Korean Diabetes Journal 

About: Korean Diabetes Journal is an academic journal. The journal publishes majorly in the area(s): Diabetes mellitus & Type 2 diabetes. It has an ISSN identifier of 1976-9180. Over the lifetime, 278 publications have been published receiving 1698 citations.

The effects of resistance training on muscle and body fat mass and muscle strength in type 2 diabetic women.

Abstract: BACKGROUND Our goal was to investigate the effects of low intensity resistance training on body fat, muscle mass and strength, cardiovascular fitness, and insulin sensitivity in type 2 diabetes. METHODS Twenty-eight overweight women with type 2 diabetes were randomly assigned to a resistance training group (RG, n = 13) or a control group (CG, n = 15). RG performed resistance training using elastic bands, of which strength was equal to 40 to 50% of one repetition maximum (1RM), for three days per week. Each exercise consisted of three sets for 60 minutes. We assessed abdominal fat using computed tomography, muscle mass using dual-energy X-ray absorptiometry, and muscle strength using Keiser's chest and leg press. Insulin sensitivity was measured using the insulin tolerance test, and aerobic capacity was expressed as oxygen uptake at the anaerobic threshold (AT-VO(2)) before and after the 12-week exercise program. RESULTS The age of participants was 56.4 +/- 7.1 years, duration of diabetes was 5.9 +/- 5.5 years, and BMI was 27.4 +/- 2.5 kg/m(2), without significant differences between two groups. During intervention, a greater increase in muscle mass and greater decreases in both total fat mass and abdominal fat were observed in RG compared to those of CG (P = 0.015, P = 0.011, P = 0.010, respectively). Increase in 1RM of upper and lower extremities was observed in the RG (P = 0.004, P = 0.040, respectively), without changes in AT-VO(2) and insulin resistance in either group. CONCLUSION In conclusion, the low intensity resistance training was effective in increasing muscle mass and strength and reducing total fat mass without change of insulin sensitivity in type 2 diabetic patients.

Role of Pyruvate Dehydrogenase Kinase 4 in Regulation of Blood Glucose Levels

Abstract: In the well-fed state a relatively high activity of the pyruvate dehydrogenase complex (PDC) reduces blood glucose levels by directing the carbon of pyruvate into the citric acid cycle. In the fasted state a relatively low activity of the PDC helps maintain blood glucose levels by conserving pyruvate and other three carbon compounds for gluconeogenesis. The relative activities of the pyruvate dehydrogenase kinases (PDKs) and the opposing pyruvate dehydrogenase phosphatases determine the activity of PDC in the fed and fasted states. Up regulation of PDK4 is largely responsible for inactivation of PDC in the fasted state. PDK4 knockout mice have lower fasting blood glucose levels than wild type mice, proving that up regulation of PDK4 is important for normal glucose homeostasis. In type 2 diabetes, up regulation of PDK4 also inactivates PDC, which promotes gluconeogenesis and thereby contributes to the hyperglycemia characteristic of this disease. When fed a high fat diet, wild type mice develop fasting hyperglycemia but PDK4 knockout mice remain euglycemic, proving that up regulation of PDK4 contributes to hyperglycemia in diabetes. These finding suggest PDK4 inhibitors might prove useful in the treatment of type 2 diabetes.

Factors that Affect Medication Adherence in Elderly Patients with Diabetes Mellitus

Abstract: BACKGROUND This study was conducted to evaluate the factors affecting medication adherence in geriatric diabetic patients treated at private clinics and tertiary hospitals We compared the factors affecting medication adherence between these two patient groups METHODS We included 108 diabetic patients older than 65 years treated at one tertiary hospital and 157 patients older than 65 years treated at two private clinics We conducted an interview survey based on the Health Belief Model, and used a questionnaire that included the self-efficacy variable For the medication adherence, Morisky's self-report was used RESULTS The medication adherence based on Morisky's self-report was significantly higher in tertiary hospital patients (611%) compared to private clinic patients (432%) (P < 001) The results showed that drug storage and self-efficacy were factors affecting adherence to medication in tertiary hospital patients (P < 005) The adherence was high in cases of proper drug storage (odds ratio [OR], 5401) and in cases with high self-efficacy (OR, 13114) In private clinic patients, financial level (P < 005), recognition of the seriousness of diabetes complications (P < 005) and self-efficacy (P < 001) were associated with medication adherence The medication adherence was significantly lower in patients whose financial state were moderate than those with lower (OR, 0410), and medication adherence was significantly higher in patients who had higher perceived severity (OR, 2936) and in patients with higher self-efficacy (OR, 4040) CONCLUSION Different strategies should be used to increase medication adherence in geriatric diabetic patients, depending on institutions whether they are treated

The Relationship of Adiponectin/Leptin Ratio with Homeostasis Model Assessment Insulin Resistance Index and Metabolic Syndrome in Apparently Healthy Korean Male Adults

Abstract: Background We investigated the relationships of adiponectin/leptin (A/L) ratio with cardiovascular risk factors, insulin resistance index, and metabolic syndrome (MS) in apparently healthy Korean male adults.

A Nationwide Survey about the Current Status of Glycemic Control and Complications in Diabetic Patients in 2006: The Committee of the Korean Diabetes Association on the Epidemiology of Diabetes Mellitus

Abstract: Background: The Committee of the Korean Diabetes Association on the Epidemiology of Diabetes Mellitus performed a nationwide survey about the current status of glycemic control and diabetic complications in 2006. Methods: The current study included 5,652 diabetic patients recruited from the rosters of endocrinology clinics of 13 tertiary hospitals in Korea. Age, gender, height, weight, waist circumference and blood pressure were investigated by standard method. Fasting and postprandial 2 hour glucose, glycosylated hemoglobin (HbA1c), lipid profiles, fasting insulin and c-peptide levels were measured. Microvascular (microalbuminuria, retinopathy and neuropathy) and macrovascular (coronary artery disease [CAD], cerebrovascular disease [CVD] and peripheral artery disease [PAD]) complications were reviewed in their medical records. Results: Mean age of total subjects was 58.7 ( 11.6) years and duration of diabetes was 8.8 (050) years. Mean fasting and postprandial 2 hour glucose levels were 145.9 55.0 and 208.0 84.4 mg/dL, respectively. Their mean HbA1c was 7.9 1.9%: the percentage of patients within target goal of glycemic control (