Showing papers in "Life Sciences in 1970"

TL;DR: Clonidine increased the flexor reflex of spinal rats also after depletion of all known noradrenaline stores, indicating a stimulation of also central noradRenaline receptors.

TL;DR: Human fetal liver microsomes were shown to contain the components of the NADPH- and NADH-linked electron transport systems, but the system was capable of hydroxylating testosterone and laurate, but unable to oxidize exogenous substrates such as 3, 4-benzpyrene and aminopyrine.

TL;DR: A progressive hereditary myopathy of mice caused by a second allele, dy 2J, at the dy -locus is described, which is milder than the original muscular dystrophy, and both afflicted males and females have bred.

TL;DR: In this article, the effect of graded doses of prostaglandin E2 (PGE2) on release of noradrenaline and on smooth muscle contraction in response to nerve stimulation in cat spleen was studied.

TL;DR: The results suggest that Li inhibits vasopressin-induced antidiuresis at the level of adenyl cyclase, suggesting that NaCl may modulate the kidney response to vasoppressin.

TL;DR: Experimental data with larger doses of alcohol to alcoholics suggest that 4-methylpyrazole acts as a competitive LADH-inhibitor and a dose-response relationship between degree of inhibition and dose of 4- methyl pyrazole is indicated.

TL;DR: The AFG cells could interfere with various pulmonary areas, such as bronchial smooth muscle tone, pulmonary vasomotion, the circulatory adaptation (or failure) of the newborn at birth and pulmonary oncology (carcinoid and oat cell tumors).

TL;DR: Ingestion of Ni++ and Zn++ by patients with thiol-induced hypogeusia lowered taste thresholds to normal and there was a proportionate decrease in detection and recognition thresholds for each of four taste qualities.

TL;DR: Pretreatment of rats with lithium chloride increased the rate of brain serotonin turnover and was accentuated by electrical stimulation of serotonincontaining neuronal perikarya in the dorsal raphe nucleus.

TL;DR: Electroshock produces a 175% increase in the brain free fatty acid content in vivo and it is suggested that an excitable membrane phospholipase A activation may be responsible for the effect.

TL;DR: The results suggest that ethanol causes the qualitative and quantitative changes of smooth endoplasmic reticulum and secondarily the change of drug metabolizing enzyme activities.

TL;DR: In the hydrated goat a central effect of angiotensin enhanced the natriuretic response to intraventricular infusions of hypertonic NaCl, suggesting that both an expanded fluid volume and an elevated intracellular Na + concentration may be needed to obtain optimal activation of a brain mechanism which stimulates renal sodium excretion.

TL;DR: The rate at which 14 C tyrosine is incorporated into catecholamines is diminished after rats have been treated with thyroxine for ten days, and discharge as well as synthesis is probably decreased.

TL;DR: A combined gas chromatographic-mass spectometric method for separation identification and estimation of prostaglandins in amounts as low as 10 ngm can be applied successfully to prostag landins in extract of biological material.

TL;DR: It was suggested that the tryptophols or the corresponding aldehydes may play a role in physiological sleep mechanisms, probably due to difficulty of transport across the blood-brain barrier.

TL;DR: An increased P-450 level is evident 24 hours after topical treatment of another resistant strain, Orlando-DDT, with dieldrin; ethyl isocyanide reveals spectral differences between the normal and induced cytochrome P- 450 with females of this strain.

TL;DR: Recordings of steady state tympanic membrane and rectal temperature were made on three subjects in ambient environments of 10, 16, 22, 28, 34, 39, and 44 C and temperature was related to ambient temperature and was consistently lower than Rectal temperature in the cold and higher than rectalTemperature in the heat.

TL;DR: South American freshwater stingrays, which lack the high urea content characteristics of all marine and euryhaline elasmobranchs, fail to build up their urea concentration appreciably even when exposed to a saline environment gradually increased to a concentration approaching that of full strength sea water over a period of as much as six days.

TL;DR: Differences in various types of tumors correlated with histological diagnosis, may perhaps help to determine the degrees of malignancy of intracranial tumors.

TL;DR: Polymorphonuclear leucocytes treated in vitro with phospholipase C exhibit a marked increase of the respiration, which is insensitive to KCN, and of the catabolism of glucose through the hexose monophosphate shunt, similar to those occuring in phagocytosing polymorphonuclearLeucocytes.