Showing papers in "Life Sciences in 1985"

TL;DR: Compromise of mitochondrial oxidative capacity by MPP+ could be an important factor in mechanisms underlying the toxicity of MPTP.

TL;DR: The binding of radiolabeled bombesin analogue to human small cell lung cancer (SCLC) cell lines was investigated in this article, where the binding was reversible, saturable and specific.

TL;DR: Findings suggest that determinations of 5-HIAA and HVA in CSF from living individuals may reflect brain metabolite levels as well as the functional activity of these specific neuronal systems.

TL;DR: Single unit recordings were obtained from putative dopaminergic neurons in the substantia nigra of awake, freely moving rats, and in several cases, a putative DA neuron was observed to fire all of its spikes in near coincidence with at least one other cell with identical electrophysiological characteristics.

TL;DR: Oxygen consumption and the activities of the selenoenzyme glutathione peroxidase, and of the hexose monophosphate shunt were lower than normal in neutrophils from Se deficient cattle, but the activity of Cu/zinc superoxide dismutase were unaffected and impaired neutrophil microbicidal activity previously demonstrated to result from Se or Cu deficiency in cattle was discussed.

TL;DR: The persistent metabolite retained by the monkey brain was MPP+, while MPP+ cannot be detected in rodent brains for more than a few hours after injection.

TL;DR: Both in men and rats, most of the ethanol ingested at a low dose is metabolized before it reaches the systemic circulation, and this "first pass" metabolism (FPM) may be viewed as a barrier which protects against the systemic toxicity of ethanol.

TL;DR: The large body of evidence presented indicates that in the brain the action of sex hormones cannot be thought as restricted to the regulation of endocrine functions and mating behavior and that these hormones may modulate neuronal activity through a wide variety of mechanisms.

TL;DR: After administration of toxic doses of MPTP, the concentration of MPP+ in the substantia nigra appears to increase during the first 72 hours, reaching the highest concentration of any central nervous system (CNS) tissue studied.

TL;DR: It is speculated that the neurotoxicity of MPTP is mediated by its intraneuronal oxidation to MPDP+, a reaction which appears to be catalyzed by MAO.

TL;DR: A substantial escape of plasma cortisol from dexamethasone suppression was observed and ACTH responses changed in concordance with those of cortisol indicating that the LVP-CRF interaction takes place at the pituitary level.

TL;DR: Data indicate that some mini-somatostatins bind to a subpopulation of SS receptors in rat brain, and the iodinated Tyr3-derivative (125I-204-090) can be considered a selective radioligand for one rat brain SS receptor subpopulation.

TL;DR: Results demonstrate that in the 2-3 month-old female Zucker rat, the fa allele is associated with defective regulation of insulin in the brain.

TL;DR: Differences in Ki-values indicate the possibility of different binding sites for DA and 3H-SCH 23390 or, that DA and3H- SCH 233 90 label different states of the same receptor.

TL;DR: The present behavioral, neurochemical and histological results indicate that MPTP produces an ideal primate model for studying parkinsonism.

TL;DR: It is shown here how the calcium channel modulators interact with the binding sites to increase or decrease calcium flux, and hence to modulate the activity of many excitable tissues.

TL;DR: The results suggest that in the heart the peripheral type benzodiazepine receptors are coupled to calcium channels.

TL;DR: Histological evidence is presented which suggests the usefulness of this system for hepatotoxicity studies and the production of focal necrosis in vitro and addition of bromobenzene to the culture showed time-dependent hepatot toxicity based on two classic parameters of cell degeneration.

TL;DR: A review of the role of gamma-aminobutyric acid (GABA) in the autonomic nervous system and its role in neuronal and non-neuronal tissues can be found in this article.

TL;DR: Determination of salivary testosterone is a reliable method to detect changes in the concentration of available biologically active hormone in the circulation and was significantly increased in subjects taking oral contraceptives and most of the hypertensive patients the total serum testosterone concentration was in normal range.

TL;DR: It is concluded that random prenatal noise and light stress increases the vulnerability to stressful situations in the female offspring during adulthood, which may be accompanied by altered CA function in the hypothalamus and BZ binding in the hippocampus.

TL;DR: It is concluded that the synthetic ANF increased electrolyte excretion via a direct renal action which was not solely dependent upon changes in renal vasculature, renin secretion or cyclic GMP levels.

TL;DR: The effect on emotional reactivity produced by a model for chronic stress in which different types of acute stresses were randomly combined for 29 days was studied in adult male rats, showing a slight decrease in body weight gain and an increase in relative adrenal weight.

TL;DR: The syndrome of MPTP intoxication can be divided into three and possibly four phases, and the potential underlying mechanisms for the clinical and behavior observations of each phase are discussed.

TL;DR: The results indicate that glycinergic neurons contribute to the tonic regulation of nociceptive input at the spinal cord in rats treated with strychnine or glycine.

TL;DR: The hypothesis that central cholinergic systems are involved in the retention of learned responses in adult rats is supported, and the postacquisition administration of the acetylcholinesterase inhibitor, physostigmine, is suggested to be reversed.

TL;DR: Positive correlation was found between the degree of reversible AChE inhibition by pretreatment, coupled with therapy, and efficacy against soman lethality and the present data indicate that inhibition levels as low as 10% may provide some protection.

TL;DR: In rats with a unilateral 6-OHDA lesion of the substantia nigra exposure to footshock or immobilization stress, it is suggested that stress may induce enduring changes in brain and behavior similar to those produced by psychomotor stimulant drugs.

TL;DR: Results indicate that relaxin is involved in the regulation of blood pressure during gestation, and infusion of purified rat relaxin markedly reduced systolic blood pressure for at least 5 or 6 days in spontaneously-hypertensive rats.

TL;DR: A reverse-phase high-performance liquid chromatographic (HPLC) method is developed that separates the two major metabolites from each other and from amodiaquine, allowing separate quantification.