Showing papers in "Life Sciences in 2020"

TL;DR: The results suggest the effectiveness of Ribavirin, Remdesivir, Sofosbuvir, Galides Vivir, and Tenofovir as potent drugs against SARS-CoV-2 since they tightly bind to its RdRp.

TL;DR: The results suggest the effectiveness of Sofosbuvir, IDX-184, Ribavirin, and Remidisvir as potent drugs against the newly emerged HCoV disease.

TL;DR: Melatonin, a well-known anti-inflammatory and anti-oxidative molecule, is protective against ALI/ARDS caused by viral and other pathogens and might also be beneficial for better clinical outcomes for COVID-19 patients.

TL;DR: In this article, a systematic review of the literature was carried out to identify relevant articles using six different databases, including COVID-19, SARS-CoV2, and Biomarkers.

TL;DR: Myocardial injury is one of the important pathogenic features of COVID-19, and multiple studies have shown increased cardiac biomarkers mainly cardiac troponins I and T in the infected patients especially those with severe disease.

TL;DR: In this paper, drug repurposing is the concept of identifying therapeutically potent molecule from the library of pre-existing molecules for treating corona virus disease, which is a commonly used technique in drug discovery.

TL;DR: The present study provided a comprehensive targeting of the first resolved COVID+19 structure of Mpro and found a suitable save drugs for repurposing against the viral Mpro in a virtual screening study by of FDA approved drugs dataset.

TL;DR: The monocytes and macrophages responses during severe coronavirus infections are described, while potential therapeutic interventions to attenuate macrophage-related inflammatory reactions in possible approaches for COVID-19 treatment are highlighted.

TL;DR: A literature review was performed to identify relevant articles on COVID-19 published up to April 30, 2020 and found evidence of a hyper-inflammatory immune response in critically ill patients, which leads to acute respiratory distress syndrome (ARDS) and multi-organ failure.

TL;DR: The comorbidities and multi-organ failure of COVID-19 have been explained at a molecular level along with the base of the SARS- coV and MERS-CoV.

TL;DR: Targeting LPC and lipid metabolism might be a potential therapeutic method for inflammation-related diseases.

TL;DR: This review study has aimed to identify what has revealed the critical properties of Qu such as anti-inflammatory, anti-oxidant, and even its effect on proliferation, angiogenesis, or apoptosis that are considered asAnti-tumor property to enhance breast cancer treatment.

TL;DR: Deep insight into the sophisticated structure of SARS-CoV-2 S protein may provide a blueprint for vaccination strategies, as reviewed herein.

TL;DR: A better understanding of the mechanisms of lncRNA/microRNA interactions in angiogenesis may provide helpful insights and shed new light on areas of research for identifying diagnostic markers and therapeutic approaches for treatingAngiogenesis-related diseases.

TL;DR: Decrease in total lymphocytes and lymphocyte subsets as well as the elevation of CRP, ESR, SAA, PCT, ferritin, and cytokines, but not IL-1β and IL-17, were closely associated with COVID-19 severity, implying reliable indicators of severe CO VID-19.

TL;DR: This review focused on the role of this pathway in gastric cancer development, prognosis, and metastasis, with an emphasis on epigenetic alterations including DNA methylation, histone modifications, and post-transcriptional modulations through non-coding RNAs fluctuations as well as H. pylori and Epstein-Barr virus infections.

TL;DR: Data demonstrating the role of CREB-BDNF signaling pathway in cognitive status and mediation of Aβ toxicity in AD is summarized and the developing intervention methods for improvement of cognitive decline in AD based on targeting ofCREB- BDNF pathway are focused on.

TL;DR: PVT1 regulated ferroptosis through miR-214-mediated TFR1 and TP53 expression and counteracted the effects of PVT1 knockdown on the ferroPTosis-related proteins.

TL;DR: The latest research progress in the strategies of treatments that mainly focus on reducing the Ang II-induced deleterious effects rather than attenuating the virus replication are summarized.

TL;DR: Increased oxidative stress underlies the decrease in antioxidant capacities and mitochondrial dysfunction in HG environment correlate with inflammation response and apoptosis via ERK1/2-PI3K/Akt-IRF3 pathway in keratinoctes.

TL;DR: Bonducellpin D exhibited broad-spectrum inhibition potential against SARS- CoV Mpro and MERS-CoV M Pro and therefore is a promising drug candidate, which needs further validations through in vitro and in vivo studies.

TL;DR: The renin-angiotensin system exaltation with consequent inflammatory response has a leading role in the physiopathology of COVID-19 infection; and it may be down-regulated by vitamin D and melatonin in many organs, so it is also essential to analyze this potential therapeutic association and their relation with RAS as part of this new approach.

TL;DR: The current understanding of the molecular mechanisms involved in pyroptosis, as well as recent advances in the role of NLRP3 inflammasome activation and pyroPTosis in the development of diabetes and diabetic complications are summarized.

TL;DR: Certain substances such as extracts from medicinal plants, natural products, and chemical substances have been shown to produce an alleviating effect against the doxorubicin-induced hepatotoxicity are also discussed.

TL;DR: MUC1 aptamer-decorated exosomes can be implemented therapeutically for the safe and versatile delivery of DOX to colon adenocarcinoma, thus offering valuable platform for clinical applications.

TL;DR: The present review describes the novel SARS-CoV-2 structure, surface proteins, asymptomatic and symptomatic transmission in addition to the genotype and phenotype of Sars-Cov-2 along with genetic strains and similarity between SARS, MERS and SARS

TL;DR: A comprehensive approach to understanding AD is presented and suggestions to be considered in the development of therapeutics for it are considered.

TL;DR: This review will provide an insight into the extracellular miRNAs, particularly, their release mechanisms and characteristics, and the potential of ext racellular mi RNAs as a biomarker in cancer detection.

TL;DR: The emerging progress in the applications of exosomes in the form of free or association with hydrogels as therapeutic agents for applications in regenerative medicine is critically reviewed.

TL;DR: The concept behind this review is to underscore the multi-tasking roles taken by CXCL12/CXCR4 signaling in tumor metastasis, and to also suggest some strategies to target the activities within this axis.