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Showing papers in "Lung Cancer in 2011"


Journal ArticleDOI
TL;DR: Resistance to current chemotherapeutics available for the management of non-small cell lung cancer (NSCLC) represents one of the most significant barriers to improving long-term outcomes for this vulnerable patient group.

378 citations


Journal ArticleDOI
TL;DR: A ten-session preoperative PR intervention may improve post operative lung reexpansion evidenced by shorter chest tube times and decrease the length of hospital stay and a crude estimator of post operative morbidity and costs is suggested.

214 citations


Journal ArticleDOI
TL;DR: Additional exercise and strength training after lung resection successfully prevented the fall in quadriceps strength seen in controls, however, there was no effect on 6MWD or QoL.

181 citations


Journal ArticleDOI
TL;DR: Exercise intervention for patients with NSCLC is safe before and after cancer treatment, and interventions pre-operatively or post-cancer treatment are associated with positive benefits on exercise capacity, symptoms and some domains of HRQoL.

178 citations


Journal ArticleDOI
TL;DR: It is demonstrated that changes in metabolite pattern are useful for assessing the clinical characteristics of lung cancer and will hopefully lead to the establishment of novel diagnostic tools.

167 citations


Journal ArticleDOI
TL;DR: It was demonstrated that those up-regulated genes in TAMs contributed to suitable microenvironments for lung cancer invasion and metastasis, and may be useful in developing novel therapeutic strategies to prevent lung cancer progression.

160 citations


Journal ArticleDOI
TL;DR: It is found that EMT developed in a lung cancer patient who had an acquired resistance to erlotinib while there were no known resistant mechanisms such as T790M and MET amplification.

155 citations


Journal ArticleDOI
TL;DR: Her2 mutations are present in a subset of patients with lung cancer having distinct clinical features and might benefit from anti-HER2 therapy, and were not associated with the prognosis of Patients with lung cancers.

132 citations


Journal ArticleDOI
TL;DR: Although smoking is the dominant risk factor of lung cancer, XPA -4G>A (rs1800975) is also associated with the risk of NSCLC, especially for squamous cell carcinoma, among Asian young smokers and the NER pathway seems to have more strong influences on lung cancer than the BER pathway.

129 citations


Journal ArticleDOI
TL;DR: Inhibiting JAK2 and knocking down STAT3 both suppressed STAT3 activation and reduced the expression of VEGF and bFGF in A549 and NCI-H292 cells, demonstrating thatSTAT3 activation was associated with VEGf and b FGF expression in the two human lung carcinoma cell lines.

128 citations


Journal ArticleDOI
TL;DR: It is proposed that a surgical philosophy of limiting the procedure related morbidity while achieving comparable cytoreductive results allows patients to maintain physiological reserve to be eligible for multimodality treatment options in the long-term.

Journal ArticleDOI
TL;DR: Stronger HDAC1 expression by tumor cells is an independent predictor of a poor prognosis in patients with adenocarcinoma of the lung.

Journal ArticleDOI
TL;DR: In patients selected for the presence of tumor harbouring EGFR mutation, the administration of first-line gefitinib, as compared to standard chemotherapy, was associated with longer progression-free survival, higher objective response rate, a more favourable toxicity profile and better quality of life.

Journal ArticleDOI
TL;DR: A positive EGFR result in plasma DNA has a high predictive value for tumor EGFR status and for favorable clinical course on EGFR-targeted therapy and could therefore be useful in guiding clinical decisions in patients with insufficient or unavailable tumor specimens.

Journal ArticleDOI
TL;DR: Re-treatment with PBC should be considered as second-line therapy in MPM patients achieving a durable (>12 months) disease control with first-line PBC.

Journal ArticleDOI
TL;DR: This is the first report indicating that advanced NSCLC patients with IIP may benefit from chemotherapy, and weekly paclitaxel and carboplatin combination chemotherapy was as effective as conventional regimens in advanced NSclC patients without IIP and was safer than previously reported.

Journal ArticleDOI
TL;DR: A case of a patient with a concomitant EGFR mutation and ALK translocation resistant to erlotinib is reported, suggesting ALK status should be investigated in unexplained cases of EGFR-TKI-resistance of EG FR mutated NSCLCs.

Journal ArticleDOI
TL;DR: KIF23 not only provides additional prognostic information for surgical treatment of lung cancer, but may also be a novel therapeutic target for these patients.

Journal ArticleDOI
TL;DR: The results suggest that Nos enhanced the anticancer activity of Cis in an additive to synergistic manner by activating multiple signaling pathways including apoptosis and suggest potential benefit for use of Nos and Cis combination in treatment of lung cancer.

Journal ArticleDOI
TL;DR: The characteristic histology, immunoprofile, frequent ALK translocation, and total lack of EGFR or KRAS mutations, may suggest that Ad-SRCC forms a histologically/molecularly coherent subgroup of adenocarcinoma.

Journal ArticleDOI
TL;DR: 12 differently expressed miRNAs were found in the radiotherapy sensitive and resistant non-small cell lung cancer samples and results showed miRNA-126 promoted non- Small Cell lung cancer cells apoptosis induced by irradiation through the PI3K-Akt pathway.

Journal ArticleDOI
TL;DR: This review hypothesizes a novel scenario for the progression of lung adenocarcinoma, which does not support a linear progression schema and some clinical observations that support that some lesions escape from the progression.

Journal ArticleDOI
TL;DR: TS expression, rather than DHFR, may be an important predictive factor for treatment efficacy of pemetrexed in NSCLC patients and the association of DHFR expression level and median PFS as well as OS were not statistically significant.

Journal ArticleDOI
TL;DR: It is shown that blood miRNA signatures are suitable to distinguish lung cancer from COPD.

Journal ArticleDOI
TL;DR: Findings indicate that a cluster of interacting respiratory symptoms play a central role in patients' symptom experiences within the lung cancer population.

Journal ArticleDOI
TL;DR: Oral icotinib was generally well tolerated, with manageable and reversible adverse events (AEs) and showed positive clinical anti-tumor activities in patients with advanced NSCLC.

Journal ArticleDOI
TL;DR: In this paper, Telomere length plays an important role in chromosomal stability and tumorigenesis, and its measurement in peripheral white blood cell DNA may be a predictor of the development of lung cancer.

Journal ArticleDOI
TL;DR: Surgical resection of primary salivary gland-type lung cancer was an effective treatment with low operative morbidity, and expected long-term survival, and Repeated surgical resection may be considered aneffective treatment modality in some cases of recurrence.

Journal ArticleDOI
TL;DR: In this article, the status of the EGFR and K-ras genes were investigated by PCR-based analyses, and the expression of HGF, PTEN, and EGR-1, and changes in the epithelial-mesenchymal transition (EMT) status were evaluated by immunohistochemistry.

Journal ArticleDOI
TL;DR: Adenocarcinoma, tumors located in the upper or middle lobe, tumor size >3 cm, and SUV(max) of primary tumor >4.0 g/ml are risk factors for occult MLN metastasis in patients with NSCLC who were diagnosed as clinical N0-1 by preoperative integrated FDG-PET/CT and CT.