Showing papers in "Journal of Thrombosis and Haemostasis in 2009"

TL;DR: Modalities for blood collection and processing are fully delineated and the choice of tests is limited to dRVVT and a sensitive aPTT and the interpretation of the results in general and in particular situations is reported.

TL;DR: The process of and factors mediating platelet–platelet and platelet-leukocyte interactions in inflammatory and immune responses are discussed, with the roles of P‐selectin, chemokines and Src family kinases being highlighted.

TL;DR: This review summarizes the current knowledge of platelet Ca2+ homeostasis with a focus on the newly identified Ca2- entry mechanisms.

TL;DR: Available scales and evidence to support their utility to diagnose PTS and to classify its severity were reviewed and discussed at the Control of Anticoagulation Subcommittee of the International Society on Thrombosis and Haemostasis (Vienna, July 2008).

TL;DR: This review includes novel proteins such a thrombin‐activatable fibrinolysis inhibitor (TAFI) and discusses new insights into molecular mechanisms obtained from the rapidly growing knowledge of crystal structures of proteins.

TL;DR: This calibrated‐bead strategy allowed full long‐term control of the FCM‐based microparticle protocol and reproducible PMP counts over time and opens the way for multicenter studies.

TL;DR: It is demonstrated that increasing time with a FVIII below 1 IU dL−1 is associated with increased total bleeds and hemarthroses, and has important implications for the management of patients with severe hemophilia.

TL;DR: This work chronologically review the increased understanding of protein synthetic responses in platelets and discusses how the field may evolve over the next decade.

TL;DR: The most important aspects of patient management are a high index of suspicion and a careful history of drug exposure in an individual who presents with acute, often severe thrombocytopenia of unknown etiology.

TL;DR: If successful, the cardiovascular inflammation reduction trial (CIRT) would both confirm the inflammatory hypothesis of atherothrombosis and open novel approaches to the treatment and prevention of cardiovascular disorders.

TL;DR: There are many weak genetic risk factors, including fibrinogen, factor XIII and factor XI variants, and the majority of carriers will never develop thrombosis.

TL;DR: The vascular stress test of pregnancy identifies women with a previously unrecognized at risk vascular system and promotes the development of preeclampsia, a pregnancy‐specific syndrome characterized by hypertension, proteinuria and edema that resolves on delivery of the placenta.

TL;DR: In this multicenter study, the detection of IgG antibodies that are directed against domain I of beta2GPI proved to be more strongly associated with thrombosis and obstetric complications than those detected using the standard anti‐beta2G PI antibody assay.

TL;DR: The data indicate that P2Y12 is targeted by ticagrelor via a mechanism that is non‐competitive with ADP, suggesting the existence of an independent receptor‐binding site for CPTPs.

TL;DR: After 6’months, additional CDT increased iliofemoral patency from 36% to 64%.

TL;DR: Randomized administration of fibrinogen concentrate significantly improved maximum clot firmness and reduced the requirement for postoperative transfusion.

TL;DR: Intensified inflammatory activation may lead to local proteolysis, plaque rupture, and thrombus formation, triggering ischemia and infarction and anti‐inflammatory therapy may be useful to control disease activity.

TL;DR: Unraveling the dynamics of platelet aggregation and thrombus formation in vivo requires consideration of the cooperative interplay between rheological‐ and soluble agonist‐dependent Platelet aggregation mechanisms.

TL;DR: Therapy for prevention of bleeding during surgery in patients with severe FXI deficiency consists of plasma, factor XI concentrates, fibrin glue and antifibrinolytic agents, and recombinant factor VIIa is useful.

TL;DR: Results of the review demonstrate that the Villalta scale is a reliable and valid measure of PTS in patients with previous, objectively confirmed DVT, and is acceptable to research subjects and research personnel, and shows responsiveness to clinical change in PTS.

TL;DR: Dalteparin is effective in decreasing the recurrence of placental‐mediated complications in women without thrombophilia, and these results require confirmation in further randomized trials.

TL;DR: Cancer patients with recurrent VTE have a short median survival, and Escalating the dose of LMWH can be effective for treating cases that are resistant to standard, weight‐adjusted doses of LM WH or a VKA.

TL;DR: A large, detailed, global survey of light transmission aggregometry practices shows a very high variability in LTA practices worldwide, and, as a consequence, methodological standardization is necessary.

TL;DR: Current methods to define EPC in the human system are reviewed and approaches to define better the cell populations involved in neoangiogenesis are suggested.

TL;DR: The Condensed MCMDM-1VWD Bleeding Questionnaire for von Willebrand disease generation and validation and quantitation of bleeding symptoms in children or a pla telet function disorder are validated.

TL;DR: The TF:FVIIa complex contributes to tumor growth by activating PAR2 and in endotoxemia and sepsis, TF‐dependent thrombin generation and activation of PAR1 on dendritic cells enhance inflammation.

TL;DR: Acquired fibrinogen deficiency seems to be the leading determinant in dilutional coagulopathy, and ex vivo addition corrected the coagULopathy completely.

TL;DR: The higher frequencies of the −308G>A polymorphism in TNF‐α and −1082A>G in IL‐10 in inhibitor patients confirmed the earlier published data.

TL;DR: Patients with cardiovascular events are at a short‐term increased risk of venous thromboembolism, as the study is non‐randomized residual confounding cannot be excluded.

TL;DR: The clinical usefulness of the platelet aggregation test for the diagnosis of heparin-induced thrombocytopenia and its role in recognition, treatment, and prevention are reviewed.