Showing papers in "Life Sciences in 2005"

TL;DR: Several compounds from tropical rainforest plant species with potential anticancer activity have been identified and several compounds, mainly from edible plant species or plants used as dietary supplements, that may act as chemopreventive agents are isolated.

TL;DR: The chemical constituents of the plant are discussed with particular emphasis on the cannabinoids as the class of compounds responsible for the drug's psychological properties.

TL;DR: It is suggested that hydrophobic amino acids present in peptide sequences contributed greatly for observed antioxidants activities and radical scavenging potency of these peptides.

TL;DR: This review focuses on the CB1-selective antagonists, SR141716A, AM251, AM281 and LY320135, and discusses possible mechanisms by which these ligands produce their inverse effects.

TL;DR: The mechanism of apoptosis induced by DOX in the human leukemia cell line HL-60 and the H(2)O(2)-resistant sub-clone, HP100 was investigated, suggesting that the critical apoptotic trigger of DOX is considered to be oxidative DNA damage by the DOX-induced direct H( 2)O (2) generation, although DOx-induced apoptosis may involve topoisomerase II inhibition.

TL;DR: Specific biological activities of indole alkaloids presented here include: cytotoxicity, antiviral, antiparasitic, anti-inflammatory, serotonin antagonism, Ca-releasing, calmodulin antagonism and other pharmacological activities.

TL;DR: Results demonstrate that febuxostat is a potent non-purine, selective inhibitor of XO, and could be useful for the treatment of hyperuricemia and gout.

TL;DR: This is the first report of tumor cell proliferation inhibitory activity by anthocyanidins, and cyanidin, delphinidin and petunidin inhibited the breast cancer cell growth by 47, 66 and 53%, respectively.

TL;DR: Results indicate that over a short-term, a high-dose of selenite caused more pronounced oxidative stress, greater liver injury, and prominent retardation of growth as compared to Nano-Se.

TL;DR: The results suggest that the main inhibitory mechanism of the platycodin saponins may be the reduction of iNOS and COX-2 gene expression through blocking of NF-κB activation.

TL;DR: The ligand-activated transcription factor, peroxisome proliferator-activated receptor-alpha (PPAR-alpha), is identified as the receptor mediating the anti-inflammatory actions of this lipid amide.

TL;DR: The beneficial effect of algal carotenoid compared to synthetic carotene as antioxidant in Dunaliella can be further extended to exploit, its possible application for various health benefits as nutraceuticals and food additive.

TL;DR: Through in vivo bioassay-guided fractionation processes isoorientin, a known C-glycosylflavone, was isolated from the ethylacetate fraction by silica gel column chromatography as the main active ingredient from the plant to establish a correlation between the hypoglycaemic activity.

TL;DR: The cytotoxic survival curve showed that CHA does not have cytot toxic effects on cellular proliferation, when Hep3B cells were treated with various concentrations of CHA and cell viability was measured using the XTT assay, suggesting a clue for possible mechanisms of cancer chemoprevention by CHA

TL;DR: TBBPA, TCBPA, TMBPA and DMBPA can act as thyroid hormone-disrupting agents, and TBBPA showed suppressive action on T3 (5 x 10(-8) M)-enhancement of Rana rugosa tadpole tail shortening.

TL;DR: NAR reduced the extent of cisplatin-induced nephrotoxicity, as evidenced by significant reduction in serum urea and creatinine concentrations, decreased polyuria, reduction in body weight loss, and marked reduction in urinary fractional sodium excretion and glutathione S-transferase (GST) activity.

TL;DR: The results indicated that crocin could inhibit the formation of atherosclerosis in quails and had protective effects on endothelial cells.

TL;DR: This report is the first that shows hepatoprotective effects of Hibiscus, Rosmarinus and Salvia species against Azathioprine-induced acute liver damage and it is shown that animals pretreated with water extracts from any of the three herbs under investigation not only failed to show necrosis of the liver after azathiopine administration, but also retained livers that, for the most part, were histologically normal.

TL;DR: The data suggest that the inhibitory effects of Cl.Cr are mediated primarily through calcium channel blockade, though additional mechanism cannot be ruled out and this study forms the basis for the traditional use of turmeric in hyperactive states of the gut and airways.

TL;DR: Results confirm that BG undergoes extensive first-pass glucuronidation and that enterohepatic circulation contributes significantly to the exposure of BG and BGM in rats.

TL;DR: The results suggest that orally administrated P. baumii EPS exhibited considerable hypoglycemic effect in STZ-induced diabetic rats and that these EPS may be useful for the management of diabetes mellitus.

TL;DR: The results suggest that SGLT4 would have unique physiological functions (i.e., absorption and/or reabsorption of Man, 1,5AG, and Fru, in addition to Glc) and be a low affinity-type transporter.

TL;DR: Findings indicate that yellowfin sole anticoagulant protein YAP binds with FXIIa and platelet membrane integrins to inhibit thrombosis in vitro.

TL;DR: MiADMSA was the most effective chelator in reducing ROS in red blood cells, and in restoring blood ALAD compared to two other chelators, and showed maximum reduction in the level of ROS in brain, as well as recovery in the altered biochemical variables particularly suggestive of oxidative stress.

TL;DR: It is demonstrated that naringin protects mouse liver and intestine against the radiation-induced damage by elevating the antioxidant status and reducing the lipid peroxidation.

TL;DR: Intensive, random time sampling appears to have advantages over fixed time sampling for obtaining valid cortisol profiles when researchers do not have devices to monitor compliance, and indirectly support the validity of momentary self-report data about daily experiences obtained with the same sampling methods.

TL;DR: The results show that the Music group had significantly higher cortisol levels at T3, that is, when cortisol levels are assumed to reflect the stress induced by the game.

TL;DR: The results showed that apigenin significantly decreased the viability of HeLa cells at 37-74 microM and the IC50 value was 35.89 microM, suggesting that apigin has strong potential for development as an agent for preventing cervical cancer.

TL;DR: The present review provides cross-linkage to the most recent literature on anti-TB active natural products and summarizes the recent developments in both fields and their potential to impact the early steps of the TB drug discovery process.

TL;DR: RK prevents and improves obesity and fatty liver and appears to stem from the action of RK in altering the lipid metabolism, or more specifically, in increasing norepinephrine-induced lipolysis in white adipocytes.