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Showing papers in "Kidney International in 1984"


Journal ArticleDOI
TL;DR: It is shown that despite a normal salt intake, mesangial injury hastened the onset of hypertension, but only in rats genetically predisposed to hypertension (S FIC at 14 weeks).

672 citations


Journal ArticleDOI
TL;DR: Examination for interactions among variables revealed that glomerular sclerosis and cellular crescents had a synergistic effect which augmented the prognostic information derived from analysis of tubular atrophy alone, and chronicity items considered individually, as well as in the composite CI, were highly predictive of renal failure outcome.

659 citations


Journal ArticleDOI
TL;DR: Drug metabolism, steroid hormone hydroxylations, renal gluconeogenesis as well as renal choline and triglyceride metabolism may be better understood by the knowledge of their precise localization along the nephron.

472 citations



Journal ArticleDOI
TL;DR: Both MBP and age significantly influenced BCr, suggesting that an accelerated loss of renal function is observed primarily because of the impact exerted by individuals with blood pressures in the hypertensive range.

336 citations


Journal ArticleDOI
TL;DR: It is demonstrated that human kidney cortex, explanted into serum-free hormonally defined growth medium gives rise to a primary culture of kidney epithelial cells of homogeneous morphology capable of hemicyst formation.

316 citations


Journal ArticleDOI
TL;DR: Renal function and blood pressure were assessed in 52 renal allograft donors 10 years or more following uninephrectomy, and their current function compared to their pre-unineph rectomy function as well as to age- and sex-matched control subjects consisting of inpatient potential renal donors and a normal "outpatient" population.

304 citations


Journal ArticleDOI
TL;DR: Results suggest that inhibition of erythroid, but not granulocytic, progenitor cell formation, in addition to a relative erythropoietin deficiency, are the primary factors responsible for the anemia of chronic renal failure.

282 citations


Journal ArticleDOI
TL;DR: The occurrence of symptomatic ischemic heart disease far exceeded the presence of significant atherosclerotic coronary artery narrowing and it is suggested that this may result from several dialysis-associated alterations in oxygen delivery and myocardial oxygen consumption.

257 citations


Journal ArticleDOI
TL;DR: Recurrent dialysis with new cuprophane and cellulose acetate membranes leads to a decrease in pre-dialysis and "rebound leukocytosis" neutrophil count, as well as a more intense activation of complement and an enhanced endogenous clearance of products of complement activation.

228 citations


Journal ArticleDOI
TL;DR: This editorial focuses on the renal hemodynamic influences exerted by the RAS as a local regulatory mechanism and the possibility that locally formed angiotensin II (All) may participate as an important modulator of renal vascular tone.

Journal ArticleDOI
TL;DR: The CAPD patients maintained albumin homeostasis through decreased albumin catabolism and increased synthesis, and all major albumin pools were maintained despite massive albumin loss.

Journal ArticleDOI
TL;DR: Methods modified from those of Kreisberg, Hoover, and Karnovsky are described, in which relatively homogenous cultures of epithelial and/or mesangial cells are obtained, which can be easily passaged, and in which the cells maintain the characteristics found in the explants.

Journal ArticleDOI
TL;DR: A 41-year-old black man was admitted to the Massachusetts General Hospital (MGH) because of shortness of breath and developed musculoskeletal pain thought to be secondary to degenerative joint disease.

Journal ArticleDOI
TL;DR: It is suggested that the kidney accumulates platinum in part by transport or specific binding to the base transport system in the kidney and biotransforms it intracellularly.


Journal ArticleDOI
TL;DR: The early alterations at the level of the proximal tubule of the human kidney caused by the three most currently used aminoglycosides, gentamicin, tobramycin, and amikacin, were studied.


Journal ArticleDOI
TL;DR: The results suggest that the lesion of TAL cells that develops during perfusion of the isolated kidney is influenced by the work of cellular transport.

Journal ArticleDOI
TL;DR: Both bumetanide and furosemide showed delayed absorption causing attainment of peak urinary excretion rates of diuretic two- to threefold lower than in normal subjects, which may contribute to the "resistance" to oral doses of diUREtics observed clinically even though no quantitative malabsorption of drug occurs.

Journal ArticleDOI
TL;DR: In dialysis patients who fail to develop anti-HBs after three doses of vaccine, a fourth vaccination is recommended after 12 months and a fifth vaccination only led to seroconversion, when brief or borderline anti- HBs could already be demonstrated previously.

Journal ArticleDOI
TL;DR: Values for BGP indicate that plasma levels of BGP reflect bone formation in uremia and predict underlying bone histology, and correlations between BGP and cellular and non-cellular parameters of bone formation are significant.

Journal ArticleDOI
TL;DR: It is concluded that congestion of the outer medulla is a key event in ischemic renal failure, its occurrence is coincidental with the reduction in deep nephron perfusion and urinary concentrating power in the early and maintenance phase and its disappearance heralds the restoration of deep neephron perfusions and urinary concentrate ability in the recovery phase.

Journal ArticleDOI
TL;DR: It is concluded that demonstration of circulating macromolecular IgA in patients with renal hematuria is of diagnostic value and that antigenetic similarities between the circulating and the mesangial macromolcule IgA suggest that dimeric IgA1 is deposited in the mesagium of patients with primary IgA nephropathy.

Journal ArticleDOI
TL;DR: It is indicated that the tissue hydration state has a strong influence on changes in PV during fluid removal and the subsequent repletion of PV, with special reference to the tissue Hydration before UF.

Journal ArticleDOI
TL;DR: Suitable and comprehensive controls and treatment can arrest growth retardation in the great majority of children with CRF after the first few years of life, regardless of their GFR.

Journal ArticleDOI
TL;DR: In this paper, the authors evaluated the diagnostic accuracy of ultrasonic echo-Doppler velocimetry for the noninvasive diagnosis of renal artery stenosis, which was found if one or more of the following abnormal hemodynamic parameters were found by Doppler velocity: (1) peak blood velocity greater than 100cm · sec -1 in a focal area along the length of a renal artery, (2) absence of blood velocity during diastole, (3) absence and absence of any detectable blood velocity denoting occlusion, or (4)

Journal ArticleDOI
TL;DR: The prognosis for subjects with APKD is much better than most reports suggest and can be estimated from the time-to-event data presented.

Journal ArticleDOI
TL;DR: In this paper, the renal cortex and outer stripe of outer medulla were analyzed in rats during ischemia and 2hr after blood reflow and showed that irreversible ischemic damage correlates with persistent abnormalities of phosphatidylcholine metabolism and persistent elevations of free fatty acids (FFA) and diacylglycerol (DG).

Journal ArticleDOI
TL;DR: It is concluded that peritoneal dialysis effluent opsonic activity predicts which CAPD patients are at an increased risk to develop S. epidermidis peritonitis.