Showing papers in "Mutation Research Letters in 1990"

TL;DR: It is concluded that bone marrow cells can be replaced by peripheral blood as material for the micronucleus assay and the distinction between young and mature erythrocytes was clearer and less subjective.

TL;DR: The data suggest that both sulfation- and acetylation-dependent metabolic pathways may be important in the mammalian genotoxic actions of PhIP.

TL;DR: Results discussed in this study suggest that microwave radiation causes changes in the synthesis as well as in the structure of DNA molecules.

TL;DR: An aqueous solution of calf thymus DNA was irradiated by 60Co gamma-rays and modified nucleosides produced in DNA were analyzed by high-pressure liquid chromatography coupled with a photodiode array UV detector and a new product with UV absorption maxima at 230 nm and 280 nm was observed.

TL;DR: The micronucleus (MN) assay was applied to exfoliated cells of buccal and nasal cavities to monitor the genotoxic risk in a group of workers exposed to chromic acid and in another group exposed to ethylene oxide (EtO).

TL;DR: It was shown that the observed joint effect was significantly higher than additive interaction, and was close to multiplicative interaction, bringing further support to the hypothesis that the toxic and genotoxic effects of benzene are produced by several metabolites acting synergistically.

TL;DR: The results support those published by Tuschl et al. (1980, 1983) and Liu et al (1987), showing that it is possible to induce the adaptive response in vivo.

TL;DR: Findings indicate that the micronucleus test not only detects chemicals affecting microtubule assembly, but also can discriminate them from clastogens by measurements of the area of the micronsuclei.

TL;DR: The data suggest that carriers of splice mutations often do not show the characteristics of HPRTase deficiency associated with these genetic diseases, because correctly spliced hprt mRNA is still produced at a low level.

TL;DR: X-ray-induced chromosome aberrations were suppressed when vanillin, cinnamaldehyde, or p-anisaldehyde was given orally to mice after X-ray irradiation without toxicity of the test compounds to the bone marrow.

TL;DR: The food components chlorophyllin, beta-carotene and alpha-linolenic acid (in its methyl ester form) were tested in Chinese hamsters for antimutagenic activity on the powerful mutagen thio-tepa.

TL;DR: Copper sulphate administered intraperitoneally to Swiss albino mice in vivo induced a significant increase in the frequency of chromosomal aberrations in bone marrow cells as all concentrations used when compared to the negative control.

TL;DR: Results suggest that the mutagenic compounds concentrated by Blue Rayon from smokers' urine are aromatic amino compounds.

TL;DR: In this paper, an increase in the 8-hydroxyguanine content of the nucleic acids extracted from isolated mitochondria was associated with an extensive alteration of normal electrophoretic mobility of mitochondrial DNA.

TL;DR: The results indicate that the distribution of mutational events at the hprt locus in irradiated human cells may not only be LET-dependent but dose-dependent, and that deletions involving large regions of the X chromosome surrounding the h PRT locus are rare events.

TL;DR: CASE, a structure-activity relational system, was used to predict the proportion of substances to be carcinogenic and mutagenic among plant pesticides (phytoalexins) and other natural products compared to that of randomly selected chemicals.

TL;DR: Treatment of human lymphocytes with vanadium pentoxide was not found to increase the frequency of structural chromosomal aberrations (CA) and sister-chromatid exchanges (SCE), but V2O5 significantly increased polyploid cell frequency and the mitotic index was significantly decreased.

TL;DR: It is shown that p-tetrachlorohydroquinone (TCH), the metabolite of the environmental chemical pentachlorophenol (PCP), is more toxic to cultured CHO cells than PCP, and that it causes DNA single-strand breaks and/or alkali-labile sites at concentrations of 2-10 microgram/ml as demonstrated by the alkaline elution technique.

TL;DR: The data support a role for oxygen radicals in chromium-mediated mutagenesis and suggests at least two pathways by which chromium compounds can induce mutations.

TL;DR: Results indicate that tannic acid acts as an anticlastogen and antimutagen in vivo.

TL;DR: Cytogenetic damage induced by a wide range of concentrations of uranyl fluoride injected into mouse testes was evaluated by determining the frequencies of chromosomal aberrations in spermatogonia and primary s permatocytes.

TL;DR: It is concluded that, like mitomycin C (Adler, 1976), cisplatin primarily caused aberrations during the premeiotic phase of DNA synthesis.

TL;DR: A micronucleus test in gill cells of the freshwater mussel Anodonta cygnea has been proposed for the detection of drinking water genotoxicity and highly significant increases in spontaneous MN frequency were observed at each sampling.

TL;DR: The intrinsic potential for eliciting mutagenic responses may not be the same for the two enantiomeric forms of epoxystyrene, as there is evidence of qualitative differences in the binding to DNA, pointing strongly to an intrinsic difference inmutagenic activity of theTwo enantiomers.

TL;DR: The progressive increase in the use of aluminium compounds has enhanced the possibility of human exposure and, in spite of its low absorption rate, A1 accumulates in certain tissues, resulting in neurotoxic effects.

TL;DR: The clastogenicity of trimethyltin chloride was evaluated in human peripheral blood lymphocytes with micronucleus counts (MNC) as the endpoint and higher frequencies of MNC enhancement were observed in male individuals than in females.

TL;DR: In 20 out of a total of 23 individuals employed in cyclophosphamide synthesis and manufacturing, the variant frequency of 6-thioguanine-resistant lymphocytes was found to be higher than the maximum individual frequency found in the control population.

TL;DR: In wild-type strains G1/S phase cells were found to be the most sensitive and late S/G2 cells the most resistant and Stationary-phase (G0) cells were significantly more UV resistant than G1 cells.

TL;DR: The high incidence of aberrations could be explained by the exposure to toluene, but the influence of rotogravure printing dyes cannot be excluded.