Showing papers in "Life Sciences in 2019"

TL;DR: The present review summarizes structure, function, and different mechanisms GRP78 mediate in response to normal or stress conditions aiming to prevent the virulence of pathogens and cancer.

TL;DR: Preclinical research may provide powerful tools to quest the potential therapeutic and neuroprotective compounds for dopaminergic neurons and hence possible cure for the Parkinson's disease.

TL;DR: The aim of the present review is to shed light on the general role of MMPs, with special emphasis on MMP-13, in the induction of OA and the general basis of OB treatment, and selective inhibition of M MP-13 seems to be an attractive therapeutic strategy.

TL;DR: This review is aimed to discuss main (intrinsic and extrinsic) mechanisms of CSC resistance and suggest some strategies to revoke this important promoter of therapy failure.

TL;DR: Several mitochondria targeted strategies, such as enhancing the antioxidant bioavailability via novel delivery systems, identifying unique mitochondrial proteins as specific drug targets, investigating the signaling pathways of mitochondrial biogenesis and dynamics, and identifying effective natural products are potentially effective to counteract mitochondrial dysfunction‐related NDs.

TL;DR: The aim of the present review was to elaborate on the cellular and molecular mechanisms of the quercetin involved in the protection against AD.

TL;DR: The fact that metabolites of CP are responsible for cardiotoxicity due to depletion of antioxidants/ATP level, altered contractility, damaged endothelium and enhanced pro‐inflammatory/pro‐apoptotic activities resulting into cardiomyopathy, myocardial infarction, and heart failure is supported.

TL;DR: Carvacrol provides protection for hippocampal neurons against I/R in gerbils by inhibiting ferroptosis through increasing the expression of glutathione peroxidase 4(GPx4).

TL;DR: The execution of the CRISPR-Cas9 system has amplified the number of accessible scientific substitutes for studying gene function, thus enabling generation of CRISpr-based disease models and increasing understanding to disease processes and their treatment in the near future.

TL;DR: The main symptoms of PCOS are reviewed, including neuroendocrine disorders, reproductive processes, dyslipidemia, obesity, hypertension, nonalcoholic fatty liver disease (NAFLD), and sleep disordered breathing, which seriously affect the physical and mental health ofPCOS women.

TL;DR: Evidence suggests that mesenchymal stem cells-derived exosome (MSC-EXO) exhibit functions similar to MSCs with low immunogenicity and no tumorization, which has frequently been used in regenerative medicine and various diseases treatment compared to the other MSC- EXO resources.

TL;DR: Understanding the molecular and cellular mechanisms of tumor heterogeneity that are relevant to the development of treatment resistance is a major area of research and identification of differences between populations and their response to anticancer drugs would help to predict the potential resistance to chemotherapy and thus to select the most suitable anticancer treatment.

TL;DR: In this review, the scientific studies are being reported emphasizing benefits and its allied health claims on chrysin in numerous metabolic malfunctions.

TL;DR: Long non-coding RNA MALAT1 sponged miR-195 to regulate proliferation, apoptosis and migration and immune escape abilities of DLBCL by regulation of PD-L1.

TL;DR: This study shed new light on the potential application of miRNA-181a-overexpressing MSC-EXO as a therapeutic strategy for myocardial I/R injury and provided substantial coverage against a host of immune-related genes through the mi RNA-mRNA network.

TL;DR: The present review briefs the current treatments in terms of drugs used and in detail the impact of utilizing the above mentioned novel drug delivery systems in the treatment of glaucoma.

TL;DR: The latest research involving the lncRNA/circRNA-miRNA-mRNA axis in CVDs, with emphasis on the molecular mechanism, is summarized.

TL;DR: Melatonin through modulation of several apoptosis mediators such as mitochondria, Bax, Bcl-2, endogenous ROS, and apoptosis receptors facilitate apoptosis.

TL;DR: Fisetin attenuated the development of DCM via amelioration of hyperglycemia/hyperlipidemia‐mediated oxidative stress, inflammation and apoptosis in the diabetic heart through suppression of oxidative stress and boosted antioxidant defenses in the heart of diabetic rats.

TL;DR: Chitosan-2% w/v bromelain nanofiber possesses great wound healing activity and could be considered as an effective natural topical burn wound healing treatment.

TL;DR: This review aims to clarify the pharmacological activity of CBD and its multiple therapeutic applications and critical and conflicting results of the research are discussed with a focus on promising future prospects.

TL;DR: SNHG16 regulated LPS-induced inflammation injury in WI-38 cells through competitively binding miR-146a-5p with CCL5 further mediating JNK and NF-κB pathways, which sheds novel light on diagnostics and therapeutics in pneumonia.

TL;DR: Toxicity evaluation is a critical point in the development of nanoformulations and therefore, draws considerable attention and might be evaluated further for safety related issues considering future medications based on MNPs.

TL;DR: It is found that melatonin protected against sepsis‐induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice.

TL;DR: The study indicated that AS-IV could promote angiogenesis and cardioprotection after myocardial infarction and the mechanisms involve activation of PTEN/PI3K/Akt signaling pathway.

TL;DR: It is demonstrated that polydatin may protect the spinal cord from SCI by suppression of oxidative stress and apoptosis via improving Nrf2/HO‐1 signaling in microglia.

TL;DR: In this paper, the authors describe mtDNA alterations during liver injury, focusing on the mechanisms of mtDNA-mediated liver inflammation and oxidative stress injury and further exacerbate hepatocellular damage and even remote organs injury.

TL;DR: The scopolamine-induced cellular and molecular changes are reviewed and how these changes relate to AD pathogenesis are discussed.

TL;DR: Knockdown of circ_0076305 might provide an effective approach for NSCLC treatment strategy, and the role and molecular mechanism in regulating cisplatin resistance of non-small cell lung cancer was investigated.

TL;DR: Hispidulin is a neuroprotective agent with clinical potential against IR-induced neurological injury by suppressing NLRP3-mediated pyroptosis by modulating the AMPK/GSK3β signaling pathway.