scispace - formally typeset
Search or ask a question

Showing papers in "Journal of Thrombosis and Haemostasis in 2007"


Journal ArticleDOI
TL;DR: This study showed no significant differences in baseline CEC counts or VWF levels between the AR, CS and RFV, however, PCI was associated with a significant increase in CECs, but not VWF, across all three sampling sites, and this study cannot presume that the increased CEC numbers represent specific coronary artery endothelial shedding.

1,286 citations


Journal ArticleDOI
TL;DR: This data indicates that venous thrombosis in women under the age of 40 is more prone to bleeding than in men, and the incidence ofVT among women aged 40 and over is higher than in women aged 50 and over.

1,201 citations


Journal ArticleDOI
TL;DR: Dabigatran etexilate (220 mg or 150‰mg) was at least as effective as enoxaparin and had a similar safety profile for prevention of VTE after total knee replacement surgery.

991 citations


Journal ArticleDOI
TL;DR: Thienopyridines are metabolized to active metabolites that irreversibly inhibit the platelet P2Y12 adenosine diphosphate receptor, and the pharmacodynamic response to clopidogrel is more variable than the response to prasugrel.

694 citations


Journal ArticleDOI
TL;DR: Findings indicate that a simple fibrinogen measurement can anticipate the risk of severe bleeding in PPH.

617 citations



Journal ArticleDOI
TL;DR: In this article, the authors investigated the association between clinically manifest venous thromboembolism (VTE) and procoagulant properties of circulating microparticles (MP) isolated from blood of unselected pancreatic and breast adenocarcinoma patients' consecutive subjects, who presented with ultrasound or CT-scan confirmed VTE, and healthy subjects.

490 citations


Journal ArticleDOI
TL;DR: ROTEM is a point‐of‐care device that rapidly detects systemic changes of in vivo coagulation in trauma patients, and it might be a helpful device in guiding transfusion.

479 citations


Journal ArticleDOI
TL;DR: Compared to other D‐dimer assays, the ELFA, microplate ELISA and latex quantitative assays have higher sensitivity but lower specificity, resulting in a more confident exclusion of the disease at the expense of more additional imaging testing.

416 citations


Journal ArticleDOI
TL;DR: The uremic solute indoxyl sulfate enhances ROS production, increases NAD(P)H oxidase activity, and decreases glutathione levels in endothelial cells, and induces oxidative stress by modifying the balance between pro‐ and antioxidant mechanisms in endotocyte cells.

365 citations


Journal ArticleDOI
TL;DR: An accurate calculation of risk would allow direct assessment of whether the effects of non‐O status on thrombosis risk are of the magnitude predicted by its effect on von Willebrand factor/FVIII levels.

Journal ArticleDOI
TL;DR: Apixaban in doses of 2.5 mg b.i.d. or 5’h after surgery with apixaban or enoxaparin has a promising benefit–risk profile compared with the current standards of care following TKR, and a significant dose‐related increase in the incidence of total adjudicated bleeding events was noted.

Journal ArticleDOI
TL;DR: The system described in this article could represent an attractive new generation of therapeutic delivery vehicle for treatment of cardiovascular diseases, as it combines long‐term in vivo therapeutic benefit (localized bioactive VEGF for 1–2 weeks) with minimally invasive delivery.

Journal ArticleDOI
TL;DR: This review describes key serpins important in the regulation of these pathways: antithrombin, heparin cofactor II, protein Z‐dependent protease inhibitors, α1‐protease inhibitor, protein C inhibitor, α2‐antiplasmin and plasminogen activator inhibitor‐1.

Journal ArticleDOI
TL;DR: Information on the structural origins of clot stability is necessary for understanding the functions and pathology of fibrin clots and thrombi, but is also important for interpreting correctly the results of a variety of clinical diagnostic systems and technologies used daily to assess the hemostatic potential in patients.

Journal ArticleDOI
TL;DR: In 2001, the International Society on Thrombosis and Haemostasis Sub-Committee of the Scientific and Standardisation Committee (SSC) on Disseminated Intravascular Coagulation proposed that the working definition of DIC be delineated into two phases.

Journal ArticleDOI
TL;DR: Clinically relevant reductions in bleeding frequency during prophylaxis as compared to conventional on‐demand therapy were achieved without raising safety concerns, providing evidence for the concept of secondary rFVIIa prophyllaxis in inhibitor patients with frequent bleeds.

Journal ArticleDOI
TL;DR: The context in which thrombin acts during hemostasis is described and the roles that its exosites and cofactors play in directing throm bin function are explained, and the concept of cofactor competition is developed.

Journal ArticleDOI
TL;DR: VASP phosphorylation analysis can evaluate the individual response to clopidogrel loading dose prior to PCI and predict postprocedural MACE.

Journal ArticleDOI
TL;DR: The spectrum of extracellular matrix proteins and cell–matrix adhesion receptors (particularly integrins) that are likely to contribute to angiogenesis are surveyed and what is known and not known about the roles of each are discussed.

Journal ArticleDOI
TL;DR: The method provided a suitable tool for analyzing the granule proteome of patients with storage pool deficiencies and identified 284 non‐redundant proteins, 44 of which appear to be new α‐granule proteins, on the basis of a literature review.

Journal ArticleDOI
TL;DR: These findings suggest surface levels of GPVI, GPIbα and GPV may be controlled by distinct mechanisms involving ADAM10 and/or ADAM17.

Journal ArticleDOI
TL;DR: Reticulated platelets are associated with diminished antiplatelet effects of aspirin and increased aspirin resistance, possibly because of increased reactivity, and uninhibited COX‐1 andCOX‐2 activity.

Journal ArticleDOI
TL;DR: Clinical correlations showed that HIPA‐negative/EIA‐positive patients did not develop thrombosis and had reasons other than HIT to explainThrombocytopenia, and the anti‐PF4/heparin EIA has high sensitivity for HIT, but only about half of EIA‐ positive patients are likely to have HIT.

Journal ArticleDOI
TL;DR: Thrombin generation is a powerful tool to probe overall plasma coagulability and can be used as a “spatially aggregating force” to establish Plasma Coagulation Index (PCI) levels.

Journal ArticleDOI
TL;DR: These data demonstrate that both γ‐glutamyl carboxylation and serine phosphorylation of MGP contribute to its function as a calcification inhibitor and that MGP may inhibit calcification via binding to VSMC‐derived vesicles.

Journal ArticleDOI
TL;DR: A high interindividual variability of response to clopidogrel associated with adverse cardiovascular outcome is suggested and different clinical factors are considered to influence a persistent residual platelet aggregation despite conventional antiplatelet therapy.

Journal ArticleDOI
TL;DR: This investigation shows that air pollution is associated with changes in the global coagulation function, suggesting a tendency towards hypercoagulability after short‐term exposure to air pollution.

Journal ArticleDOI
TL;DR: AAV8 and 9 result in significantly higher FIX expression levels and have a reduced proinflammatory risk in comparison with lentiviral vectors, which has implications for gene therapy for heart disease.

Journal ArticleDOI
TL;DR: It is speculated that APC variants with reduced anticoagulant action but normal cytoprotective actions hold the promise of reducing bleeding risk because of attenuated anticogulant activity while reducing mortality based on direct cytoprotsective effects on cells.