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Showing papers in "Life Sciences in 2015"


Journal ArticleDOI
TL;DR: The results of the recent basic and clinical studies revealed the beneficial effects for Hst, Hsd and their derivatives in the treatment of heart failure and cardiac remodeling, myocardial ischemia and infarction, and hypertension, and the valuable effects of Hst and Hsd in thetreatment of diabetes and dyslipidemia with their anti-platelet and anticoagulant effects make them good candidates in the Treatment of various cardiovascular diseases.

263 citations


Journal ArticleDOI
TL;DR: The current review paper aims to summarize the literatures reporting the pharmacological effects of icariin, the most abundant constituent in Herba Epimedii, which demonstrates extensive therapeutic capacities and is a promising drug candidate in bone tissue engineering.

189 citations


Journal ArticleDOI
TL;DR: The molecular mechanisms, particularly the epigenetic regulation mechanisms, involved in leptin resistance associated with obesity and the therapeutic potential of these molecular mechanisms in the battle against the obesity pandemic are discussed.

183 citations


Journal ArticleDOI
TL;DR: What is new in the literature about these kinases is reviewed to establish differences regarding their interacting proteins, activation and function, connecting their roles in the homeostasis of the cell and in pathological conditions.

179 citations


Journal ArticleDOI
TL;DR: The protective activities of Hesperidin and Hst against microbes and several toxicities induced by oxidants, chemicals, toxins, chemotherapy and radiotherapy agents, which were reported in vitro and in vivo are discussed.

132 citations


Journal ArticleDOI
TL;DR: The results indicate that linalool and β-pinene produce an antidepressant-like effect through interaction with the monoaminergic system.

122 citations


Journal ArticleDOI
TL;DR: Together the behavioral, biochemical and neurochemical impairments following the high dose of D-gal suggest that symptoms similar to natural aging may be developed in rats in as early as one week.

109 citations


Journal ArticleDOI
TL;DR: Results reveal a ROS-MAPK mediated mechanism and mitochondrial pathway through which luteolin can protect myocardial ischemia/reperfusion injury.

106 citations


Journal ArticleDOI
TL;DR: A critical review of the available literature is presented to identify the molecular targets underlying the anticancer effects of myricetin.

104 citations


Journal ArticleDOI
TL;DR: Findings indicate that DHA can promote resolution of inflammation by facilitating efferocytosis through M2 macrophage polarization, and may have a therapeutic potential in the management of inflammatory diseases which are related to impaired resolution ofinflammation.

100 citations


Journal ArticleDOI
TL;DR: This study is the first to report that DMY can protect HUVECs from oxidative stress damage, an effect that is mediated by the mitochondrial apoptotic pathways.

Journal ArticleDOI
TL;DR: This study suggests that activation of AMPK might be a novel strategy for the treatment of chronic kidney disease (CKD) partially by inhibition of renal interstitial fibrosis (RIF).

Journal ArticleDOI
TL;DR: It is demonstrated that Ori can activate Nrf2/HO-1 signaling and alleviate apoptosis induced by Aβ1-42, and ameliorate cognitive deficits in AD mice, and might be a potential therapeutic drug for AD.

Journal ArticleDOI
TL;DR: Aged mammals have higher circulating pro-inflammatory cytokines than young adults, supporting the hypothesis of increased inflammation with aging and the potential role(s) of pro- inflammatory and anti-inflammatory macrophages in differentiation and function of osteoblasts and osteoclasts in relation to aging.

Journal ArticleDOI
TL;DR: The results suggested that the polyphenol CGA in coffee protects neurons from glutamate neurotoxicity by regulating Ca(2+) entry into neurons.

Journal ArticleDOI
TL;DR: G-Rg1 may ameliorate the neurological injury, the brain infarct volume and the BBB permeability induced by focal cerebral ischemia in rats and its neuroprotective mechanism is related to the down-regulation of PAR-1 expression.

Journal ArticleDOI
TL;DR: It is suggested that EA can prevent cognitive and LTP deficits and also prevent brain inflammation following TBI.

Journal ArticleDOI
TL;DR: Microalgae may represent an excellent source of nutraceuticals and food supplements once their safety as a food supplement has been confirmed and several preclinical trials and clinical studies supporting the health benefits that most of these compounds may provide.

Journal ArticleDOI
TL;DR: The following review discusses the current state of knowledge related to tumor angiogenesis-regulatory miRNAs and their targets.

Journal ArticleDOI
TL;DR: No induced-hypertension is associated with up-regulation of NADPH oxidase, oxidative stress production and overexpression of key inflammatory mediators, as evidenced by their reversal with AT1R blocker treatment.

Journal ArticleDOI
TL;DR: The MSCs populations derived from different sources, although displaying similar phenotype, exhibited high degree of variability regarding biological properties related to their self-renewal and differentiation capacity, indicating that for more accurate use in cell therapy, individualities of MSCS isolated from different tissues should be identified and taken into consideration when planning their use in clinical protocols.

Journal ArticleDOI
TL;DR: Clinical trials indicate significant efficacy in improving urinary symptoms and mild adverse effects for some phytotherapeutic agents, while further clinical evidence is needed for others (e.g., Epilobium spp., Secale cereale, Roystonea regia).

Journal ArticleDOI
TL;DR: The aim of the current review was to discuss the supposed therapeutic effects of AET on skeletal muscle wasting in both cardiac and cancer cachexia.


Journal ArticleDOI
TL;DR: The molecular mechanisms underlying the generation of oxidative stress-induced vascular dysfunction as well as the beneficial effects of antioxidant therapies are considered.

Journal ArticleDOI
TL;DR: Leptin appears to be strongly involved in mammary carcinogenesis and may contribute to the local pro-inflammatory mechanisms, especially in obese patients, who have increased metastatic potential and greater risk of mortality.

Journal ArticleDOI
TL;DR: The goal of this focused review is to summarize the current knowledge on the role of leptin in OA with particular emphasis on the effects of this adipokine in cartilage and chondrocyte pathophysiology.

Journal ArticleDOI
TL;DR: FA-NE3 exhibited sustained-release profile, better permeability and ultraviolet A (UVA) protection activity as compared to conventional dosage form, and the nanogel could be promising nanocarriers for topical delivery of FA in response to better skin protection activity against UVA rays in a sustained manner.

Journal ArticleDOI
TL;DR: Some doses of rosmarinic acid and CA tested showed neuroprotective action against oxidative and DNA damage produced in the kindling epilepsy model, although they did not produce antiepileptogenic effect in vivo.

Journal ArticleDOI
TL;DR: Fructose-induced hepatic oxidative stress, insulin resistance and inflammation form a triad that constitutes a vicious pathogenic circle that can be effectively disrupted by R/S-α-lipoic acid co-administration, thus suggesting mutual positive interaction among the triad components.