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JournalISSN: 0074-0276

Memorias Do Instituto Oswaldo Cruz 

Instituto Oswaldo Cruz, Ministério da Saúde
About: Memorias Do Instituto Oswaldo Cruz is an academic journal published by Instituto Oswaldo Cruz, Ministério da Saúde. The journal publishes majorly in the area(s): Population & Trypanosoma cruzi. It has an ISSN identifier of 0074-0276. It is also open access. Over the lifetime, 7854 publications have been published receiving 174136 citations. The journal is also known as: Proceedings of the Instituto Oswaldo Cruz.


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Journal ArticleDOI
TL;DR: Ao terminar, cumprimos o grato dever de afirmar o maior reconhecimento ao nosso mestre e Diretor Dr. Goncalves Cruz, a cuja orientacao devemos o rezultado destas pesquizas.
Abstract: 1o O Schizotrypanum cruzi apresenta, no organismo do conorrino, duas modalidades de desenvolvimento, reprezentando a primeira simples cultura do parazito; a outra, provavelmente precedida de fenomenos sexuais nao surpreendidos, sera, talvez, o ciclo evolutivo, eficaz na transmissao entre os vertebrados. 2o O Conorhinus e um verdadeiro hospede intermediario do Schizotrypanum, cujo ciclo e realizado num prazo minimo de 8 dias. 3o Os flajelados, com tipo de critidias encontrados nos conorrinos em liberdade, podem reprezentar estadios culturais do Schizotrypanum ou serao parazitos excluzivos do inseto. 4o A ocurrencia do ciclo evolutivo sexuado, no organismo do conorrino, depende de condicao nao explicada, dos flajelados no sangue dos vertebrados. Ao terminar, cumprimos o grato dever de afirmar o maior reconhecimento ao nosso mestre e Diretor Dr. Goncalves Cruz, a cuja orientacao devemos o rezultado destas pesquizas. Somos ainda profundamente grato aos nosso mestres, Professores S. von PROWAZEK e M. HARTMANN, de quem recebemos os melhores ensinamentos para concluzao deste trabalho. Tambem somos em extremo obrigado ao Dr. ADOLPHO LUTZ, cujo auxilio nos foi do mais alto proveito. Tivemos sempre, como esforcado companheiro de trabalho na zona infestada pela nova especie morbida, o Dr. BELISARIO PENNA, a quem devemos os inestimaveis proveitos de um auxilio eficaz.

1,292 citations

Journal ArticleDOI
TL;DR: Phylogenetic analysis suggests that the ZikV identified belongs to the Asian clade, the first report of ZIKV infection in Brazil, and the result was confirmed by DNA sequencing.
Abstract: In the early 2015, several cases of patients presenting symptoms of mild fever, rash, conjunctivitis and arthralgia were reported in the northeastern Brazil. Although all patients lived in a dengue endemic area, molecular and serological diagnosis for dengue resulted negative. Chikungunya virus infection was also discarded. Subsequently, Zika virus (ZIKV) was detected by reverse transcription-polymerase chain reaction from the sera of eight patients and the result was confirmed by DNA sequencing. Phylogenetic analysis suggests that the ZIKV identified belongs to the Asian clade. This is the first report of ZIKV infection in Brazil.

1,047 citations

Journal ArticleDOI
TL;DR: In an effort to unify the nomenclature of Trypanosoma cruzi, the causative agent of Chagas disease, an updated system was agreed upon at the Second Satellite Meeting that T. cruzi strains should be referred to by six discrete typing units.
Abstract: In an effort to unify the nomenclature of Trypanosoma cruzi, the causative agent of Chagas disease, an updated system was agreed upon at the Second Satellite Meeting. A consensus was reached that T. cruzi strains should be referred to by six discrete typing units (T. cruzi I-VI). The goal of a unified nomenclature is to improve communication within the scientific community involved in T. cruzi research. The justification and implications will be presented in a subsequent detailed report.

900 citations

Journal ArticleDOI
TL;DR: Five of the Brazilian medicinal plants screened for their antimicrobial activity against bacteria and yeasts presented compounds with Rf values similar to the antibacterial compounds visible on bioautogram, which may mean that the same compounds are responsible for the antib bacterial activity in these plants.
Abstract: Extracts of 13 Brazilian medicinal plants were screened for their antimicrobial activity against bacteria and yeasts. Of these, 10 plant extracts showed varied levels of antibacterial activity. Piper regnellii presented a good activity against Staphylococus aureus and Bacillus subtilis, a moderate activity on Pseudomonas aeruginosa, and a weak activity against Escherichia coli. Punica granatum showed good activity on S. aureus and was inactive against the other standard strains. Eugenia uniflora presented moderate activity on both S. aureus and E. coli. Psidium guajava,Tanacetum vulgare, Arctium lappa, Mikania glomerata, Sambucus canadensis, Plantago major and Erythrina speciosa presented some degree of antibacterial activity. Spilanthes acmella, Lippia alba, and Achillea millefolium were considered inactive. Five of the plant extracts presented compounds with Rf values similar to the antibacterial compounds visible on bioautogram. Of these, three plants belong to the Asteraceae family. This may mean that the same compounds are responsible for the antibacterial activity in these plants. Anticandidal activity was detected in nine plant extracts (P. guajava, E. uniflora, P. granatum, A. lappa, T. vulgare, M. glomerata, L. alba, P. regnellii, and P. major). The results might explain the ethnobotanical use of the studied species for the treatment of various infectious diseases.

839 citations

Journal ArticleDOI
TL;DR: A historical introduction of drugs assayed against Chagas disease beginning in 1912 with the works of Mayer and Rocha Lima up to the experimental use of nitrofurazone, and a survey about new classes of synthetic and natural compounds studied after 1992/1993.
Abstract: In this "Critical Review" we made a historical introduction of drugs assayed against Chagas disease beginning in 1912 with the works of Mayer and Rocha Lima up to the experimental use of nitrofurazone. In the beginning of the 70s, nifurtimox and benznidazole were introduced for clinical treatment, but results showed a great variability and there is still a controversy about their use for chronic cases. After the introduction of these nitroheterocycles only a few compounds were assayed in chagasic patients. The great advances in vector control in the South Cone countries, and the demonstration of parasite in chronic patients indicated the urgency to discuss the etiologic treatment during this phase, reinforcing the need to find drugs with more efficacy and less toxicity. We also review potential targets in the parasite and present a survey about new classes of synthetic and natural compounds studied after 1992/1993, with which we intend to give to the reader a general view about experimental studies in the area of the chemotherapy of Chagas disease, complementing the previous papers of Brener (1979) and De Castro (1993).

822 citations

Performance
Metrics
No. of papers from the Journal in previous years
YearPapers
202337
2022104
202134
202096
201983
2018113