Showing papers in "Life Sciences in 1973"

TL;DR: A personal and admittedly incomplete view of the latter aspect of the role of zinc in the stability of macromolecules, particularly the components of various biological membranes is presented.

TL;DR: The results indicate that brain tryptophan and serotonin turnover are controlled by free serum Try and that free serum tryPTophan levels are independent from total serum tryaptophan concentrations.

TL;DR: Neurons in the rat brain identified as dopaminergic were found to be remarkably homogeneous with respect to their firing pattern, and responses to drugs and other substances administered systemically, or applied iontophoretically.

TL;DR: This chapter describes the neurotransmitter uptake as a tool in identifying neurotransmitter-specific pathways and there is abundant evidence that the sites of NE uptake in brain, under high-affinity conditions are localized to NE-containing neurons.

TL;DR: Two new adrenergic beta-receptor antagonists, H 93/26 and H 87/07, were compared with propranolol, alprenolol and practolol in some in vivo studies in the cat and guinea pig and inhibited the studied responses to isoprenaline at about the same doses.

TL;DR: Investigating effect of impulse flow on the release and synthesis of dopamine (DA) in the rat striatum revealed that GHB or GBL administered intravenously or intraperitoneally in doses of 100–200 mg/kg routinely, decrease the firing of units localized to the DA containing cells present in the zona compacta of the substantia nigra.

TL;DR: Brain tryptophan increases significantly within two hr of the time that rats begin to consume a diet containing carbohydrate and fat, but fails to rise if the diet also contains 18–24% protein.

TL;DR: This article showed that chronic ingestion of lead from birth can produce a significant behavior disorder in mice, including hyperactivity and retardation in the offspring of mice with mild exposure to lead during parturition.

TL;DR: It is suggested that the bulk of the low affinity uptake is due to non-synaptosomal structures and is destroyed during the preparation of 0.1 × 0.

TL;DR: The results indicate that all three cannabinoids are effective anticonvulsant activity of delta-9-tetrahydrocannabinol, cannabidiol and cannabinol, in a maximal electroshock test in mice.

TL;DR: The projections of the nucleus locus coeruleus were reconstructed from serial section autoradiographic analysis and pathways could be traced from their origin in the LC to their terminal regions, including the limbic cortex, hippocampus, neocortex, amygdala, cerebellar cortex, and various brainstem nuclei.

TL;DR: It is suggested that physiological changes in plasma non-esterified fatty acids levels can affect the availability of free tryptophan to the tissues by altering the binding properties of plasma albumin.

TL;DR: The acute administration of ethanol, like other CNS depressing drugs, lowers body temperatures in mice and Benzyl alcohol which is widely used as preservative in parenteral solutions also has a behaviorally sedating and hypothermic effect.

TL;DR: It appears that these ubiquitous amines play important roles in the physiological regulation of growth, and many of the definitive roles are yet to be elucidated, and these areas offer promise to biochemists.

TL;DR: The data indicate that plasma DBH in human is partially genetically controlled, and Monozygotic twins showed higher concordance for DBH activity than dizygotic twins.

TL;DR: Bu arastirma gebelerin onemli bir bolumunun bulanti-kusma, sik idrara cikma, vajinal kanama, memelerde hassasiyet, konstipasyon, gaz, hemoroid, sirt agrisi, bacak kramplari gibi sorunlari yasadiklari sonucunu aciga cikarmistir.

TL;DR: Incubation of washed human spermatozoa in the presence of 6 mM concentrations of EDTA, histidine and cysteine induces a release of about 75% of the zinc bound to the cells, which is related to the regulation of energy metabolism and probably to sperm capacitation.

TL;DR: An automated assay based on Autoanalyser equipment for the fluorimetric determination of histamine in biological fluids is described and a major advantage of the technique lies in its reliability and the consequent saving in time and labour in the performance of routine histamine assays.

TL;DR: Superphysiologic levels of 25-hydroxyvitamin D 3 may simulate lα,25-dihydroxyv vitamin D 3 and act directly on isolated target organs and the biologic potency observed for low doses of lα-hydroxylation of the l α-derivative is probably the result of25-hidroxylated of theLα-Derivative to form l α,25,dihYDroxyv Vitamin D 3.

TL;DR: It is suggested that this imbalance in the ratio of these two cyclic nucleo- tides may have pathophysiological relevance to the initiation and/or the maintenance of the psoriasis lesion.

TL;DR: Prilocaine chloride was shown to inhibit the basal as well as the stimulated lipolysis by human subcutaneous and omental adipose tissue and abolish the antilipolytic effect of insulin on these processes.

TL;DR: The results suggest that ongoing DA synthesis is necessary for d-AMP to exert its effect, and that DA receptors may be involved in d-AMPs ability to depress DA neurons.

TL;DR: The results suggest that ethanol oxidation inhibits β-oxidation of fatty acids and that this primary effect leads to accumulation of liver triglycerides by increased esterification of plasma free fatty acids.

TL;DR: Administration to weanling mice of a diet in which the digestible carbon fraction averaged 80 atom % carbon-13 led to an average tissue content of 60 atom %carbon-13 with little change in overall enrichment between 127 and 234 days of feeding.

TL;DR: Microsomal fractions of human fetal adrenal gland homogenates were found to contain large quantities of a carbon monoxide binding pigment which exhibited an absorption maximum between 446 and 448 nm.

TL;DR: It is concluded that the described technique can successfully detect the opiate narcotic receptors in the central nervous system without the usual method of displacement.

TL;DR: This compound (JH III), which occurs in a sphingid moth Manduca sexta, is the first juvenile hormone identified in an insect order other than the Lepidoptera.

TL;DR: Levamisole, a broad-spectrum anthelmintic, increased the delayed hypersensitivity skin reaction to tuberculin and to DNCB in about one third of the patients.

TL;DR: Food deprivation did not change hypothalamic norepinephrine levels but increased dopamine levels, and a role for newly synthesized catecholamines in the regulation of this behavior is suggested.

TL;DR: The cationic requirements for DA-uptake in striatal tissue and its responses to several inhibition of ionic transport, do not appear to be greatly different from those reported for NE with synaptosomes prepared from whole brain.