Showing papers in "Life Sciences in 1971"

TL;DR: Increase of EEG alpha activity, sleep, imagery, and a feeling of well-being and elation were found and a decrease in paroxistic grapho-elements of the epileptic patients was noticed.

TL;DR: It is demonstrated that MIF greatly potentiates the behavioral effects of DOPA in mice, independent of MSH since MIF was found to potentiate DOPA effects in hypophysectomized mice.

TL;DR: It is suggested that papaverine relaxes smooth muscle by causing an accumulation of cyclic 3′,5′-AMP (1, 2, 3, 4) which led to the most potent inhibitor of PDE among numerous smooth muscle relaxants, including theophylline.

TL;DR: Using a quantitative bioassay technique, a cyclic variation in pineal melatonin content was monitored in laboratory rats and two species of birds and the oscillation was found to bear a consistent phase relationship to that of cyclic changes in environmental illumination.

TL;DR: It is suggested that a cholinergic hypofunction in a mechanism regulating striatal motor activity may exist in Huntington's chorea.

TL;DR: It is suggested that 6-hydroxydopa has the ability to cause selective destruction and/or marked impairment of noradrenergic terminals, which in the brainstem, are capable of regeneration or replenishment of the neurotransmitter.

TL;DR: It was concluded that both activity and emotionality are associated with an activation of dopamine neurones, and an increase in activity in the absence of stress will accelerate the metabolism of dopamine.

TL;DR: Piperonyl butoxide produces a typical type I substrate difference spectrum with cytochrome P-450 in the oxidized state, however, the inclusion of NADPH with piperonyL butoxide effects a spectrum similar to that of ethyl isocyanide.

TL;DR: These studies have confirmed the findings of Agurell et al, that in rats THC is excreted almost completely in feces as more polar metabolites, and evidence is presented which shows that THC disappears from the tissues of rats in a biphasic fashion.

TL;DR: It is concluded that some aminoacids can exert a ouabain-like effect in guinea-pig and rat hearts, and that effects of taurine and ouABain are additive.

TL;DR: The enzymatic hydroxylation of 3,4-benzpyrene by lung was increased 34% and 186% in rats exposed to cigarette smoke for 2 or 4 hours, respectively, whereas induction of BP-hydroxylase in lung by cigarette smoke was completely blocked by actinomycin D or puromycin.

TL;DR: In spite of weak uptake inhibition, iprindole potentiated the awakening effect of 1-dopa in reserpinized mice and the inhibition of the neuronal uptake of the biogenic amines is discussed.

TL;DR: Incorporation of amino acid into protein was reduced in both brain and liver ribosomes 1.5–3 hours after a single administration of ethanol, suggesting ribosomal protein synthesis is rather insensitive to the in vitro addition ofanol, as compared with the in vivo administration.

TL;DR: A convenient, rapid technique for the chronic intraventricular cannulation of small animals, the main advantage of the technique is that it enables the investigator to study the effects of drugs on the brains of unanesthetized animals.

TL;DR: In this article, the effects of Δ1-Tetrahydrocannabinol (Δ1-THC) on 5-HT metabolism in the rat brain were investigated.

TL;DR: This study describes the daily rhythmic changes that occur in the concentrations of 12 amino acids in rat plasma, useful in assessing the significance of changes in plasma amino acid levels observed in rats several hours after particular experimental manipulations.

TL;DR: In this article, the effect of freshwater and seawater adaptations on the specific activity of microsomal Na+  K+ ǫ ATPase in gill filaments and kidneys of two euryhaline marine teleosts was reported.

TL;DR: It appears that whatever the cues were to which the rats differentially responded, the effect is mediated by nicotine's action on the central nervous system.

TL;DR: It was confirmed that a circadian rhythm of spontaneous motor activity, and accordingly of the sleep-and-wakefulness pattern is formed gradually about 3 weeks after birth, and it was suggested that the maturation of circadian Rhythm of brain norepinephrine and serotonin contents is closely related with that of spontaneous activity and theSleep- and- wakefulness mechanism.

TL;DR: Biochemical analyses of autopsy brain samples of a patient with Parkinson's disease treated with L-DOPA showed clearly increased concentrations of dopamine and homovanilic acid in the extrapyramidal brain regions as well as in the hypothalamus, thalamus, cerebral and cerebellar cortex as compared to the normal control and Parkinsonian brain samples.

TL;DR: Mitochondrial (oligomycin-sensitive) Mg 2+ ATPase from cockroach muscle is shown to have a very high sensitivity to DDT when compared to fish brain preparations and to inhibition of the same enzyme system by dicofol.

TL;DR: Both mercurials produced the following manifestations of toxicity in the maternal system: weight loss, kidney lesions, diarrhea, slight tremor and somnolence.

TL;DR: The results are compatible with the suggestion that low intracellular [Ca ++ ] is a necessary condition for active NaK-transport in red cells.

TL;DR: The dependence on time of the 59 Fe content in the total particle-free fraction of iron-deficient rats during absorption was determined by the iron-binding protein 2 while in mucosal cells of normal rats, protein 1 determined the time course.

TL;DR: The addition of sodium succinate to whole semen did not significantly increase the oxygen consumption of the sperm while the respiratory activity of washed spermatozoa was increased 2 to 3 times by the succinate.

TL;DR: In Avena coleoptile sections treated with indole acetic acid there is an increase in the synthesis of cyclic 3′, 5′-adenosine monophosphate as compared to untreated sections, seen within 30 minutes.

TL;DR: Removal of ovary, thyroid or adrenal partially overcame the effect of estradiol in decreasing liver COMT in normal but not in hypophysectomized rats.