Showing papers in "Molecular and Cellular Biology in 1977"

In vivo--in vitro studies of the evolution of epithelial neoplasia

Abstract: The hypothesis of neoplastic development is that following initiating events, progressively changing cell populations emerge which possess an increasing propensity to acquire the biological properties of cancer cells. Morphologically and biochemically abnormal cells appear during the latency period which constitutes what are believed to be preneoplastic lesions. Evidence for this hypothesis is discussed. An experimental model for the study of incipient neoplasia is described with regard to an in vivo system for exposure to carcinogens and an in vitro system for analysis of cellular changes. In vivo-in vitro studies with the explant-outgrowth system and with dispersed epithelial cells are also described. The altered growth capacity of carcinogen-exposed cells is discussed. (HLW)