Showing papers in "Life Sciences in 1980"

TL;DR: The liposomal encapsulation favourably altered the drug dipposition; the concentration of the drug decreased at the site of its adverse effects and increased at the sites where its activity is desired.

TL;DR: The data suggest that the blockade of opiate receptors by NLTRX in rhesus monkeys apparently decreases the reinforcing effects of EtOH measured with IVSA techniques.

TL;DR: It is suggested that the interval between electrical, drug, or psychological stimuli is important in determining subsequent responsivity and may shed light on similarities and differences in mechanisms underlying tolerance and sensitization.

TL;DR: A number of similarities and minor differences between the monoaminergic and peptidergic control of appetite and the central control of analgesia and temperature regulation suggests the possibility that there may be a degree of nonspecificity in the control of these closely related life-sustaining processes.

TL;DR: Trains of low frequency stimulation (LFS) were administered to the Schaffer collateral-commissural projections to the regio superior of the rat hippocampus before and after the induction of long-term potentiation (LTP).

TL;DR: It is suggested that alpha1 receptors mediate those metabolic effects of alpha catecholamines which involve phosphatidylinositol turnover and the release of bound intracellular Ca2+ as well as the entry of extracellular Ca1+ in rats, hamster adipocytes and blowfly salivary glands.

TL;DR: It is suggested that morphine and bremazocine interact with different subpopulations of opiate receptors, and the actions of the antagonists naloxone and Mr 2266 suggest a preference for opiate kappa-receptors.

TL;DR: The mechanisms underlying this complex response may be mediated by descending 5-HT systems that result in motor excitation at the spinal cord level, in contrast to rostral projections to forebrain that may mediate many behaviorally inhibitory responses.

TL;DR: Platelet MAO activity was significantly higher in patients with dementia of Alzheimer type compared to controls and this could be explained by differences in age of onset of dementia and that the disease process does not develop homogeneously in different brains.

TL;DR: The binding characteristics of [3H] imipramine to platelets is similar to that in rat and human brain and may thus serve as a useful model in elucidating the pharmacological and physiological significance of these binding sites.

TL;DR: In vitro studies suggest that sodium butyrate may be useful in the management of neoplasms by causing selective cell death, and/or cell differentiation and by increasing the cell killing effect in conjuction with currently used tumor therapeutic agents.

TL;DR: Dose response uterotrophic and antiuterotrophic activity of antiestrogens was examined in immature rats, immature mice and adult ovariectomized mice and results depict significant agonist and antagonist advantages of LY117018 over tamoxifen and trioxifene.

TL;DR: In experiments carried out with selective agonists ICI 118, 551 distinguished clearly between tissues with a mixed s-adrenoceptor population (different pA2 values) and those with a homogeneous population (single pA 2 value).

TL;DR: The findings in young mice support a similar function for amino acids, taurine in particular, in mammalian brain and suggest that the phenomenon may be causally related to the cerebral edema that develops during overly rapid rehydration of infants and children with chronic hypernatremic dehydration.

TL;DR: This assay methodology may be useful in demonstrating individual variations in the ability to sulfate endogenous catechols inStanding subjects, changes in the free levels and in the ratio of free to total levels of DA and DOPA were less than those noted for NE and E.

TL;DR: The findings suggest that narcotic antagonists should be considered as possible anorexics selective for stress-induced eating, and that endogenous opiates may prove to be another significant factor involved in the control of food intake.

TL;DR: Results are consistent with the existence of a D2-like DA receptor on striatal glutamatergic terminals capable of modulating the transmitter release.

TL;DR: The demonstration of a vesicular localization and calcium evoked release of cholecystokinin is consistent with a role for chole cysteine-like peptides as a neurotransmitter/neuromodulator in the CNS.

TL;DR: Diazepam and chlordiazepoxide decreased spontaneous single unit activity in the locus coeruleus at relatively low doses, consistent with the actions of several classes of nonbenzodiazepine anxiolytics, and with the involvement of noradrenergic systems in the neural mechanisms of anxiety.

TL;DR: Testing in vitro collagenase production from cultured human breast carcinoma cells which have been well characterized to be mammary epithelial in origin, malignant in karyotype, and able to grow in nude mice suggests a pathologic role of plasminogen activator in the activation of latent collagenase during tumor invasion.

TL;DR: It is estimated that 30% of the urinary free D is derived from circulating free L-DOPA, which is significantly higher than the average level found in innervated and denervated rat kidneys.

TL;DR: The data suggest that the type of pain test is crucial in determining the pattern of drug influences that is revealed, suggesting that variation of stimulus and response parameters can change the functional expression of adrenergic systems related to pain processing.

TL;DR: Results showed that the measurement of hydrocarbons in the rats'breath was a sensitive index of in vivo peroxidation during aging.

TL;DR: The interaction of ketamine HCl with the opiate receptor was stereospecific with the (+) salt being more effective than the (-) salt, consistent with other studies demonstrating that (+) ketamines HCl has a greater analgesic effect than the(-) salt.

TL;DR: The results provide behavioral support for recent biochemical and neurophysiological data which have suggested that chronic DMI administration results in subsensitivity of presynaptic receptors on central noradrenergic neurons.

TL;DR: Prazosin is a novel, selective antagonist of α1-adrenoceptors and can be considered an important advancement both pharmacologically and therapeutically since this compound, in contrast to classical α- adrenoceptor blocking agents, is effective for the treatment of high blood pressure.

TL;DR: Four major ALDH isozymes have been identified in human tissues using starch gel electrophoresis and isoelectric focusing andKinetic characteristics of ALDH I and II were found to be quite similar to ALDH enzyme 2 and enzyme 1 described earlier by Greenfield and Pietruszko.

TL;DR: Scatchard analysis of ligand binding indicated that the decrease in specific binding was due to a decrease in the number of receptors and not to a change in the affinity of the ligand for the receptor.