Showing papers in "Life Sciences in 1969"

TL;DR: It is concluded that the 2 hour PCA activity of mouse antiserum in mice is due to 7Syl antibody whereas the 72 hourPCA activity in mice and the PCAActivity in rats are due to a heat labile reagin like antibody.

TL;DR: This paw edema responded to anti-inflammatory drugs to decrease this inflammatory response and was induced in the mouse and found to follow a time pattern similar to that seen in the rat.

TL;DR: Food intake of rats fed diets containing a large amount of indispensable amino acids low in the growth limiting one was reduced 40–50% below that of the control in normal or cannulated rats infused with saline, providing evidence for a food intake regulatory function of some portion of the brain which is sensitive to the concentration of the growth limitations amino acid in blood.

TL;DR: Species differences in the metabolism of ethylmorphine parallel differences in NADPH-cytochrome c reductase, cytochrome P-450 content or the type I spectral change caused by ethyl morphine as mentioned in this paper.

TL;DR: A daily rhythm for two drug metabolizing enzymes in liver, hexobarbital oxidase and p-nitroanisole o-demethylase, and its relation to environmental lighting is described.

TL;DR: In this article, α-Chlorohydrin produced reversible sterility in male rats and the minimally effective oral dose was 5 mg/kg/day × 14 which was 5 times lower than the anti-spermatogenic dose.

TL;DR: Noradrenaline, dopamine and 5-hydroxytryptamine were determined chemically and histochemically in the brains of rats given lithium with the food for three weeks, indicating that prolonged administration of small lithium doses leads to a lowering of the activity in 5- Hydroxytryptamines neurons or an inhibition of the impulse-stimulated release of 5-Hydroxyt Kryptamine at the nerve terminals.

TL;DR: It is proposed that these cells are involved at pulmonary level in the production of both amines and the kinin-generating system, interfering with various pulmonary areas such as the circulatory adaptation (or failure) of the newborn at birth and pulmonary oncology (carcinoid and oat cell tumors).

TL;DR: It is suggested that part of the mechanism of action of hallucinogenic drugs may be to inhibit the release of NA from the neurone, hence allowing its catabolism by MAO.

TL;DR: Results support the theory that LSD may owe at least part of its hallucinogenic activity to an ability to alter the capacity of the tissues to bind 5-HT and strongly supports the implication of this action in hallucinogenesis.

TL;DR: It is suggested that the ester group in the genin has an important role in the manifestation of the antisweet activity of gymnemic acid A1.

TL;DR: Results of an attempt to deprive subjects of EEG stages 3 and 4,5 referred to as slow wave sleep (SWS), to test the effect of this deprivation on release of HGH in sleep suggest that deprivation of SWS results in diminished and delayed secretion of H GH in sleep.

TL;DR: The hypothesis that p-ClPhe, a specific depletor of brain serotonin, reduces emotionality rather than increases learning ability is supported.

TL;DR: The Bohr effect expressed as δ log P 50 δ pH has been measured in dialysed haemoglobin solutions with and without added 2,3 DPG in the absende or in the presence of CO 2.

TL;DR: An increased catabolism of exogenous norepinephrine was observed in the brains of rats subjected either to total sleep deprivation or to close confinement on flower pots without abolition of paradoxical sleep, suggesting that stress reactions were occuring.