Showing papers in "Life Sciences in 1986"

TL;DR: Anatomic and physiological studies suggest a varied, but important, function for NPY in mammalian nervous system and circulating levels of NPY may prove useful in the diagnosis of pheochromocytoma.

TL;DR: It is proposed that these receptors may be subclassified as M2 cardiac type and M2 glandular type muscarine receptors, which are clearly distinct in the heart and exocrine glands.

TL;DR: This review will address both the biochemical and pharmacological evidence supporting the existence of a common site with very high affinity for both enkephalins and opiates termed tht mu1 site.

TL;DR: This animal hemiparkinsonian model will be useful in studies of volitional movement control, drug treatments of Parkinson's disease, and functional efficacy of brain tissue implants.

TL;DR: AF-DX 116 clearly distinguishes between M1- and M2-mediated responses; it also emphasizes the long-recognized heterogeneity among the peripheral M2 subtypes, and may have a therapeutic potential in the treatment of sinus bradycardia.

TL;DR: The demonstrated difference between the LS and SS mice in muscimol stimulated chloride uptake as well as in musCimol displacement of [35S]TBPS binding offers a biochemical explanation for the line differences in behavioral responses to GABAergic agents.

TL;DR: These studies show that alpha h-ANP is rapidly metabolized at rates similar to other vasoactive hormones such as angiotensin II and vasopressin.

TL;DR: Evidence is provided that alterations in calcium conductance may be involved in the ethanol withdrawal syndrome and possibilities for the development of non-sedative therapeutic treatment of this syndrome are offered.

TL;DR: Tests in awake rats with probes in the nucleus accumbens showed stable amounts of catecholamines and metabolites collected during repeated 20 min samples, and absolute recovery measured in picograms was independent of the perfusate flow rate inside the probe.

TL;DR: The skin permeabilities of a series of eight salicylates and ten non-steroidal anti-inflammatory drugs were investigated in human subjects and a parabolic relationship was obtained in both compound series.

TL;DR: The distribution of CGRP in the central and peripheral nervous system and its co-localization in some neurons with substance P (SP) or acetylcholine suggests several possible roles in autonomic, sensory and motor functions.

TL;DR: A rapid, simple and sensitive assay has been developed for tyrosine-3-monooxygenase, the enzyme catalyzing the rate-limiting step in catecholamine biosynthesis.

TL;DR: It is speculated that progesterone may exert its antimotility effects on the uterus via uteroglobin which, by inhibiting PLA2, decreases arachidonic acid release and subsequently reduces prostaglandin levels in this organ.

TL;DR: Energy-driven uptake of MPP+ by brain mitochondria may be a crucial step in the complex sequence of events leading to the neurotoxic actions of its precursor, MPTP.

TL;DR: The opiate blocker naltrexone prevents the expected post-shock increase of ethanol consumption in rats, providing further evidence that endogenous opiates are involved in the voluntary drinking of ethanol in rats.

TL;DR: It is possible that carbonyl groups of MDA could interact with primary amino groups of proteins and phospholipids of lenticular plasmalemmae by a cross-linking reaction forming Schiff-base conjugates and these mechanisms might be involved in the pathogenesis of cataract.

TL;DR: The Genetically Epilepsy-Prone Rat (GEPR) is rapidly gaining support as a model of epilepsy, and the relative potencies of anticonvulsant drugs between the two colonies of GEPRs predict the clinical efficacies of traditional antiepileptic drugs and may be able to predict novel anticonVulsants.

TL;DR: The Bernard B. Brodie Lecturer has trained large numbers of scientists from all over the world, and many of these scientists have become today's leaders in pharmacology and in the related biomedical sciences.

TL;DR: The hypothesis that behavioral effects of CRF are mediated by its action at central sites and not via an action on the pituitary-adrenocortical system is supported.

TL;DR: The results of the experiments presented here are interpreted as an involvement of more than one opioid receptor types in the regulation of appetite, possibly with separate opioid systems contributing to food and water intake.

TL;DR: If the antipsychotic activity of rimcazole is confirmed in double-blind, placebo-controlled trials, it would be the first compound whose mechanism of antipsychotics activity may best be explained by a direct blockade of sigma sites and not by adirect blockade of dopamine (D2) receptors in brain.

TL;DR: In blowfly salivary gland membranes, 5-hydroxytryptamine stimulates a guanine-nucleotide dependent breakdown of both endogenous and exogenous phosphoinositide substrate through activation of phospholipase C, suggesting that a GTP-binding protein modulates phospholIPase C activity.

TL;DR: It is shown that genetic or developmental factors resulting in a lesser number of D2--relative to D1--receptors is associated with repetitive jaw movements, and in two strains of rats with different striatal D2 to D2 ratios, the strain with fewer D2 sites had more jaw movements.

TL;DR: The purpose of the present article is to review the understanding of diabetes-induced myocardial problems and their possible causes, and to describe attempts to normalize cardiac function.

TL;DR: This effect explains, at least in part, the ANF-induced decrease in cardiac output and blood pressure in normotensive animals and may play an important role in the homeostatic regulation of plasma volume.

TL;DR: The results suggest that during conditioning, the effects of cocaine on dopamine neurons may have produced a change that subsequently influenced behaviour even when dopaminergic systems were blocked.

TL;DR: CDS represents an as-yet-uncharacterized endogenous, physiologically-active agent in brain which may participate in cardiovascular control via non-adrenergic receptors in the rostral ventrolateral medulla.

TL;DR: Several polyhydroxy alkaloids, including the eight presently known to occur in plants, have been compared as inhibitors of mouse gut digestive disaccharidases and the indolizidine castanospermine inhibited all activities tested, but others showed a selectivity which could be of value in studies of carbohydrate digestion and errors of metabolism.

TL;DR: Findings indicate that GABAergic activity contributes to the tonic modulation of nociception at the spinal cord with respect to GABA agonists and antagonists injected intrathecally atThe spinal cord.