Showing papers in "Life Sciences in 2006"

TL;DR: This review summarizes the most interesting in vitro and in vivo studies on the biological effects of curcumin, the constituent of turmeric, which has been widely studied for its anti-inflammatory, anti-angiogenic,Anti-oxidant, wound healing and anti-cancer effects.

TL;DR: The antioxidant properties of the L-carnitine were evaluated by using different antioxidant assays such as 1, 1-diphenyl-2-picryl-hydrazyl free radical (DPPH.) scavenging, total antioxidant activity, reducing power, superoxide anion radical scavenge, hydrogen peroxide scavenging and metal chelating activities.

TL;DR: Dose-related differences in the effects of EGCG in cancer versus neurodegenerative and cardiovascular diseases, as well as discrepancies between doses used in in vitro studies and achievable plasma understanding of the in vivo effects of green tea catechins in humans, are summarized.

TL;DR: This study confirmed that the number and position of hydroxyl groups and the related glycosylation and other substitutions largely determined radical scavenging activity of the tested phenolic compounds.

TL;DR: An expanding body of evidence support that members of the vitamin E family are functionally unique, and title claims in manuscripts should be limited to the specific form of vitamin E studied.

TL;DR: It is suggested that administration of oleuropein may be helpful in the prevention of diabetic complications associated with oxidative stress and in inhibiting hyperglycemia and oxidative stress induced by diabetes.

TL;DR: The objective was to establish an experimental procedure and show direct AFM measurements that unequivocally can be assigned as a surrogate for AFM in mice and show clear AFM signal constellations similar to those in humans.

TL;DR: The more elevated ACE2 in young adults as compared to aged groups may contribute to the predominance in SARS attacks in this age group.

TL;DR: The current literature regarding the interactions of flavonoids with ATP-binding cassette (ABC) efflux transporters, mainly P-glycoprotein, MRP1,MRP2 and BCRP are summarized and the potential consequences for flavonoid-drug transport interactions are discussed.

TL;DR: The global scenario of prevalence and methods used for detection of AR in small ruminants and various options and alternate strategies for the control and/or delay in the onset of AR are suggested in the light of available information.

TL;DR: Clinical implications of such drug herbal interactions depend on a variety of factors such as dose, frequency and timing of herbal intake, dosing regimen, route of drug administration and therapeutic range.

TL;DR: The results suggest that the present model fulfills adequate face, construct and predictive validity as an animal model of mania.

TL;DR: The findings demonstrate that GA-T induced apoptosis of metastatic lung tumor cells through intrinsic pathway related to mitochondrial dysfunction and p53 expression, and it may be a potentially useful chemotherapeutic agent.

TL;DR: EGCG is a novel phytochemical inducer of HO-1 expression and the principal underlying mechanisms involved in this process are identified.

TL;DR: Genistein and ISP supplements seem to be beneficial for correcting the hyperglycemia and preventing diabetic complications.

TL;DR: The phenolic compounds studied here showed protective potential against oxidative damage induced in HepG2 cells, which could be beneficial against liver diseases where it is known that oxidative stress plays a crucial role.

TL;DR: A practical and repeatable new rat model of steatohepatitis was established by feeding with high-fat emulsion via gavage and reproduces many of the clinical indices of human NASH.

TL;DR: The purpose of this review is to summarize the results of these recent studies and to discuss the implications of these findings with regard to the mechanisms of Cd toxicity in specific organs including the lung, liver, kidney, testis and heart.

TL;DR: At effective doses in the behavioral tests, mice showed no impairment on rotarod procedure after both single and repeated treatments with essential oil, denoting absence of motor deficit.

TL;DR: For these oils a significant correlation between antiplatelet potency and phenylpropanoids content was evidenced thus suggesting a key role for this moiety in the prevention of clot formation.

TL;DR: The present review focuses on the complexity of I/R injury, summarizing conflicting results obtained from the literature about the mechanisms responsible for it and considering new potential protective strategies using trimetazidine, 5-amino-4-imidazole carboxamide riboside, melatonin, modulators of the renin-angiotensin system (RAS) and the phosphatidylinositol-3-OH kinase (PI3K)-Akt.

TL;DR: Although the ERα activation potential of the pesticides was lower than that of estradiol, the overall body scale response might be amplified by the ability of pesticides to act via several mechanisms and by frequent and prolonged exposure to different pesticides, even at low concentrations.

TL;DR: G gelatin zymography clearly revealed that both MMP expression and activity in cells can be inhibited by EC extract, and EC extract did not exert any cytotoxic effect even at 100 microg/ml anticipating its potential use as a safe MMP inhibitor.

TL;DR: It can be concluded that the consumption of MRBF-2 and (MRBF-3, in some extent) fractions of M. alba L. root bark may act as a potent hypocholesterolemic nutrient and powerful antioxidant via the inhibition of LDL atherogenic modifications and lipid peroxides formation in hypercholesterolesmic rats.

TL;DR: It is suggested that genistein and daidzein exert anti-diabetic effect in type 2 diabetic conditions by enhancing the glucose and lipid metabolism.

TL;DR: The present findings support the folk reputation of L. barbarum fruits as an aphrodisiac and fertility-facilitating agent, and provide scientific evidence for a basis for the extensive use of the fruit as a traditional remedy for male infertility in China.

TL;DR: Ursolic acid improved the antioxidant status of alcoholic rats, which is evaluated by the decreased levels of lipid peroxidation markers in plasma and increased levels of circulatory antioxidants such as reduced glutathione, ascorbic acid and alpha-tocopherol.

TL;DR: The results of the present study demonstrate that FO may be developed as a useful therapy for hyperlipidemia through reducing hepatic lipids, thereby proving its hypolipidemic activity.

TL;DR: Data indicated that puerarin reduced the atherogenic properties of dietary cholesterol in rats, suggesting that its hypocholesterolemic function may be due to the promotion of cholesterol and bile acids excretion in liver.

TL;DR: The identification of SLC5A8 as a tumor suppressor gene in colorectal cancer marks, for the first time, the association of a plasma membrane transporter with tumor suppressive properties.