Showing papers in "Life Sciences in 2002"

TL;DR: The results of the present work suggest that the anti-inflammatory activities of the same extracts could be explained, at least in part, by their antioxidant properties.

TL;DR: It is concluded that BDNF/TrkB signaling plays an important role in learning and memory and may be linked to the modulation of NMDA and non-NMDA receptor functions as well as the expression of synaptic proteins required for exocytosis.

TL;DR: Three berberine, berbamine and palmatine alkaloids were shown to possess dose-dependent antinociceptive activity, which assessed by using the model based on the inhibition of p-benzoquinone-induced writhing movements as well as antipyretic activity on FCA-induced increased rectal temperature on subacute administration.

TL;DR: Three new isoflavonoids with a pyran ring, gancaonols A[bond]C, were isolated together with 15 known flavonoids and exhibited anti-H.

TL;DR: It is concluded that TT extract appears to possess aphrodisiac activity probably due to androgen increasing property of TT (observed in an earlier study on primates).

TL;DR: This study provides first evidence of effectiveness of trans resveratrol in focal ischemia most probably by virtue of its antioxidant property and prevents motor impairment, rise in levels of MDA and reduced glutathione and also significantly decreased the volume of infarct as compared to control.

TL;DR: The effectiveness of trans resveratrol in preventing the cognitive deficits as well as the oxidative stress caused by ICV STZ in rats and it's potential in the treatment of neurodegenerative diseases such as Alzheimer's disease are demonstrated.

TL;DR: All the extracts with the highest acetylcholinesterase inhibitory activity contained galanthamine except that of N. assoanus, a lycorine type alkaloid-bearing species.

TL;DR: In this paper, the authors explored the potential role of these issues and medication in terms of increased morbidity and mortality observed in schizophrenia and found that overactivity of the hypothalamic-pituitary-adrenal axis leading to hypercortisolaemia can also result in excessive visceral fat accumulation.

TL;DR: The results suggest that P-gp is likely to influence the access to the brain of all of the atypical antipsychotics studied to various degrees, and in vivo studies are needed to confirm these findings.

TL;DR: It is concluded that lower plasma kynurenine at the end of term is the consequence of lower plasma tryptophan, and that depressive and anxiety symptoms in the early puerperium are (causally) related to an increased catabolism of tryPTophan into knurenine, a phenomenon which probably results from immune activation.

TL;DR: It is suggested that aloe-emodin may be useful in liver cancer prevention because it inhibited cell proliferation and induced apoptosis in both examined cell lines, but with different the antiproliferative mechanisms.

TL;DR: The biochemical data show that the extract of S. verticillatus elicited a significant antidepressant-like effect, when assessed in the TST and FST in mice, which seems to involve an interaction with adrenergic, dopaminergic, glutamatergic and serotonergic systems.

TL;DR: St. John's wort (Hypericum perforatum L.) is a medicinal plant traditionally used, both externally and internally, in all Europe for many pathologies as discussed by the authors.

TL;DR: Induction of atherosclerotic lesions in several animal models including rodents, rabbits, rats, hamsters, guinea pigs, avian, swine, carnivora, and non-human primates is discussed.

TL;DR: Age-related changes in the size and the signal intensities of the subregions of the corpus callosum in the Magnetic Resonance Imaging (MRI) scans of a cross-sectional sample of 109 healthy young individuals suggested parallel maturation of diverse brain regions during childhood and adolescence.

TL;DR: Astaxanthin improves antitumor immune responses by inhibiting of lipid peroxidation induced by stress, and is suggested to improve immunological dysfunction induced by restraint stress.

TL;DR: It was confirmed that histamine and H1Rs are involved in maintaining arousal and cognition in humans, and that the severity of clinical symptoms is correlated to the amount of antihistamine that penetrated into the brain.

TL;DR: It was demonstrated that the resveratrol effectively inhibited cell growth and induced programmed cell death in Hepatoma cells on a molecular basis and implied that resver atrol might also be a new potent chemopreventive drug candidate for liver cancer.

TL;DR: BVA is the effective fraction of whole BV responsible for the antinociception and anti-inflammatory effects of BV acupuncture treatment and it is recommended that this fraction of BVA be used for long-term treatment of RA-induced pain and inflammation.

TL;DR: Bark extract is more effective than melatonin, vitamin E, desferrioxamine and alpha-phenyl N-tert butylnitrone, the known antioxidants having antiulcer effect and well tolerated by rats with no significant adverse effect.

TL;DR: The results showed that the water-extract of Paeoniae Radix (PRE) had inhibitory effect on the growth of both HepG2 and Hep3B cell lines, indicating that the cytotoxicity of PRE to the hepatoma cells is through activation of the cell death program, apoptosis.

TL;DR: It is suggested that a PPARgamma-Bcl-2 feedback loop may function to control the life-death continuum in colonic cells and that a deficiency in generation of PPargamma ligands may precede the development of human colon cancer.

TL;DR: GLIS stimulated the proliferation of mouse spleen lymphocytes, resulting in a three to four-fold increase in the percentage of B cells, and is a new B cell-stimulating factor.

TL;DR: This review will concentrate on the distribution of NPY, its receptors, and the putative role played by this peptide in depressive illness based on both pre-clinical and clinical evidence.

TL;DR: Results showed that chronic garlic intake dose dependently augmented endogenous antioxidants, which might have important direct cytoprotective effects on the heart, especially in the event of oxidant stress induced injury.

TL;DR: This is the first study to demonstrate an effect of moderate levels of noise on neuroendocrine activity and the impact of long-term exposure to moderate noise levels, and particularly low frequency noise, in the workplace deserves further investigation.

TL;DR: The antioxidant content of the aqueous extracts was substantial, ranging from 27 to 972 micromol Trolox equivalent per gram dry weight, and an extract of the leaves of the plant Ilex paraguensis contained the highest amount of antioxidant.

TL;DR: The results imply that A. camphorata mycelia may have protective antioxidant and anticancer properties.

TL;DR: The data support the contention that MCI-186 reduces reperfusion injury in perfused hearts with prolonged ischemia and the mechanism for the in vivo efficacy of MCi-186 is predominantly related to its antioxidant activities.