Showing papers in "Life Sciences in 1984"

TL;DR: It is suggested that the independently developed schemata for classification of dopamine receptors in either the central nervous and endocrine systems or the cardiovascular system are similar although maybe not completely identical.

TL;DR: An important role is suggested for hypothalamic NPY, or a structurally-related peptide, in the regulation of feeding and drinking behavior in satiated, brain-cannulated rats.

TL;DR: In the present study, the in vitro binding of 3H-SCH 23390 to specific striatal receptor sites has been characterized and saturable and stereospecific, and the results of both saturation and competition studies are consistent with the binding of this radioligand to a single striatal site.

TL;DR: The results of this study suggest that the mechanism of action of these agents involves 5-HT2-related events.

TL;DR: Although a biochemical link between endogenousexcitotoxins and human neurodegenerative disorders remains elusive at present, pharmacological blockade of excitotoxicity may constitute a novel therapeutic strategy for the treatment of these disease states.

TL;DR: It is concluded that DA D-1 receptors are as important as D-2 receptors for the expression of neuroleptic activity in most animal models believed to be predictive of antipsychotic and extrapyramidal side-effect potential.

TL;DR: Findings suggest that neuropeptide Y may play a role in regulation of LH release in the rat, either independently or in concert with catecholamines.

TL;DR: Synthetic atrial natriuretic factor inhibited aldosterone production by suspensions of bovine adrenal glomerulosa cells and had no effect on binding of AII to receptors, on the stimulation by A II of phospholipid turnover, or on the alteration by AII of calcium fluxes.

TL;DR: The results suggest that the central serotonergic system is less responsive in depressed patients than controls, and fenfluramine, a serotonin releasing agent, was administered to 18 depressed patients and 10 controls.

TL;DR: The data suggest that the hypothalamic and neurohypophysial contribution to the control of ACTH secretion may vary in response to different types of stress.

TL;DR: Three major classes of chlorinated hydrocarbon insecticides, i.e., the lindane/hexachlorocyclohexane, toxaphene and aldrin/dieldrin types, are potent, competitive, and stereospecific inhibitors of t-butylbicyclophosphorothionate (TBPS) binding to brain-specific sites, thereby indicating an action at the gamma-aminobutyric acid (GABA)-regulated chloride channel.

TL;DR: The results suggest that both spontaneous activity and sensitivity to DA agonists may be determined by the density (or sensitivity) of DA autoreceptors on A10 DA neurons.

TL;DR: It is observed that naloxone reversed human fibroblast interferon mediated enhancement of human blood lymphocyte natural killer function, suggesting that circulating endogenous opioid peptides may have a physiologic role in regulating human bloodymphocyte natural killing.

TL;DR: A very good correlation was observed between their relative affinities for the [35S]-TBPS binding site and their convulsant potencies, indicating that pentamethylenetetrazol and related tetrazoles may produce their Convulsant and anxiogenic actions via the GABA-benzodiazepine-chloride ionophore receptor complex.

TL;DR: In vitro competitive inhibition of sparteine oxidation by a drug indicates that this drug is capable of occupying the same enzymatic site as spartanine and may mean that the competing drug is also metabolized at that site and thereby subject to the same genetic variation as spartein's oxidation.

TL;DR: The results document the specific receptor involved in the potent inhibitory effect of ANF on adrenal steroidogenesis and indicate that bovine adrenal zonal glomerulosa provide a highly sensitive system for studying the recently discovered atrial natriuretic factor.

TL;DR: The results suggest that oCRF may act within the hypothalamus to suppress the release of GH and to a lesser extent LH and the stimulation of ACTH release following intraventricular CRF is presumably related to its uptake by portal blood vessels with delivery to the pituitary and stimulation of the corticotrophs.

TL;DR: Three substance K sequences were chemically synthesized and were submitted to parallel bioassays with kassinin, substance P and physalaemin and it is suggested that substance K may have a physiological role which is related to but different from that of substance P in mammalian organisms.

TL;DR: The cyclic hexapeptide, cyclo (Pro-Phe-D-Trp-Lys-Thr-phe), I, has been shown to have the biological properties of somatostatin this paper.

TL;DR: It is demonstrated that cannabinoid and nantradol compounds decrease cyclic AMP accumulation in neuronally derived cells, and that this results from an inhibition of basal and hormone-stimulated adenylate cyclase activity.

TL;DR: Separate regions of the brain where antagonists bind to subtypes of muscarinic receptors are indicated where tritiated pirenzepine and quinuclidinyl benzilate label regions of cerebral cortex, hippocampus, striatum and dorsal horn of the spinal cord.

TL;DR: In the same old rats, the beta-receptor in striata and pineal gland returned towards juvenile values; in the cortex, the modification was in the same direction but did not reach significance.

TL;DR: The hypothesis of a direct activation of the endogenous opiate system following social conflict is supported and feeding and drinking responses were analogous to those observed after administrations of either the endogenous opioid peptide, beta-endorphin, or the exogenous opioid agonist morphine.

TL;DR: The data suggest that the development of both neural and nonneural elements are significantly affected by undernutrition, including processes and substances important for neurotransmission such as transmitter synthesis, degradation and receptor sites.

TL;DR: The observed alterations in adenosine receptor number which occur as a consequence of caffeine consumption may underlie some of the behavioral effects of this cortical stimulant as well as provide insights concerning the mechanisms of tolerance to and dependence on caffeine.

TL;DR: Results show that developmental events are dictated by the duration of opiate receptor blockade and provide compelling evidence that endogenous opioid systems play a crucial role in growth.

TL;DR: Clinical symptoms, biological considerations and prolidase properties, and methods for investigating urinary iminodipeptides are reviewed, leading to a hypothesis for their mechanism.

TL;DR: The results show the pharmacological relevance of peripheral type benzodiazepine binding sites at the cardiac level and the effects of RO5-4864 were GABA-independent and antagonized by PK 11195 but not by the selective antagonist of the brain type benzidiazepine receptors RO15-1788.

TL;DR: The data suggest that GABA "B" receptors may be involved in the mechanism of action of antidepressant drugs and provide a link between GABAergic and monoaminergic hypotheses of depression.