Showing papers in "Life Sciences in 1977"

TL;DR: Modification of the original single isotope radioenzymatic assay of Passon and Peuler permits the direct and simultaneous analysis of norepinephrine, epinephrine and dopamine in plasma samples of 50 μl or less.

TL;DR: A division of adrenergic receptors into alpha and beta types could conceivably lead to the development of powerful agents even more selective for inhibition of renin release, control of blood pressure by a central site of action, reduction of fever, and possible other scientific or therapeutic applications.

TL;DR: It is suggested that endogenous morphinomimetic substances may participate in regulating secretion of anterior pituitary hormones through regulating the response to naloxone and morphine.

TL;DR: The use of liposomes as drug carrying vehicles, introduction of smaller doses, increased permeability, reduced toxicological and allergic effects and altered immunological responses are the advantages of the method.

TL;DR: Chlorophenoxyisobutyrate (CPIB) and salicylic acid, the metabolites of clofibrate and aspirin, were quantitated by gas chromatography-mass spectrometry in the effluent of a sewage disposal plant in Kansas City, Missouri.

TL;DR: The recently discovered specificbinding sites for benzodiazepines in the central nervous system have been characterized further and equilibrium between the specific binding sites and 3H-diazepam is reached within 15 min.

TL;DR: It is indicated that long-term haloperidol treatment produces rather selective increases in dopamine/neuroleptic receptors, without much change in 4 other types of receptors.

TL;DR: Immunocytofluorescence techniques with well characterized anti-sera to α- endorphin and β-endorphin show presence of these two peptides in all cellular elements of the Pars intermedia of the rat hypophysis and in discrete cells of the pars distalis at the complete exclusion of the neurohypophysis.

TL;DR: For instance, the authors showed that peptides derived from the anterior pituitary (ACTH, growth hormone), the intermediate lobe (α-MSH), and the posterior lobe (vasopressin) of the pituitar cortex have been shown to modulate conditioned behavior.

TL;DR: It is suggested that a progressive loss of dopaminergic receptors in the caudate nucleus may contribute to the decreased response of Parkinsonian patients to L-dopa and dopamine agonist therapy.

TL;DR: None of the drugs demonstrated a direct action on anterior pituitary tissue growth hormone or prolactin release in vitro and naloxone hydrochloride blocked the hormone-stimulatory effect of the opioid receptor agonists.

TL;DR: Using the abdominal constriction response as the criterion for analgesia, mice tested immediately after a period of footshock showed a significant analgesic response compared with non-footshocked controls, concluding that footshock induced analgesia in the mouse is due to the release of endogenous opioid peptides.

TL;DR: Highly purified cholinesterase from human plasma when diluted to the same benzoylcholine hydrolyzing activity as human plasma, shows the same rate of cocaine hydrolysis ashuman plasma.

TL;DR: The localization of met-enkephalin was carried out in the presence of excess leu-encephalin and yet could be blocked with equal amounts of meet-enkphalin.

TL;DR: It is concluded that cytochrome P-450 is the site of bioactivation of these three compounds rather than NADPH cy tochrome c reductase and that CCl4 bioactivation proceeds by cyto Chrome P- 450 dependent reductive pathways, while CHCl3 activation proceeds by CytochromeP-450 dependent oxidative pathways.

TL;DR: Bombesin induced hyperglycemia may be mediated via adrenomedullary-catecholamine induced changes in insulin and glucagon secretion resulting in enhanced hepatic glucose output.

TL;DR: The view that vasopressin is participating in the regulation of a variety of physiological processes by modulating neurotransmission in specific brain nuclei is supported by the results.

TL;DR: No definitive evidence exists that compounds other than the classical Pgs are active in immune cell inhibition, but the recent indications that Pgs may mediate their effects through the cyclic endoperoxides and non-prostanoate metabolites may prove to be an important challenge to the many proposed roles of Pgs.

TL;DR: These findings further support the hypothesis that intracerebral injections of kainic acid cause degeneration of neurons with cell bodies near the injection site while sparing axons passing through or terminating in the region.

TL;DR: Investigation of the occurrence of numerous nerves containing the vasoactive intestinal polypeptide (VIP) in the male genital tract shows that the nerves occur in association with arteries and smooth musculature of the organs.

TL;DR: It is indicated that disruption of tissue modifies the content of opioid peptides in brain by being readily hydrolized by brain homogenates with consequent appearance of α-endorphin.

TL;DR: Liposomes containing 111In-labelled bleomycin were injected intravenously into normal and tumour-bearing rodents and the fate of radioactivity followed, enabling accurate estimations of tissue participation which was secondary to that of the liver and spleen.

TL;DR: Melatonin excretion data in man appear to be inconsistent with previous studies in rats showing rapid light-induced suppression of the nocturnal rise in pineal melatonin synthesis.

TL;DR: It is shown that the first step in the breakdown of met-enkephalin in both plasma and brain tissue is cleavage of the Tyr-Gly amide bond, which offers an explanation for the low activity of meet-enkphalin after intraventricular or intravenous administration.

TL;DR: In two experiments, behavior induced by apomorphine was potentiated during the initial post-injection period following a course of repeated, daily administrations of d-amphetamine or cocaine, suggesting the development of supersensitive dopaminergic post-synaptic mechanisms.

TL;DR: It is indicated that activation of either central dopaminergic or noradrenergic receptors can result in positive reinforcing effects.

TL;DR: It is suggested that caffeine is a moderately poor substrate for the cytochromes P-450 present in control and phenobarbital-pretreated rats, but a particularly good substrates for the form(s) induced by 3-methylcholanthrene.