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Showing papers in "Kidney International in 1990"


Journal ArticleDOI
TL;DR: A 42-year-old woman with a mild sensorineural hearing loss bilaterally, and a family history of renal disease, a diagnosis of hereditary nephritis was made and she entered the feasibility phase of the Modification of Diet in Renal Disease (MDRD) Study.

561 citations


Journal ArticleDOI
TL;DR: Results indicate that aortic wall compliance is decreased in HD, resulting in an increase in the pulsatile component of arterial pressure.

384 citations


Journal ArticleDOI
TL;DR: The peritoneal mesothelial cell may be pivotal in the initiation of the inflammatory response during peritonitis and its establishment in culture will provide the basis for an in vitro model of peritoneAL inflammation.

383 citations


Journal ArticleDOI
TL;DR: In the present review the possibility of abnormal transit of plasma proteins through the glomerular capillary membrane being the key factor in glomerulosclerosis will be addressed.

383 citations


Journal ArticleDOI
TL;DR: The results show that TGF-beta is unique among growth factors in its regulatory effects on mesangial cell proteoglycan production, which could mediate the accumulation of proteoglycans in the extracellular matrix and predispose the kidney to development of glomerulosclerosis.

363 citations


Journal ArticleDOI
TL;DR: Cyclosporine is a potential inducer for endothelin release andendothelin appears to have a pivotal role in pathophysiology of cyclosporin-induced acute renal vasoconstriction and glomerular dysfunction.

357 citations


Journal ArticleDOI
TL;DR: A rational approach to the treatment of renal bone disease requires a basic understanding of the anatomic physiology of bone, the pathophysiologic effects of renal failure on mineral metabolism and bone, and the various available therapeutic modalities.

350 citations


Journal ArticleDOI
TL;DR: The concomitant presence of IL-1 and TNF alpha in the plasma of long-term HD patients could be responsible for some of the clinical features observed in these patients, and provides strong evidence favoring the concept that HD can be assimilated to a recurrent acute-phase inflammatory response.

348 citations


Journal ArticleDOI
TL;DR: It is concluded that loss of the osmotic driving force and increased fluid re absorption (possibly due to increased lymphatic reabsorption) are the two major causes of permanent loss of UFC in CAPD patients.

334 citations


Journal ArticleDOI
TL;DR: In 2,000 hours of citrate CAVHD in eleven critically patients, this system has proved smooth, practical and effective, and has minimized the risks of hemorrhage and thrombocytopenia encountered with heparin use.

305 citations


Journal ArticleDOI
TL;DR: The data from this series confirm that soft tissue calcification is a significant problem in young patients with advanced renal disease, with clinically significant, and in some cases fatal consequences.

Journal ArticleDOI
TL;DR: The results suggest that additional investigations may ultimately determine how cholesterol deposition, altered fatty acid metabolism, macrophages, and increased glomerular pressure might combine to cause chronic progressive renal injury.

Journal ArticleDOI
TL;DR: It is established for the first time that HMC are able to generate significant oxygen radicals in response to IL-1α and TNF-α, in amounts comparable to that produced by monocytes, which may be relevant to the pathogenesis of human glomerulonephritis.

Journal ArticleDOI
TL;DR: Evaluation of GA in all the 42 pediatric biopsies with initial MCD further showed that in 23 patients GA was equal to or smaller than the CONT average, which is significantly larger than the age-matched MCD or CONT groups.

Journal ArticleDOI
TL;DR: The renal handled citrate has been increasingly recognized as an important endogenous inhibitor of calcium nephrolithiasis and the mechanisms of citrate transport in the proximal tubule are discussed.


Journal ArticleDOI
TL;DR: The results indicate that both vasculitis-associated CGN and idiopathic CGN are associated with autoantibodies against myeloid lysosomal enzymes, which places these disorders within one spectrum of diseases.

Journal ArticleDOI
TL;DR: Together, assays for AGBMA and ANCA are important in the diagnosis and management of rapidly progressive glomerulonephritis and may help its further classification.

Journal ArticleDOI
TL;DR: Renal and hormonal responses were studied in a group of healthy individuals fed, in random order, for three weeks, a vegetable protein diet, an animalprotein diet, or an animal protein diet supplemented with fiber, all containing the same amount of total protein.

Journal ArticleDOI
TL;DR: These cell lines have characteristics most consistent with a proximal tubular origin and bear characteristics of accessory cells such as processing and presentation of antigen and TNF-alpha gene expression, suggesting that PT have the capacity to participate in the pathogenesis of immune renal injury.

Journal ArticleDOI
TL;DR: This review will examine the association of HBV infection with these major syndromes, as well as their salient features, and distinguishing clinical characteristics.

Journal ArticleDOI
TL;DR: The results indicate that interaction between blood and regenerated cellulose membranes leads to accelerated net protein breakdown, and that the protein catabolic effect of blood-membrane contact depends on the biochemical properties of dialyser.

Journal ArticleDOI
TL;DR: The results indicate that the early high incidence of hypertension in ADPKD correlates with the renal structural abnormalities in this disorder.

Journal ArticleDOI
TL;DR: It is suggested that interstitial T cells and monocytes may be important determinants of pathogenesis and progression of lupus nephritis and may be the major factor in chronic injury.

Journal ArticleDOI
TL;DR: There was a significant positive correlation between both pre- dialysis and post-dialysis plasma bicarbonate and the muscle valine concentration, suggesting that mild acidosis may be causally related to the inbalance of the branched-chain amino acids in uremia.

Journal ArticleDOI
TL;DR: It is concluded that transcription of mRNA for IL-1 beta and TNF alpha during HD is primarily caused by complement activation by Cup, but that LPS or other factors are required for translation of IL- 1 beta andTNF alpha mRNA transcribed during HD.

Journal ArticleDOI
TL;DR: Carnitine treatment was associated with a significant drop in pre-dialysis concentrations of serum urea nitrogen, creatinine and phosphorus, and no significant changes in any of these variables were noticed in the placebo group.

Journal ArticleDOI
TL;DR: The data demonstrate that IL-6 acts as an autocrine growth factor for MC and may also be one of the autocrine signals leading to mesangial cell proliferation in vivo.

Journal ArticleDOI
TL;DR: It is suggested that albuterol and insulin with glucose are equally efficacious in lowering plasma potassium in uremic patients, and that the hypokalemic effects of the two drugs is additive.