pathophysiology, evaluation, and prognosis of secondary MR in patients with heart failure are discussed, and the evidence for the various therapeutic approaches for secondary MR is evaluated, including guideline-directed medication for left ventricular dysfunction, cardiac resynchronization therapy and revascularization when appropriate, and mitral valve surgery and transcatheter interventions.

TL;DR: Although recent studies suggest that measuring coronary artery calcification (CAC) may be superior to indirect atherosclerotic markers in predicting cardiac risk, there are limi... as mentioned in this paper.

TL;DR: The evidence supporting a multifaceted hypothesis of the natural history of atherosclerotic plaque rupture is summarized, showing the complex relationship between plaque rupture and acute coronary event risk suggested by pathology studies and confirmed by clinical investigations.

TL;DR: On the basis of the current evidence, the traditional Mediterranean-type diet, including plant foods and emphasis on plant protein sources provides a well-tested healthy dietary pattern to reduce CVD.

TL;DR: Significant ASCVD risk heterogeneity exists among those eligible for statins according to the new guidelines, and the absence of CAC reclassifies approximately one-half of candidates as noteligible for statin therapy.

TL;DR: A 2-part document describing consensus recommendations for clinical trial design and endpoint definitions to guide evaluation of transcatheter and surgical therapies for MR is described.

TL;DR: In a prospective cohort with PPCM, most women recovered; however, 13% had major events or persistent severe cardiomyopathy, and severe LV dysfunction and greater remodeling at study entry were associated with less recovery.