Showing papers in "Life Sciences in 2007"

TL;DR: In vitro and animal studies provide strong evidence that polyphenols derived from tea may possess the bioactivity to affect the pathogenesis of several chronic diseases.

TL;DR: Inhibition of HA degradation therefore may be crucial in reducing disease progression and spread of venom/toxins and bacterial pathogens, and potent, ubiquitous regulating agents that are involved in maintaining the balance between the anabolism and catabolism of HA.

TL;DR: Alcohol-induced oxidative stress is linked to the metabolism of ethanol involving both microsomal and mitochondrial systems and elevates malondialdehyde, hydroxyethyl radical, and hydroxynonenal protein adducts and causes the modification of all biological structures and consequently result in serious malfunction of cells and tissues.

TL;DR: Nitric oxide participates in the control of contractility and heart rate, limits cardiac remodeling after an infarction and contributes to the protective effect of ischemic pre- and postconditioning, as well as being involved in reduced contractile response to adrenergic stimulation in heart failure.

TL;DR: The data suggest that, by blocking NF-κB and AP-1 activation, luteolin acts to suppress the LPS-elicited inflammatory events in mouse alveolar macrophages, and this effect was mediated, at least in part, by inhibiting the generation of reactive oxygen species.

TL;DR: Dietary supplementation with resveratrol during ethanol treatment inhibited hepatic lipid peroxidation and ameliorated SOD, GPx and CAT activities in the liver, and caused drastic alterations in antioxidant defence systems.

TL;DR: Up-regulation of the progenitor cell proliferation of hippocampus and cytoprotective activity might be mechanisms involved in the antidepressant-like effect of piperine, which may be closely related to the elevation of hippocampal BDNF level.

TL;DR: It is indicated that WEP and caffeoylquinic acid derivatives have neuroprotective effects against retinal damage in vitro, and that these effects may be partly mediated via antioxidant effects.

TL;DR: The results suggest that the lymphocytic cholinergic system is activated by ACh via mAChR- and nAchR-mediated pathways during antigen presentation between T cells and DCs or macrophages, leading to modulation of immune cell function.

TL;DR: Results indicate that CYP2C9 and CYP3A4 are major enzymes involved in the 11-hydroxylation and the 8-(or the 7-) hydroxylations, respectively, of the cannabinoids by human hepatic microsomes.

TL;DR: Findings indicate that human small intestine and liver show extensive hydrolase activity attributed to CES, which is different from that in species commonly used as experimental animals.

TL;DR: Icariin, which was more potent than icariin and icariside II, enhanced the differentiation and proliferation of osteoblasts, and facilitated matrix calcification; meanwhile it inhibited osteoclastic differentiation in both osteoblast-preosteoclast coculture and osteoclast progenitor cell culture, and reduced the motility and bone resorption activity of isolated osteoclasts.

TL;DR: Results of the present study suggest the potential of resveratrol in treatment of diabetic neuropathy and its protective effect may be mediated through reduction in oxidative stress and DNA fragmentation.

TL;DR: The studies suggested that AGB supports predominantly Th1 immunity with increase in macrophage functions and might therefore, find useful applications against the intracellular pathogens and in the management of immune suppressed diseases.

TL;DR: The chemical nature of newAntimalarial compounds showing antimalarial activity through the inhibition of hemozoin formation has been incorporated, which may help to design future antimalarials with therapeutic potential against multi-drug resistant malaria.

TL;DR: The data suggest that the consumption of HP diet leads to an obese phenotype, increases protein oxidation in frontal cortex and appears to induce anxiety-like behavior in rats.

TL;DR: The findings support the view that BER exerts antidepressant-like effect and may be related to the increase in NA and 5-HT levels in the hippocampus and frontal cortex.

TL;DR: There is a large body of evidence suggesting that the regulation of ion transport by Na(+), K(+)-ATPase is not the only physiological role of DLC, and the evidence for the different aspects of DLC action is evaluated and open questions are delineated.

TL;DR: Observations indicate that acetylcholine release from urothelial cells is mediated by different mechanisms than those such as vesicular storage and exocytosis that underlie the release of neurotransmitters from nerves.

TL;DR: It is suggested that the spice-derived components can suppress obesity-induced inflammatory responses by suppressing adipose tissue macrophage accumulation or activation and inhibiting MCP-1 release from adipocytes.

TL;DR: The results indicate that the mechanisms contributing to the hypoglycemic effect of resveratrol include insulin-dependent and insulin-independent pathway, and PI3K-Akt-signaling was involved in the latter mechanism to enhance glucose uptake in skeletal muscle.

TL;DR: The human urothelium carries multiple cholinergic receptor subtypes, with predominant expression of M2R, M3R and alpha7-nAChR, and it is proposed that this layer-specific distribution serves to stratify cholinergic regulation of human Urothelial function.

TL;DR: Experimental evidence indicates that vagus nerve cholinergic anti-inflammatory signaling requires alpha7 nicotinic acetylcholine receptors expressed on non-neuronal cytokine-producing cells, which can be exploited in therapeutic approaches directed towards counteracting abnormal chronic and hyper-activated inflammatory responses.

TL;DR: Results indicate that naringenin chalcone exhibits anti-inflammatory properties by inhibiting the production of proinflammatory cytokines in the interaction between adipocytes and macrophages.

TL;DR: The data indicate that ROS signaling is an essential trigger of ischemic and pharmacological PostC and this is occurring at the level of the cardiac myocyte.

TL;DR: This study indicates that HES had a markedly immunomodulatory effect in a clinically relevant model of ARDS, Nevertheless, further investigations are required to determine the potential clinical usefulness of HES in the adjunctive therapy of AR DS.

TL;DR: The data indicate that anti-diabetic and insulin-sensitizing activities of ginsenosides, at least in part, are involved in the enhancing effect on PPARγ2 and C/EBPα expression, hence promoting adipogenesis.

TL;DR: TMCO-60%/pDNA nanoparticles had better in vitro and in vivo transfection activity than the other two, and with minimal toxicity, which made it a desirable non-viral vector for gene therapy via oral administration.

TL;DR: Plasma LPA level and serum ATX activity are increased in various liver injuries in relation to their severity, and whether increased ATX and LPA in the blood in liver injury is simply a result or also a cause of the injury should be further clarified.

TL;DR: It is suggested that SVFs might be used to promote angiogenesis in ischemic tissues by augmenting collateral development as determined by the restoration of blood perfusion and capillary density of the isChemic muscle.