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JournalISSN: 1097-2765

Molecular Cell 

Elsevier BV
About: Molecular Cell is an academic journal published by Elsevier BV. The journal publishes majorly in the area(s): Chromatin & Biology. It has an ISSN identifier of 1097-2765. Over the lifetime, 8927 publications have been published receiving 1436757 citations. The journal is also known as: Mol Cell & Mol. Cell.

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Journal ArticleDOI
TL;DR: It is demonstrated in macrophages and B cells that collaborative interactions of the common factor PU.1 with small sets of macrophage- or B cell lineage-determining transcription factors establish cell-specific binding sites that are associated with the majority of promoter-distal H3K4me1-marked genomic regions.

9,620 citations

Journal ArticleDOI
TL;DR: In this article, the inflammasome is identified as a caspase-activating complex that comprises caspases-1, casp-5, Pycard/Asc, and NALP1, a Pyrin domain-containing protein sharing structural homology with NODs.

5,032 citations

Journal ArticleDOI
TL;DR: Five general features of site context that boost site efficacy are uncovered: AU-rich nucleotide composition near the site, proximity to sites for coexpressed miRNAs (which leads to cooperative action), proximity to residues pairing to miRNA nucleotides 13-16, positioning within the 3'UTR at least 15 nt from the stop codon, and positioning away from the center of long UTRs.

3,818 citations

Journal ArticleDOI
TL;DR: This review will focus on how the DDR controls DNA repair and the phenotypic consequences of defects in these critical regulatory functions in mammals.

3,678 citations

Journal ArticleDOI
TL;DR: These archetypes of lncRNA function may be a useful framework to consider how lncRNAs acquire properties as biological signal transducers and hint at their possible origins in evolution.

3,621 citations

No. of papers from the Journal in previous years