Showing papers in "Modern Pathology in 2013"

TL;DR: Recent data about the biological characteristics of lncRNAs in cancer pathways include examples with a wide range of molecular mechanisms involved in gene regulation, and the medical implications are considered.

TL;DR: Increasing contribution of modern pathology to broader public health sciences is illustrated, which attests pivotal roles of pathologists in the new integrated MPE science towards the ultimate goal of personalized medicine and prevention.

TL;DR: In this paper, the authors found that pleuroparenchymal fibroelastosis is a major histopathologic correlate of restrictive allograft syndrome, and was often found concurrently with diffuse alveolar damage.

TL;DR: The largest case series to date examining PLA2R1 involvement in membranous glomerulopathy is presented utilizing a technique that is readily adoptable by most renal pathology laboratories.

TL;DR: A pilot study showed that recurrence score can be predicted by an equation incorporating standard morphoimmunohistologic variables (referred to as original Magee equation) and if the estimated recurrence Score is clearly high or low, the oncologists should not expect a dramatically different result from Oncotypes DX, and the Oncotype DX test may not be needed.

TL;DR: It is suggested that ARID1A is a causative gene, instead of a target gene, of microsatellite instability by having a role in epigenetic silencing of the MLH1 gene in endometrial cancer.

TL;DR: It is demonstrated that the inter- and intraobserver reproducibility of histological type based on morphology alone are mostly moderate, and ancillary techniques such as immunohistochemical marker panels are likely needed to improve diagnostic reproducibles of Histological types within high-grade endometrial carcinomas.

TL;DR: Data indicate that the use of antibodies with high sensitivity and avidity to ALK may provide an effective pre-screening technique to complement the more expensive and labor-intensive approach of ALK FISH testing.

TL;DR: MAP3K7 deletion is identified as a prominent feature in ERG-negative prostate cancer with strong association to tumor aggressiveness and lacking evidence for inactivation through hypermethylation indicates MAP3k7 as a gene for which haploinsufficency is substantially tumorigenic.

TL;DR: It is found that KRAS-mutated carcinomas frequently develop in contiguity with a residual polyp and show molecular features distinct from other colorectal carcinomas, in particular from tumors with neither BRAF nor KRAS mutation.

TL;DR: Results suggest that, in methylator-positive tumors, mucin genes on chromosome 11p15.5 region undergo increased expression via mechanisms other than direct regulation by CDX2, and that there were inverse associations between expression of all four mucins and p53 overexpression.

TL;DR: Overall, these patients with non-mammary metastases involving the breast and/or axilla had poor survival; 96% of patients with follow-up available are dead of disease, with a median survival of 15 months after the diagnosis of the breast or axillary lesion.

TL;DR: SOX10 expression clearly delineated two distinct subtypes of human salivary gland tumors; acinic cell carcinomas, adenoid cystic carcinoma, epithelial-myoepithelial carcinomas and pleomorphic adenomas, including the pleomorphicAdenoma component of carcinoma were identified.

TL;DR: Future molecular studies and the combination of other fluid markers are required to improve the detection and classification of pancreatic mucinous neoplasms by endoscopic ultrasound fine-needle aspiration.

TL;DR: In early stage membranous glomerulonephritis, antibody response is different from later stages, with IgG1 dominant deposits, and it appears that there is an inverse relationship between the intensity of glomerular capillary IgG4 and C1q staining.

TL;DR: Loss of SDHA expression in GIST reliably predicts the presence ofSDHA mutations, which represent a relatively common cause of SDH-deficient GIST in adults.

TL;DR: Branched tubules, small papillae, and the immunohistochemical and molecular profiles aid in distinguishing these tumors from clear cell renal cell carcinoma and multilocular cystic renal cell cancer.

TL;DR: The results confirm the high frequency of SMARCB1 deletions in epithelioid sarcoma and show that multiplex ligation-dependent probe amplification is a reliable method for detection of deletion in these cases, which can be performed on formalin-fixed, paraffin-embedded tissue.

TL;DR: PTEN loss is identified as a potentially useful marker to distinguish intraductal carcinoma from PIN and provides a plausible molecular explanation for why intraductive carcinoma is associated with poor prognosis.

TL;DR: Using 10-high-power fields for evaluating tumor budding has independent prognostic value and shows excellent inter-observer agreement and like the BRE and Gleason scores in breast and prostate cancers, respectively, could be a basis for a prognostic score in colorectal cancer.

TL;DR: In this largest comprehensive study, 35% of endometrial serous carcinoma harbors HER2 protein overexpression and/or gene amplification, over half of which demonstrate significant heterogeneity of protein expression.

TL;DR: MET overexpression is an independent prognostic factor and could be a potential target and predictor of benefit for targeted therapy with MET inhibitors and developed highly correlating interpretation methods of MET immunohistochemistry in gastric carcinomas.

TL;DR: High-resolution array-based comparative genomic hybridization revealed that fusion-positive tumors had significantly fewer copy number alterations/tumor compared with fusion-negative tumors, and molecular genetic analysis can be a useful adjunct to histologic scoring of mucoepidermoid carcinoma.

TL;DR: The aim of this study was to identify the miRNA profile of well-differentiated small intestinal neuroendocrine tumors, which may have a critical role in tumor development, progression and potentially develop miRNAs as novel clinical biomarkers.

TL;DR: Prolonged exposure to low doses of Cd leads to high hepatic accumulation, which can then cause fibrosis; however, it also causes high expression of metallothionein, which is thought to reduce Cd hepatotoxicity.

TL;DR: The existence of positive pathology in surgical specimen may be a good indication for short-term good seizure outcome, and the heterogeneity of epileptic pathologies in MRI-negative epilepsies is highlighted.

TL;DR: Findings indicate that MED12 has oncogenic roles in a broad range of smooth muscle neoplasia, including tumors arising in extrauterine locations, as well as primary and metastatic leiomyosarcoma.

TL;DR: New data are emerging on the molecular pathogenesis of T-cell and NK-cell lymphoma, but most tumor types remain poorly characterized.

TL;DR: Extended molecular and clinicopathological analysis of lung adenocarcinomas reveals a novel association of KRAS mutations with solid histology and tumor-infiltrating inflammatory cells and expands on several previously recognized morphological and clinical associations of KRas and EGFR mutations.

TL;DR: The data show that the ALT and ATRX protein alterations are common in both pediatric and adult high-grade astrocytomas, often with associated PDGFRA gene amplification.