Showing papers in "Kidney International in 2006"

TL;DR: It is recommended that the term renal osteodystrophy be used exclusively to define alterations in bone morphology associated with CKD, and the term CKD-Mineral and Bone Disorder (CKD-MBD) be used to describe a broader clinical syndrome that develops as a systemic disorder of mineral and bone metabolism due to CKD.

TL;DR: This mini-review attempts to highlight the recent progress in understanding of the cellular and molecular pathways leading to renal fibrosis, and discusses the challenges and opportunities in developing therapeutic strategies.

TL;DR: Associations between high serum parathyroid hormone and increased death risk were masked by case-mix characteristics of MHD patients, and Administration of any dose of paricalcitol was associated with improved survival in time-varying models.

TL;DR: By delineating the events following injury to podocytes, therapies might be developed to reduce the burden of proteinuric renal diseases, and the mechanisms of these events are being elucidated.

TL;DR: This review provides information on the known risk factors for the development of CIN, and describes user-friendly CIN risk score based on the readily available information.

TL;DR: Interleukin-18 is an early, predictive biomarker of AKI after CPB, and that NGAL and IL-18 are increased in tandem afterCPB, suggesting the combination of these two biomarkers may allow for the reliable early diagnosis and prognosis ofAKI at all times after CPBs.

TL;DR: It is concluded that protease inhibitors are essential for preservation, and storage at -80 degrees C with extensive vortexing after thawing maximizes the recovery of urinary exosomes, suggesting minimal protein degradation in the urinary tract/bladder.

TL;DR: Longer TT and higher Kt/V were independently as well as synergistically associated with lower mortality, and a randomized clinical trial of longer dialysis sessions in thrice-weekly HD is warranted.

TL;DR: In this population-based study, the decline in GFR in CKD was slower than in previously studied selected patient groups, and a high mortality pre-empted the development of renal failure in many patients.

TL;DR: A high prevalence globally of microalbuminuria and reduced kidney function was detected in type II diabetic patients without prior known nephropathy, and more aggressive multifactorial treatment aiming at renal and vascular protection are urgently needed.

TL;DR: It is concluded that renin upregulates MC TGF-beta1 through a receptor-mediated mechanism, independent of Ang II generation or action, and may contribute to renal fibrotic disease, particularly when therapeutic Ang II blockade elevates plasma renin.

TL;DR: Observational results suggest that HDF may improve patient survival independently of its higher dialysis dose, and the potential benefits of HDF must be tested by controlled clinical trials before recommendations can be made for clinical practice.

TL;DR: A high rate of renal involvement; a low rate of serious complications; significant associations between renal involvement, genotype, and gender; and a significant association between renal and pulmonary involvement in female patients are confirmed.

TL;DR: Proteomic analysis of urinary exosomes can provide biomarker candidates for the diagnosis of AKI and urinary Fetuin-A might be a predictive biomarker of structural renal injury.

TL;DR: Patients have high risks of ongoing residual renal injury and death after ARF; therefore, periodic evaluation after the initial insult is necessary.

TL;DR: It is demonstrated that MCP-1-mediated macrophage accumulation and activation plays a critical role in the development of STZ-induced mouse diabetic nephropathy.

TL;DR: Cystatin C should not be interpreted as purely a marker of GFR, but may improve GFR estimates in chronic kidney disease patients and other factors, possibly inflammation or immunosuppression therapy, affect cystatinC levels.

TL;DR: The results suggest that greater selectivity in prescribing several classes of psychoactive drugs and more efficient treatment of secondary hyperparathyroidism may help reduce the burden of fractures in HD patients.

TL;DR: The results suggest that increasing the dialysis dose especially for low molecular weight solutes confers a better survival in severely ill patients with ARF.

TL;DR: In this paper, the authors assessed mortality associated with each vitamin D analog and with lack of vitamin D therapy in patients who began hemodialysis at Dialysis Clinic Inc. during the 1999-2004 study period.

TL;DR: The data suggest that free serum levels of p-cresol, a representative of the protein-bound uremic retention solutes, are associated with mortality in HD patients, and may encourage nephrologists to widen their field of interest beyond the scope of small water-soluble ureming solutes and middle molecules.

TL;DR: It appears that tubular reabsorption plays a central role in mediating the effects of albumin on renal function, and the possible implications for the development of renal disease are reviewed.

TL;DR: Careful attention to the usage of beta-blockers and to the maintenance of normal serum potassium values is indicated in HD patients at risk for sudden death.

TL;DR: Reduced renal blood flow (RBF) is considered central to the pathogenesis of septic acute renal failure (ARF) and a marked increase in RBF and with renal vasodilatation was associated with hyperdynamic sepsis and ARF.

TL;DR: In this paper, the authors studied the progression of kidney dysfunction among a community-based cohort of elderly subjects and found that the majority of older adults have no or minimal progression of chronic kidney disease over 2 years.

TL;DR: Kidney donation results in small increases in urinary protein and an initial decrement in GFR is not followed by accelerated losses over a subsequent 15 years, and future studies will provide better estimates, and identify those donors at least risk of long-term morbidity.

TL;DR: It is concluded that high levels of phosphate both at baseline and over follow-up are associated with mortality in incident dialysis patients.

TL;DR: It is found that the majority of elderly subjects have no or minimal progression of kidney disease over 2 years, and strategies aimed at slowing progression of kidneys disease should consider underlying risk factors for progression and the negligible loss of kidney function that occurs in themajority of older adults.

TL;DR: Trends were observed suggesting fosinopril may be associated with a lower risk of CVEs, and trends may have become statistically significant had the sample size been larger, and these findings warrant further study.

TL;DR: It is suggested that a re-evaluation of current treatment recommendations is needed and that future research should focus on mechanisms that distinguish potential tissue specific benefits of selective VDR activators in patients with CKD.