Showing papers in "Life Sciences in 2016"

TL;DR: This review article is the first to establish a precise relation between mice age and human age, following the previous article, which explained the relation in ages of laboratory rats with humans in detail.

TL;DR: The aspects of metabolic disorders-induced oxidative stress in major pathological conditions and strategies for their prevention and therapy are discussed.

TL;DR: It could be concluded that TCM with kidney-tonifying, spleen-tonification, and stasis-removing effects all have the potential effects on treating osteoporosis.

TL;DR: Overall, increased PM levels are highly associated with the development of various skin diseases via the regulation of oxidative stress and inflammatory cytokines, therefore, anti-oxidant and anti-inflammatory drugs may be useful for treating PM-induced skin diseases.

TL;DR: The aim of this review is to summarize all evidence regarding different physiological disruptions in the body and possible involved mechanisms, to prove the association between endocrine disruptions and human diseases.

TL;DR: Ursolic acid could be used as a potential candidate to develop a comprehensive competent strategy towards the treatment and prevention of health disorders and the possible therapeutic effects of UA are described.

TL;DR: The present paper reviews the ways by which free radicals form in the body and promote tissue damage, as well as the role of the antioxidants defense mechanisms.

TL;DR: The protective effects of NAC against oxidative stress caused by pesticide in many organs are focused on and the possible mechanisms of action may be associated to its antioxidant properties.

TL;DR: These findings suggest that chronic occupational exposure to pesticides of lower toxicity than former compounds under integrated production systems elicit mild toxic effects, particularly targeting the skin and eyes, as well as subtle subclinical (biochemical) changes of unknown long-term consequences.

TL;DR: The current acknowledgements about the role of the Wnt canonical pathway in the pathogenesis of some neurodegenerative diseases, with particular regard to the main in vitro and in vivo studies in this field, are summarized by reviewing 85 research articles about.

TL;DR: The novel role of SFKs, particularly c-Src in mediating EMT, modulation of tumor endothelial-barrier, transendothelial migration (microinvasion) and metastasis of cancer cells, and the utility of Src inhibitors in vascular normalization and cancer therapy are reviewed.

TL;DR: This extensive review covers various therapeutic interactions of Curcumin with its recognized cellular targets involved in cancer treatment, strategies to overcome the bioavailability issue and adverse effects associated withCurcumin consumption.

TL;DR: The data indicated that, apigenin could be a useful compound to prevent proliferation and migration of cancer cells as well as CSCs.

TL;DR: Reviewing the current bibliography on cardiotoxicity of nanoparticles and specifically of titanium, zinc, silver, carbon, silica and iron oxide nano-materials is the aim of this study.

TL;DR: The finding suggests that baicalein might be a promising molecule for the prevention of doxorubicin-induced cardiotoxicity in vivo and delineated the possible underlying mechanisms.

TL;DR: A previously unrecognized pathway by which scutellarin protects myocardial I/R injury is identified, probably by enhancing JAK2/STAT3 pro-survival signaling.

TL;DR: An overview of the status of macroglia and microglia in the course of DR is provided, trying to briefly take into account the complex biochemical mechanisms that affect the intimate relationship among neuroretina, vessels and glial cells.

TL;DR: The antioxidant and anti-inflammatory effects of CEP and Pip which were accompanied by inhibition of NF-κB and NLRP3 activation might be helpful mechanisms to halt the progression of DN.

TL;DR: Experimental and clinical evidence with respect to the use of ischemic preconditioning, Ca2+, nitric oxide, and conventional antioxidants in cardiac-reperfusion injury are summarized, and causal therapy approaches with various antioxidants are discussed.

TL;DR: The potential role of polyphenols in the prevention/treatment of dementia is highlighted, the current limitations of research in this field are described and the clinical trials investigated are critically analyzed.

TL;DR: The results promote the introduction of genkwanin in cosmetic preparations, as skin whitening agent, whereas apigenin-7-glucoside and naringenin should be introduced into cosmetic products as natural tanning agents.

TL;DR: The results showed thatmiR-21, miR-206 and let-7a pathways may involve in the anti-angiogenesis effects of the interval exercise training with hormone therapy in mice model of breast tumor.

TL;DR: The study aimed to review the potential association between pre- and post-natal exposure to OCs and impaired neurodevelopmental processes during pregnancy and neuropsychological diseases such as PD, behavioral alterations, seizures and autism.

TL;DR: A comprehensive study of chalcones, their therapeutic targets, structure activity relationships (SARs), mechanisms of actions (MOAs) have been discussed and may be helpful for (medicinal) chemists to design more potent, safe, selective and cost effective chalcone derivatives as potential cardiovascular agents.

TL;DR: The study demonstrated successful formulation of surface modified risperidone liposomes for nasal delivery with brain targeting potential and in vivo results showed that liposomal formulations provided enhanced brain exposure.

TL;DR: An update on additional new therapeutic applications of glucosamine including treatment of cardiovascular disease, neurological deficits, skin disorders, cancer and the molecular mechanistic rationale for these uses is presented.

TL;DR: These outcomes indicated that SA pretreatment mitigates renal impairment and structural injuries via the downregulation of oxidative/nitrosative stress, inflammation, and apoptosis in the kidney.

TL;DR: In the exercise-trained rats, NRG1 expression was up-regulated and ErbB/PI3K/Akt signaling was activated compared with the MI group, and ET preserved heart function accompanied with increased numbers of BrdU(+) CMs, PCNA(+ CMs and c-kit(+) cells, and reduced apoptosis level in the MI rats.

TL;DR: The findings demonstrate the potential anti-inflammatory effect of ferulic acid on MSU crystal-induced inflammation in rats and show significant ligand efficiency towards pro-caspase-1, NF-κB, PYCARD/ASC, and NLRP3.

TL;DR: Evaluated data evidenced that isoquercitrin protected liver from APAP induced injury though inhibition of oxidative stress, nitrosative stress and inflammation, as well as regulation of APAP metabolism, suggesting that isquerc itrin could be a potential hepatoprotective agent.