Showing papers in "Kidney International in 2001"

TL;DR: ORG is distinct from idiopathic FSGS, with a lower incidence of nephrotic syndrome, more indolent course, consistent presence of glomerulomegaly, and milder foot process fusion.

TL;DR: This case-mix adjusted analysis suggests that CVC and AVG are correlated with increased mortality risk when compared with AVF, both overall and by major causes of death.

TL;DR: Lipid reduction may preserve glomerular filtration rate and may decrease proteinuria in patients with renal disease.

TL;DR: This study provides no evidence of a survival benefit of continuous hemodiafiltration compared with IHD, and suggests that a randomized controlled trial of alternative dialysis modalities in ARF is feasible.

TL;DR: FGF-23 proteins containing the ADHR mutations are secreted, and produce polypeptides less sensitive to protease cleavage than wild-type FGF- 23, thereby potentially elevating circulating concentrations of F GF-23 and leading to phosphate wasting in ADHR patients.

TL;DR: In this paper, a better understanding of the mechanisms involved in NF-κB regulation and its modulation may provide new tools to improve the treatment of renal diseases with a better sound pathophysiological approach.

TL;DR: Intrinsic abnormalities of the complement system and of the von Willebrand factor pathway may account for a genetic predisposition to the disease that may play a paramount role in particular in familial and recurrent forms of HUS.

TL;DR: It is suggested that dietary oxalate makes a much greater contribution to urinaryOxalate excretion than previously recognized, that dietary calcium influences the bioavailability of ingested oxalATE, and that the absorption of dietary oxAlate may be an important factor in calcium oxalates stone formation.

TL;DR: This review examines the current in vitro animal and human work underlying the use of rapamycin and comments on the pharmacokinetics and side-effect profile of this promising new agent.

TL;DR: Routine preoperative vascular mapping results in a marked increase in placement of AV fistulas, as well as an improvement in the adequacy of forearm fistulas for dialysis, and double the proportion of patients dialyzing with a fistula in the patient population.

TL;DR: The essentially constant glomerular cell density in nondiabetic and diabetic subjects under different circumstances possibly indicates an underlying propensity for the glomerulus to regulate its architecture to maintain a constant number of cells per volume, no matter the size of the glomersulus or the severity of diabetic nephropathy studied in this set of patients.

TL;DR: The evidence linking CRP with atherosclerosis is outlined and it is proposed that elevated CRP concentrations may be involved in the initiation and progression of accelerated Atherosclerosis in uremia.

TL;DR: Adult blood pressure profile is susceptible to prenatal programming by maternal low-protein diet in the rat and may involve an altered renin-aldosterone axis and a deficit in total nephron number.

TL;DR: There has been an increase in the incidence of PTDM in patients transplanted recently, and that increase can be explained only partially by changes in the recipients' characteristics, postulate that this increase may be due to the introduction of better absorbed CsA formulations that result in higher blood levels and higher cumulative exposure to this diabetogenic drug.

TL;DR: The antiproteinuric effects of ACE inhibitors and lowering blood pressure are greater in patients with a higher baseline urine protein excretion, which is a modifiable risk factor for the progression of non-diabetic renal disease.

TL;DR: This report supports the growing body of data linking glomerulosclerosis directly to a reduction in relative podocyte number [increased glomerular area per podocyte (GAPP)], and raises important questions related to the mechanisms of podocytes loss, strategies for prevention of podocyte depletion, and the prevention of progression of glomersular diseases.

TL;DR: It is suggested that removal of sodium and fluid is a predictor of mortality in PD patients, whereas Kt/V(urea) and TCC are not factors.

TL;DR: The prognosis of diabetic nephropathy has improved during the past decades, predominantly because of effective antihypertensive treatment, and several modifiable variables have been identified as progression promoters.

TL;DR: The traditional definitions of normal 24-hour urine values need to be reassessed, as a substantial proportion of controls would be defined as abnormal, and the association with risk of stone formation may be continuous rather than dichotomous.

TL;DR: IL-10 protects against renal ischemic and cisplatin-induced injury and may act, in part, by inhibiting the maladaptive activation of genes that cause leukocyte activation and adhesion, and induction of iNOS.

TL;DR: To reduce the risk of adverse cardiac events on hemodialysis, the dialysate prescription should be evaluated and modified on an ongoing basis, especially following hospitalization in high-risk patients.

TL;DR: Efforts to prevent vascular access-related infection should focus on increasing placement of arteriovenous fistulas and minimizing insertion of central venous dialysis catheters, and on decreasing administration of specific parenteral antibiotics.

TL;DR: HGF supplementation may be one therapeutic strategy to treat subjects with renal diseases, as it enhances the intrinsic ability of the kidney to regenerate.

TL;DR: The impact of RAS on survival remained robust regardless of the manner of treatment of coronary artery disease [that is, medical, percutaneous transluminal coronary angioplasty (PTCA), or coronary artery bypass graft (CABG)].

TL;DR: Analysis of nephritis in the Nrf2-deficient female mouse may clarify the mechanisms leading to the development of lupus disease and suggest that nrf2 is one of the genes determining susceptibility to autoimmune disease.

TL;DR: The results suggest that macrophages, specific cytokines, and angiogenesis within the neointima and adventitia are likely to contribute to the pathogenesis of VNH in PTFE dialysis grafts.

TL;DR: Studies utilizing OPN gene-deficient mice, antisense-treated or anti-OPN-treated animals have demonstrated that OPN promotes accumulation of macrophages, and may play a role in macrophage-mediated renal injury, but that the effect may be mild and short-lived.

TL;DR: The results indicate that the decreased sialylation and galactosylation of the IgA1 hinge glycopeptides play a crucial role in its glomerular deposition in IgAN.