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Showing papers in "Journal of Thrombosis and Haemostasis in 2005"


Journal ArticleDOI
TL;DR: A definition of major bleeding in non‐surgical patients was developed that should be applicable to studies with all agents that interfere with hemostasis, including anticoagulants, platelet function inhibitors and fibrinolytic drugs.

3,084 citations


Journal ArticleDOI
TL;DR: In addition to its primary role of providing scaffolding for the intravascular thrombus and also accounting for important clot viscoelastic properties, fibrin(ogen) participates in other biologic functions involving unique binding sites, some of which become exposed as a consequence of fibrIn formation.

1,489 citations


Journal ArticleDOI
TL;DR: Roles for PARs in blood vessel formation and other processes during embryonic development are emerging, and whether these reflect new roles for the coagulation cascade and/or PAR signaling to other proteases remains to be explored.

960 citations


Journal ArticleDOI
TL;DR: BAY 59‐7939 inhibited endogenous FXa more potently in human and rabbit plasma than rat plasma, correlating with the 14‐fold lower IC50 ofFXa inhibition in rabbit compared with rat plasma; this may suggest a correlation between FXa inhibition and antithrombotic activity.

585 citations


Journal ArticleDOI
TL;DR: High‐intensity warfarin was not superior to standard treatment in preventing recurrent thrombosis in patients with APS and was associated with an increased rate of minor hemorrhagic complications.

515 citations


Journal ArticleDOI
TL;DR: The development and testing of specific PAI‐1 antagonists will enable basic and clinical investigators the opportunity to test the hypothesis that vascular PAI-1 excess promotes the development of intravascular thrombosis and atherosclerosis.

444 citations


Journal ArticleDOI
TL;DR: VTE is a common, lethal disease that recurs frequently and causes serious long‐term complications, and to improve survival and prevent complications, VTE occurrence must be reduced.

412 citations


Journal ArticleDOI
TL;DR: A flow cytometric analysis of VASP phosphorylation seems to be a suitable test to evaluate the efficacy of clopidogrel treatment and showed that one‐third of the patients treated appeared to be ‘unprotected’ by this therapy.

400 citations


Journal ArticleDOI
TL;DR: This meta‐analysis of prospective and retrospective studies demonstrates a modest association of homocysteine with venous thrombosis and provides some support for causality with the MTHFR 677TT genotype.

400 citations


Journal ArticleDOI
TL;DR: It appears, however, that most of the variability observed in patients response to warfarin may be attributed to variability in the VKOR gene.

395 citations


Journal ArticleDOI
TL;DR: In this paper, a multicenter, parallel-group, double-blind study, 1973 patients undergoing total hip or knee replacement were randomized to 6-10 days of oral Dabigatran etexilate (50, 150,mg twice daily, 300,mg once daily, 225, mg twice daily), starting 1-4 h after surgery, or subcutaneous enoxaparin (40 mg once daily) starting 12 h prior to surgery.

Journal ArticleDOI
TL;DR: This review summarizes recent developments in the understanding of the molecular basis of platelet activation by two distinct types of surface receptor, the immunoglobulin GPVI, and the integrin αIIbβ3.

Journal ArticleDOI
TL;DR: The strongest evidence that homocysteine plays a causal role in atherothrombosis has been provided by studies using animal models, and a key vascular phenotype observed in hyperhomocysteinemic animals is endothelial dysfunction, manifested by decreased bioavailability of endothelium‐derived nitric oxide.

Journal ArticleDOI
TL;DR: This work presents a meta-analysis of Platelet Function Studies and Hemostasis in relation to Thrombosis and Haemostasis that shows clear trends in prognosis and in particular in cases of high-risk individuals, where the prognosis for survival is poorer for those with high levels of Aspirin resistance.

Journal ArticleDOI
TL;DR: It is suggested that the use of a standardized questionnaire and bleeding score may be useful for the identification of subjects requiring laboratory evaluation for type 1 von Willebrand disease.

Journal ArticleDOI
TL;DR: Studies with transgenic mice have revealed a functional role for PAI‐1 in wound healing, atherosclerosis, metabolic disturbances such as obesity and insulin resistance, tumor angiogenesis, chronic stress, bone remodeling, asthma, rheumatoid arthritis, fibrosis, glomerulonephritis and sepsis.

Journal ArticleDOI
TL;DR: In all three categories, the incidence rates were greater for women and for blacks, and the greater incidence among women and blacks is comparable with their increased risk for other autoimmune disorders.

Journal ArticleDOI
TL;DR: The goals of this review are to consider mechanisms of endothelial cell heterogeneity, discuss the bench‐to‐bedside gap in endothelial biomedicine, revisit definitions for endothelium activation and dysfunction, and propose new goals in diagnosis and therapy.

Journal ArticleDOI
TL;DR: Oral administration of 2.5–10 mg b.i.d. of BAY 59‐7939, early in the postoperative period, showed potential efficacy and an acceptable safety profile, similar to enoxaparin, for the prevention of VTE in patients undergoing elective total knee replacement.

Journal ArticleDOI
TL;DR: The steps and mechanisms by which VEGF‐A induces the formation of new blood vessels and will provide an initial classification of the abnormal blood vessels that form in pathological angiogenesis are reviewed.

Journal ArticleDOI
TL;DR: The final consensus guidelines, together with the data of the first 36 trauma patients treated in Israel, provide a valuable tool for physicians using rFVIIa for the expanding off‐label clinical uses.

Journal ArticleDOI
TL;DR: The roles of P‐sel and TF‐positive MPs are discussed and strategies to modulate hemostasis by modulating the P‐sels, TF, coagulation triad are highlighted.

Journal ArticleDOI
TL;DR: Low quality treatment with VKA, which is a common condition, is related to the occurrence of the PTS in patients with DVT, and strategies aimed at improving the quality of long‐term anticoagulation might have the potential to reduce the incidence of this complication.

Journal ArticleDOI
TL;DR: While FXI and FIX deficiencies were indistinguishable in the carotid artery injury model, there was a marked difference in a tail‐bleeding‐time assay, suggesting therapeutic inhibition of FXI may be a reasonable strategy for treating or preventing thrombus formation.

Journal ArticleDOI
TL;DR: Proximal DVT, male gender, and high D‐dimer levels are independently associated with the development of post‐thrombotic syndrome in patients with a first symptomatic DVT.

Journal ArticleDOI
TL;DR: The purpose of this article is to provide insight into the thrombin molecular recognition events at the heart of hemostasis through the specific cleavage of at least a dozen substrates.

Journal ArticleDOI
TL;DR: This review will also detail experimental systems where coated‐platelets are generated as a result of other agonist(s), and the putative physiological consequences of coated‐ platelet formation will be discussed.

Journal ArticleDOI
TL;DR: The rate of new TECs in HIT patients is low after start of lepirudin treatment, and the rate of major bleeding may be reduced by reducing the starting dose to 0.1 mg kg−1‰h−1.

Journal ArticleDOI
TL;DR: The high magnitude of r and the high significance of the prediction equation demonstrate the high efficacy of the predictions of TAT thrombin generation by the use of TEG® TTG.

Journal ArticleDOI
TL;DR: Without thrombosis prophylaxis the risk for recurrent symptomatic VTE is substantial during the whole period of pregnancy in women with previous VTE, reflecting the very high risk during the postpartum period.