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Showing papers in "Journal of the American College of Cardiology in 2020"


Journal ArticleDOI
TL;DR: CVD burden continues its decades-long rise for almost all countries outside high-income countries, and alarmingly, the age-standardized rate of CVD has begun to rise in some locations where it was previously declining in high- income countries.

3,315 citations


Journal ArticleDOI
TL;DR: The current understanding of the pathogenesis, epidemiology, management and outcomes of patients with COVID-19 who develop venous or arterial thrombosis, and of those with preexistingThrombotic disease who develop CO VID-19 are reviewed.

2,222 citations


Journal ArticleDOI
TL;DR: The peer-reviewed and preprint literature pertaining to cardiovascular considerations related to COVID-19 are reviewed to highlight gaps in knowledge that require further study pertinent to patients, health care workers, and health systems.

1,484 citations


Journal ArticleDOI
TL;DR: The COVID-19 pandemic has significantly affected the U.S. health care system and the Centers for Disease Control and Prevention recommended deferral of elective cardiac procedures.

990 citations


Journal ArticleDOI
TL;DR: The novel coronavirus disease-2019 (COVID-19) has affected nearly every country worldwide and there are anecdotal observations of improved outcomes with systemic anticoagulation (AC), however, the specific outcomes are still unclear.

802 citations


Journal ArticleDOI
TL;DR: Cardiovascular disease (CVD) including coronary artery disease, atrial fibrillation, and heart failure, was more prevalent in patients with higher troponin concentrations, as were hypertension and diabetes.

532 citations


Journal ArticleDOI
TL;DR: This summary operationalizes the recommendations from the full guideline and presents a combination of diagnostic work-up, genetic and family screening, risk stratification approaches, lifestyle modifications, surgical and catheter interventions, and medications that constitute components of guideline directed medical therapy.

430 citations



Journal ArticleDOI
TL;DR: The United States is seeing a surge in cases, and local authorities have taken aggressive measures to limit its spread through social media.

379 citations



Journal ArticleDOI
TL;DR: Association of AC with in-hospital outcomes and thromboembolic findings on autopsies was associated with lower mortality and intubation among hospitalized COVID-19 patients, although not statistically significant.


Journal ArticleDOI
TL;DR: An international, multicenter cohort study including 7 hospitals in New York City and Milan of hospitalized patients with laboratory-confirmed COVID-19 who had undergone transthoracic echocardiographic (TTE) and electrocardiographic evaluation during their index hospitalization found cardiac structural abnormalities were present in nearly two-thirds of patients with myocardial injury.


Journal ArticleDOI
TL;DR: The structured use of serial cardiac troponin has the potential to facilitate risk stratification, help make decisions about when to use imaging, and inform stage categorization and disease phenotyping among hospitalized COVID-19 patients.

Journal ArticleDOI
TL;DR: It is critical for cardiologists, diabetologists, nephrologists, and primary care physicians to be familiar with SGLT2i, as their use is now being studied in the treatment of heart failure and chronic kidney disease, even in patients without diabetes.

Journal ArticleDOI
TL;DR: This research presents a state-of-the-art virtual reality system that automates the very labor-intensive and therefore time-heavy and expensive and therefore expensive and time-consuming and expensive process of designing and implementing virtual reality systems.


Journal ArticleDOI
TL;DR: Baseline lipoprotein(a) levels and corrected LDL-C levels and their reductions by alirocumab predicted the risk of MACE after recent ACS, which suggests that lipoproteins should be an independent treatment target after ACS.

Journal ArticleDOI
TL;DR: FH prevalence in the general population was similar using genetic versus clinical diagnoses, and FH prevalence is 10-fold higher among those with IHD, 20-fold Higher among thoseWith premature IHD and 23-foldHigher among thosewith severe hypercholesterolemia.

Journal ArticleDOI
TL;DR: An update on the evidence relating salt to health, with a particular focus on blood pressure and cardiovascular disease, as well as the potential mechanisms, is provided.

Journal ArticleDOI
TL;DR: During the first phase of the COVID-19 pandemic, there was a marked decline in acute cardiovascular hospitalizations, and patients who were admitted had shorter lengths of stay, which substantiate concerns that acute care of cardiovascular conditions may be delayed, deferred, or abbreviated during the pandemic.

Journal ArticleDOI
TL;DR: Mechanistic links between inflammation and HF are described, traditional and novel inflammatory biomarkers are discussed, and the latest evidence from clinical trials of anti-inflammatory therapies is summarized.

Journal ArticleDOI
TL;DR: This review comprehensively examines the pathogenesis of preeclampsia with a specific focus on the mechanisms underlying the clinical features and identifies potential therapeutic targets for improved treatment and, ultimately, outcomes of this prevalent disease.

Journal ArticleDOI
TL;DR: Major arterial or venous thromboembolism, major cardiovascular adverse events, and symptomatic venousThromboEmbolism occurred with high frequency in patients with COVID-19, especially in the intensive care setting, despite a high utilization rate of thromboprophylaxis.

Journal ArticleDOI
TL;DR: In patients presenting with STEMI and concurrent COVID-19 infection, there is a strong signal toward higher thrombus burden and poorer outcomes, which supports the need for establishing CO VID-19 status in all STEMI cases.

Journal ArticleDOI
TL;DR: The LAAO Registry has enrolled >38,000 patients implanted with the device, and patients were generally older with more comorbidities than those enrolled in the pivotal trials; however, major in-hospital adverse event rates were lower than reported in those trials.

Journal ArticleDOI
TL;DR: Peripartum cardiomyopathy is a form of systolic heart failure affecting young women toward the end of pregnancy or in the months following delivery, and occurrence is higher in African-American women and in women with older maternal age, hypertensive disorders of pregnancy, and multiple gestation pregnancies.


Journal ArticleDOI
TL;DR: Irregular sleep duration and timing may be novel risk factors for CVD, independent of traditional CVD risk factors and sleep quantity and/or quality.