Showing papers in "Life Sciences in 1979"

TL;DR: Data from studies of the function of the nucleus locus coereleus in non-human primates are presented in the context of recent anatomical, physiological, pharmacological, and animal behavioral experiments, suggesting implications for the treatment of anxiety, drug addictions, pain, and psychosomatic diseases.

TL;DR: It is emphasized that antagonism by naloxene is a necessary but not sufficient criterion for invoking the mediation of a response by an endogenous opiate, and additional lines of evidence which serve to strengthen the conclusion that endogenous opiates mediate a process will be considered.

TL;DR: High performance liquid chromatography with electrochemical detection has been compared to a radioenzymatic method for the determination of plasma catecholamines and showed an excellent agreement between the methods.

TL;DR: Preliminary observations indicate that the EOP may increase serotonin and decrease dopamine metabolism in the hypothalamus, which could account for practically all of their effects on pituitary hormone secretion.

TL;DR: Various methods for the determination of pA 2, and the accuracy and precision of these methods, are presented, with particular attention being given to narcotic analgesics and their antagonists.

TL;DR: The ability of capsaicin to release SP supports the hypothesis that SP is involved in pain transmission and in neurogenic plasma extravasation.

TL;DR: The findings suggest that methods which measure the dynamic processes of norepinephrine release and removal quantify sympathetic nervous activity better than steady state plasma norpinephrine measurements alone.

TL;DR: 1-isoamyl-3-isobutylxanthine might prove useful as an inhibitor of this enzyme because of its very low activity as an adenosine-antagonist.

TL;DR: Electroacupuncture analgesia induced by low frequency stimulation may be mediated by endorphins while high frequency stimulation is not endorphinergic but may be partly due to serotonin.

TL;DR: The correspondence of separate binding sites with distinctive patterns of physiological responses indicates the existence of two discrete types of postsynaptic α-receptors, which are proposed to designate sites labeled by WB-4101 as α-1 receptors and those labeled by 3H-clonidine,3H-norepinephrine and 3h-epinephrine asα-2 receptors.

TL;DR: One of the metabolites of TRH histidyl-proline diketopiperazone, appears to have a number of extrahypothalamic actions and this suggests the need for further exploration of the affects of this compound both on the central nervous system and the gastrointestinal tract.

TL;DR: The concept that the multiple actions of peptides can be independent of each other is supported by evidence that even though peripheral administration of the brain opiates is essentially ineffective in producing analgesia, other actions of these peptide can be observed after administration by this route.

TL;DR: It is demonstrated for the first time that a low concentration of nicotine is effective in releasing DA by acting on presynaptic nicotinic receptors located on terminals of the nigro-striatal dopaminergic neurons.

TL;DR: The use of [ 3 H] dihydroergocryptine displacement curves generated with selective alpha receptor antagonists coupled with subsequent computer modeling provides a precise and powerful method for quantifying the alpha receptor population of a tissue.

TL;DR: Evidence is presented that rats given diet mixtures containing various proportions of carbohydrates have the ability to regulate their carbohydrate intakes, and that this ability is independent of whether or not the carbohydrate consumed has a sweet taste.

TL;DR: It is suggested that vanadium can directly influence glucose metabolism and may play a role in its regulation in vitro.

TL;DR: Two major silver staining proteins were found which were identified as (molecular weight × 10 −3 /pI) proteins C23 and B23 which are the major acidic proteins in Novikoff hepatoma nucleoli.

TL;DR: Results are supportive of the hypothesis that endogenous opioid peptides modulate the release of dopamine by tuberoinfundibular neurons into hypophysial portal blood.

TL;DR: This study illustrates the relative importance of the different pharmacological properties of these compounds, provides a tool for further meaningful pharmacological and biochemical research in this area, and discusses the therapeutic potential of these drugs.

TL;DR: The results demonstrate release of VIP from the hypothalamic-neurohypophyseal complex into the portal circulation, and establish a mechanism for direct influence of the peptide on pituitary function.

TL;DR: It would appear that the toxic effects of methamphetamine reported previously cannot be attributed to a generalized destruction of the neostriatum but are demonstrable only in selected biogenic amine nerve terminals.

TL;DR: These experiments represent the first direct demonstration of bioactivation of a proteratogen in vitro and show that cyclophosphamide concentrations as high as 250 micrograms per milliliter were innocuous when either the microsomal material or cofactors were omitted from the medium.

TL;DR: It is suggested that chronic treatment with antidepressants induces persistent subsensitivity in presynaptic dopamine receptors in rats, and the relevance of the findings in the therapeutic effect of these drugs is discussed.

TL;DR: Data are presented which show that the xanthine stimulants caffeine, theophylline, and theobromine as well as the central nervous system convulsant pentylenetetrazol all competitively inhibit [ 3 H] diazepam binding.

TL;DR: It is evident that AChE histochemistry continues to be a valuable neurobiological tool, particularly in characterizing neurons that may be cholinergic, and also in identifying those neurons that cannot beCholinergic.

TL;DR: It is suggested that centrally acting pituitary hormones may have a requisite function in normal and adaptive pain control in mammals and be reversed by adrenocorticotropin pretreatment.

TL;DR: Different asymmetries appear to be organized along different dimensions in both the rat and human brains, with evidence of functional brain asymmetry.

TL;DR: The possibility that endorphins may have a modulating effect on feeding activity is suggested, as the effect of acute and chronic administration of naloxone on food acquisition and weight gain in rats was studied.

TL;DR: Enkephalinase A activity can be completely resolved by DEAE column chromatography from angiotensin converting enzyme activity, demonstrating that they are distinct enzymes.

TL;DR: The loss in β-adrenergic receptor binding does not correlate in a temporal fashion with the reported decrease in norepinephrine-stimulated cyclic AMP accumulation in the cerebellum which occurs as early as 12 months of age.