Letters in Drug Design & Discovery 

About: Letters in Drug Design & Discovery is an academic journal published by Bentham Science Publishers. The journal publishes majorly in the area(s): Chemistry & Docking (animal). It has an ISSN identifier of 1570-1808. Over the lifetime, 2056 publications have been published receiving 12118 citations. The journal is also known as: Letters in drug design and discovery.

Recent Developments in Natural and Synthetic Drug Research for Alzheimers Disease

Abstract: Alzheimer's Disease (AD) is a progressive and degenerative neurological disorder characterized by loss of cognition and memory. However, the pathogenesis of AD is still not clearly known. Current research in drug discovery for treatment of AD involves various targets, being only symptomatic, with the main therapeutic strategies based on "cholinergic hypothesis" and "amyloid cascade hypothesis". During the last decade, inhibitors of acetylcholinesterase (AChE) such as tacrine (Cognex ® ), donepezil (Aricept ® ), rivastigmine (Exelon ® ), and galanthamine (Reminyl ® ) have been launched. More recently, memantine (Ebixa ® ) has been emerged on the market as an N-methyl-D-aspartate (NMDA) receptor antagonist, which has been approved to be effective in the treatment of moderate to severe type of AD. In this review, we will focus on recent status of drug molecules for treatment of AD, currently either that in clinical practice, or still in clinical trials.

Szeged Index - Applications for Drug Modeling&#

Abstract: In this review we describe various applications of Szeged (Sz) index for modeling physicochemical properties as well as physiological activities of organic compounds acting as drugs or possess pharmacological activity. © 2005 Bentham Science Publishers Ltd.