Showing papers in "Life Sciences in 2017"

TL;DR: The machinery of Autophagy, the molecular web that connects autophagy to various stress responses like inflammation, hypoxia, ER stress, and various other pathologic conditions is discussed.

TL;DR: Countermeasures to the effects of ALAN, such as melatonin, bright light, or psychotropic drugs, have been proposed as a means to combat circadian clock disruption and improve adaptation to shift and night work.

TL;DR: The main aim of the present review is to evaluate and discuss the role of TNF‐&agr; in different metabolic alterations and muscle wasting in cancer cachexia.

TL;DR: How the multiple functions of NCL are correlated to its multiple cellular distributions is described, which makes NCL a potential target for the development of anti‐tumor and anti‐viral strategies.

TL;DR: In this article, a review aimed to show the association between neurodegenerative diseases, focusing on AD and PD, and metabolic alterations, and showed that metabolic changes caused by overweight are related to damage to the central nervous system (CNS).

TL;DR: Exposure to NPs may modulate ER stress, which could be a target for future nanotoxicological and nanomedicinal studies.

TL;DR: The present review renders a concise overview of the mechanism associated with doxorubicin-induced cardiotoxicity as well as giving insight into the role plant-derived phytochemical play as a possible adjunctive therapy against the development of doxOrubicIn-inducedCardiotoxicity.

TL;DR: A comprehensive survey of dysregulated lncRNAs in HCC is provided, with particular focus on the functions and regulatory mechanisms of several essential and important lnc RNAs, and their potential clinical application as early diagnostic and/or prognostic biomarkers or therapeutic targets for HCC are discussed.

TL;DR: The functions of CD133 in CSCs are introduced and summarized and new mechanisms that may be of note in the approach to developing novel cancer therapies are suggested.

TL;DR: This review aims to show the association between neurodegenerative diseases, focusing on AD and PD, and metabolic alterations, and shows a strong correlation between obesity and the development of Alzheimer's disease and Parkinson's disease.

TL;DR: FTY720 exerts both a direct protection for neurons and an indirect modulation of inflammation‐mediated neuron loss as a possible mechanism of neuroprotection in VPA‐exposed rats.

TL;DR: HIIT contribute a more favorable regulation of metabolic dysfunctions in DIO mice compared with MICT, which ameliorated adiposity and related metabolic dysfunction induced by HFD and sedentary lifestyle.

TL;DR: Administration of ACE2 attenuates Doxorubicin‐induced cardiac dysfunction via preservation of cardiomyocytes autophagy in a miR‐30e/beclin‐1 signal pathway and was confirmed by in vivo DHC rat experiments that showed that co‐injected ACE2 and miR•30 inhibitor reduced cardiac function.

TL;DR: The present mini review has focused on the potential mechanisms by which indoxyl sulfate exerts this pro‐oxidant effects on the cardiovascular system, and future therapeutic options are discussed, including modulating gut microbial flora and blocking responsible pathophysiologic pathways.

TL;DR: The functions and potential signaling pathways of Arf6 in tumor cells are concluded and an overview about clinical prospects of ArF6 in the screening, diagnosis, treatment and evaluation of prognosis of neoplasms is provided.

TL;DR: How miRNAs from small organisms especially those from Drosophila and C. elegans regulate development and disease pathogenesis is the focus of this review.

TL;DR: It is concluded that SRB contribute to immune response activation in the gut and play an important role in colitis development.

TL;DR: NR alleviated experimental liver fibrosis through inhibition of PI3K/Akt pathway beside its anti‐inflammatory and antioxidant effects, and is a promising therapeutic candidate for hepatic fibrosis.

TL;DR: The purpose of this review is to provide information regarding the potential benefits of melatonin as a co‐adjuvant treatment in gastrointestinal diseases, especially IBS, Crohn's disease, ulcerative colitis, and necrotizing enterocolitis.

TL;DR: It is demonstrated that aucubin shows protective effect against ethanol‐induced acute gastric mucosal injury through its anti‐inflammatory and anti‐oxidant effects.

TL;DR: Taurine seems to ameliorate obesity through stimulation of energy expenditure, modulation of lipid metabolism, anorexic effect, anti‐inflammatory and anti‐oxidative effects.

TL;DR: Ghrelin protected the heart against I/R injury by inhibiting oxidative stress and inflammation via TLR4/NLRP3 signaling pathway, and might provide new strategy and target for treatment of myocardial ischemia/reperfusion injury.

TL;DR: The data suggest that the inflammatory regulation, SDF‐1/CXCR4 and cellular apoptosis in ovarian tissues are involved in the development of ovarian injury of POF.

TL;DR: Both AMPK dependent and AMPK independent mechanisms involved in anticancer activity of metformin are reviewed along with the outcome of preclinical and clinical studies.

TL;DR: Overexpression miR‐532 promoted gastric cancer cell migration and invasion through inhibiting NKD1 and activated Wnt/&bgr;‐catenin pathway.

TL;DR: This research suggests that miR424‐5p may act as a novel anti‐oncogene in cervical cancer by blocking cell growth through targeting KDM5B‐Notch pathway.

TL;DR: Main measurements of material stiffness under different condition are summarized, three main methods of controlling stiffness which interplay with one another and correlate with stiffness positively are compared, and current advances in effects of biomaterial stiffness on stem cell fate are discussed.

TL;DR: The role of mast cells and histamine on cancer development and the possibility of use antihistamines in the clinical management of this disease are reviewed.

TL;DR: Ferulic acid at doses of 75 and 100 mg/kg significantly reduced the seizure score, number of myoclonic jerks, cognitive decline and oxidative stress, and appears as a promising adjuvant for antiepileptic drugs.

TL;DR: The present review highlights the recent trends and advancements have been done in the field of research by using carnosol.