Showing papers in "Life Sciences in 2022"

TL;DR: In this article, the authors provide a panoramic view of ALS, which includes epidemiology, risk factors, pathophysiologies, biomarkers, diagnosis, therapeutics (natural, synthetic, gene-based, pharmacological, stem cell, extracellular vesicles, and physical therapy), controversies (in the clinical trials of ALS), the scope of nanomedicine in ALS, and future perspectives.

TL;DR: In this paper, a selective culture medium for lactate-utilizing bacteria (LUB) that function as candidate probiotics to ameliorate IBD using a mouse model was developed.

TL;DR: In this paper, superparamagnetic iron oxide (SPION) nanoparticles were covered by chitosan lactate (CL), functionalized with TAT peptide, and finally these NPs were loaded with siRNA molecules against PD-1 and A2aR.

TL;DR: In this article, the role of tumor acidification in cell behavior, migration, and treatment resistance of oral squamous cell carcinoma (OSCC) was investigated, where the SCC4 and SCC25 cell lines were exposed to acidified (pH 6.8) cell culture medium for 7 days, and a long-term acidosis was induced for 21 days.

TL;DR: Wang et al. as discussed by the authors showed that miR-125a-5p could inhibit LPS-induced acute inflammation in the kidney through targeting TRAF6/NF-κB axis.

TL;DR: In this paper, the authors investigated the effect of aloin against the isoproterenol (ISO)-induced cardiac hypertrophy in rats and found that aloin markedly alleviated ISO-induced heart injury, reduced cardiac hyper-trophy, improved cardiac function, and histological alterations in the heart.

TL;DR: In this paper, a rat chronic periodontitis (CP) model was constructed through dental silk ligation, and the corresponding inflammatory reactions and fatty lesions were observed in the liver.

TL;DR: Kozlova et al. as discussed by the authors characterized neuroinflammatory and gut dysbiosis signatures that accompany exaggerated exercise fatigue and cognitive/mood deficits in a mouse model of Gulf War Illness.

TL;DR: In this paper, the effects of IL-9 on macrophage-related inflammatory response and hepatocyte apoptosis in alcohol-induced liver injury by injecting adeno-associated virus (AAV9) into tail vein were investigated.

TL;DR: In this paper, the authors evaluated the antifibrotic effect of everolimus against tacrolimus-induced kidney fibrosis in male Wistar rats and found that it attenuated kidney interstitial fibrosis and associated abnormalities.

TL;DR: In this article, the effects of intravenous lecithinized superoxide dismutase (PC-SOD) administration in a mouse model of renal injury induced by I/R were evaluated.

TL;DR: In this article, the effects of ACE2 activator xanthenone on tacrolimus-induced renal injury were investigated in male Wistar rats, where the ACE2 activation was associated with angiotensin-converting enzyme 2 (ACE2) degradation.

TL;DR: In this article, the authors investigated sex differences in heat-induced mitochondrial dysfunction, ROS production, and skeletal muscle injury in mice, and evaluated whether curcumin and astaxanthin, alone or together, would prevent those heatinduced changes.

TL;DR: In this article, the influence of triphenylphosphonium (TPP)-based compounds SkQ1 and C12TPP on FceRI-dependent mitochondrial dysfunction and signaling during MC degranulation was investigated.

TL;DR: In this article, a pre-adipocyte cell line was differentiated into mature adipocytes with either vehicle or various obesogens, including bisphenol A, tolylfluanid, and endrin, as well as corticosterone, at the same dose.

TL;DR: In this paper, the authors evaluated the potential pharmacological mechanism of veratramine in glioma using four types of human glioblastoma cell lines, including A172, HS-683, T98G, and U-373-MG.

TL;DR: In this paper, the role of platelet-derived growth factor receptors (PDGFRs) in cancer progression was examined in androgen-independent prostate cancer PC-3 cells.

TL;DR: The Phenethyl ester of RA (PERA), a novel RA derivative, has been developed and evaluated in vivo in an animal model of type 1 diabetes (T1D) using multiple low doses of streptozotocin (STZ) administered intraperitoneally for 5 consecutive days.

TL;DR: In this paper, the effect of palmitoylation on the sodium hydrogen exchanger isoform 1 (NHE1), a member of the SLC9 family, was evaluated by acyl-biotinyl exchange (ABE) and metabolic labeling with [3H]palmitate.

TL;DR: In this article, the effects of interferon (IFN)-α on triggering and regulating autoimmune thyroiditis in various animal models were evaluated, and the remarkable effects of IFN-α in both initiating thyroid immunity and modulating thyroid function and immunoregulatory signatures were confirmed.

TL;DR: In this article, the changes in large-conductance Ca2+-activated K+ (BKCa) channels from human umbilical arterial smooth muscle cells experiencing gestational diabetes mellitus (GDM) were investigated.

TL;DR: In this article, a 3D-model of human ADA3 was proposed and domains involved in the oncogenic interaction between hADA3 and HPV16E6 were delineated.

TL;DR: In this article, a review of the current level of understanding of neurological repair after stroke, with the main focus on the mechanism of axonal sprouting, is presented, along with potential ways of imaging them in rodents.