Showing papers in "Kidney International in 2000"

TL;DR: The overall risk of hip fracture among Caucasian patients with ESRD is considerably higher than in the general population, independent of age and gender.

TL;DR: It is suggested that traditional risk factors are inadequate predictors of coronary heart disease in hemodialysis patients, while other factors did not correlate with atherosclerotic cardiovascular diseases in this cross-sectional study.

TL;DR: Although DWGF is a major cause of graft loss, the risk has declined substantially since 1990 and attention to atherosclerotic risk factors may be the most important challenge to further improve the longevity of patients with successful renal transplants.

TL;DR: High triglycerides and low HDL cholesterol, but not low-density lipoprotein cholesterol, predict an increased risk of renal dysfunction and the treatment of these lipid abnormalities may decrease the incidence of early renal disease.

TL;DR: Patients with ESRD treated by dialysis have higher annual mortality rates caused by sepsis compared with the GP, even after stratification for age, race, and DM, and differences between groups decreased but retained their magnitude.

TL;DR: The hypothesis that patients who reach end-stage renal disease should receive a renal transplant as early as possible in order to enhance their chances of long-term survival is supported.

TL;DR: There are strong correlations between glomerular number (direct) and size (inverse) with LBW in this cohort and endowment with decreased nephron numbers may be a risk factor for hypertension and the rate of progression of renal disease.

TL;DR: Higher levels of depressive affect in ESRD patients treated with HD are associated with increased mortality, and the effects of depression on patient survival are of the same order of magnitude as medical risk factors.

TL;DR: It is shown that ROS may activate aldose reductase, induce diacylglycerol, activate PKC, induce advanced glycation end product formation, and activate the pleiotropic transcription factor nuclear factor- kappa B (NF-kappaB).

TL;DR: This review presents the current knowledge about the functions of BMPs during skeleton development as well as in many other biologic processes.

TL;DR: Detailed information concerning molecular and cellular aspects of drug transporters expressed in the kidney has facilitated studies of the mechanisms underlying renal disposition as well as transporter-mediated drug interactions.

TL;DR: Clinical data comparing ACEI and AT1RA therapy in renal disease indicate that AT1RAs have equivalent effects to ACEI on the major determinants of CRD progression, namely blood pressure and proteinuria, and available evidence suggests that AT2RAs will share the renoprotective properties of ACEI in human CRD.

TL;DR: Patients on hemodialysis are less active than healthy sedentary controls, and this difference is more pronounced among older individuals, and there is an association between the level of physical activity and nutritional status among patients on dialysis.

TL;DR: In patients with chronic renal failure, the presence of high circulating levels of non-1-84 PTH fragments detected by the "intact" assay and the antagonistic effects of 7-84PTH on the biological activity of 1- 84 PTH explain the need of higher levels of 'intact' PTH to prevent adynamic bone disease.

TL;DR: Normalization of hemoglobin does not lead to regression of established concentric LV hypertrophy or LV dilation, and it may, however, prevent the development of LV dilated and it leads to improved quality of life.

TL;DR: At this early phase, the DOPPS has proved to be technically feasible and has revealed basic differences in hemodialysis facilities and patients across the seven participating countries.

TL;DR: It is suggested that in patients with chronic renal disease, dietary protein and energy intakes and serum and anthropometric measures of protein-energy nutritional status progressively decline as the GFR decreases, which may contribute to the decline in many of the nutritional measures.

TL;DR: An association of CRP and fibrinogen with urinary albumin excretion in the micro Albuminuric range in type 2 diabetic and nondiabetic individuals is shown and chronic inflammation emerges as a potential mediator between microalbuminuria and macrovascular disease.

TL;DR: It is suggested that early progressive podocyte damage and macrophage infiltration is associated with hyperlipidemia and type IIb diabetes mellitus, and antedates both the development of glomerulosclerosis and tubulointerstitial damage.

TL;DR: Obese patients are at risk for developing proteinuria and chronic renal failure after unilateral nephrectomy and regular and long-term follow-up is recommended in these patients.

TL;DR: The results support a role for hypoxia in the pathogenesis of fibrosis and provide evidence for novel, direct hypoxic effects on the expression of genes involved in fibrogenesis.

TL;DR: It is suggested that the adenylyl cyclase signaling pathway may have a unique role in determining the rate of cyst enlargement in ADPKD through its actions to stimulate cellular proliferation and transepithelial solute and fluid secretion.

TL;DR: Observations suggest that locally produced MCP-1 may be involved in the development of advanced diabetic nephropathy, especially in the formation of tubulointerstitial lesions possibly through Mphi recruitment and activation.

TL;DR: It is strongly suggested that an antibody to TGF-beta is a promising agent to prevent renal tubular fibrosis and apoptosis in UUO.

TL;DR: An alternative mechanism, chronic hypoxia, is proposed that might better explain certain elements of progressive renal disease, but elements of the hypothesis remain subject to further study.

TL;DR: In vivo and in vitro, tempol significantly reduced the increase in urea, creatinine, gammaGT, AST, NAG, and FENa produced by renal ischemia/reperfusion, suggesting an improvement in both renal function and injury.

TL;DR: Evidence is provided that ROS generated by glucose metabolism may act as integral signaling molecules under HG as in other membrane receptor signaling, and signal transduction pathways linking HG, ROS, PKC, transcription factors, and extracellular matrix (ECM) protein synthesis in mesangial cells have not been fully elucidated.

TL;DR: Demographic and other characteristics that predict risk of hip fracture in the population at large also do so in end-stage renal disease patients, however, no characteristics of ESRD or its treatment that were independently related to hip fracture incidence were identified.

TL;DR: Aldose reductase may both exacerbate and alleviate the production of metabolites that lead to hyperglycemia-induced cellular impairment, with the balance determining the extent of dysfunction.

TL;DR: A stable and reproducible murine model of chronic proteinuria induced by adriamycin (ADR) should be useful in unraveling the pathogenesis of glomerular and interstitial inflammation and fibrosis in chronic proteinuric renal disease.