Showing papers in "Natural Product Reports in 2006"

TL;DR: This review focuses on new endophyte-related findings in biology and ecology, and also summarises the various metabolites isolated from endophytes.

TL;DR: The biosynthetic pathways for several representative terpene indole alkaloids are described in detail, showing a diverse array of structures and biological activities.

TL;DR: The pharmacological activity of naturally occurring triterpenoids excluding the degraded triter penoids and cucurbitacins is reviewed, which includes anticancer, anti-inflammatory, antiulcerogenic, antimicrobial and antiviral activity.

TL;DR: This review covers the recent marine chemical ecology literature for benthic cyanobacteria, macroalgae, sponges, octocorals, molluscs, other benthics invertebrates, fish and seabirds.

TL;DR: 183 compounds obtained from plants and fungi which have been shown to inhibit acetylcholinesterase are described, mainly alkaloids although some meroterpenoids from fungi have also been found to be active and display better selectivity.

TL;DR: This review covers the phytochemistry and pharmacology of naturally occurring phloroglucinols, describing 700 compounds and containing a total of 484 references.

TL;DR: Isodon species (Labiatae) are widely distributed plants, many of which are used in folk medicine, and have received considerable phytochemical and biological attention over the past twenty years.

TL;DR: The focus of this Highlight is primarily on the construction of pyrrole rings during secondary metabolite formation, and on their derivatization and incorporation into natural products.

TL;DR: Saxitoxin has been discovered to also bind to calcium and potassium channels, neuronal nitric oxide synthase, STX metabolizing enzymes and two circulatory fluid proteins, namely a transferrin-like family of proteins and a unique protein found in the blood of pufferfish.

TL;DR: The indolocarbazole family of natural products, including the biosynthetically related bisindolylmaleimides, is reviewed, with an emphasis on the development of analogs that have entered clinical trials for its future use against cancer or other diseases.

TL;DR: Current and future applications of birch bark natural products in pharmaceuticals, cosmetics, and dietary supplements for the prevention and treatment of cancer, HIV, and other human pathogens are reviewed.

TL;DR: A range of sulfur-containing natural products from plants, fungi, bacteria and animals have recently been investigated to determine their therapeutic potential.

TL;DR: This review, with 186 references cited, gives an account of the chemistry and biology of these biologically significant secondary metabolites of terrestrial and marine microorganisms as well as marine invertebrates.

TL;DR: The curious history of kojic acid is reviewed, which was one of the first secondary metabolites to have its biosynthetic pathway studied by the isotope tracer technique, and has been of interest as a skin lightening agent.

TL;DR: This review covers the literature on the subject of biologically active peptide from the glands of amphibians, which include neuropeptides, antimicrobial and anticancer active peptides, antiviral agents, fungicides and peptides which complex with Ca2+ calmodulin.

TL;DR: The chemistry, bioactivity and geographical diversity of steroidal alkaloid isolated from Veratrum and Fritillaria species are summarized to illustrate the chemo-diversity and biological significance of these alkaloids, along with their geographical distribution where this is discernible.

TL;DR: This review primarily aims to provide a comprehensive summary of the major achievements in this and related research areas in China over the last three decades, but also to identify the difficulties and predict future trends in developing plant tissue culture biotechnology for the manufacture of bioactive natural products.

TL;DR: This review covers the structures and biological activities of eudesmane-type sesquiterpenoids from the plants of the Asteraceae family.

TL;DR: This review covers the biosynthesis of aliphatic and aromatic polyketides as well as mixed polyketide/NRPS metabolites, and discusses the molecular genetics and enzymology of the proteins responsible for their formation.

TL;DR: In principle, DNA-mediated charge transfer processes can be categorized as oxidative hole transfer and reductive electron transfer and the transport or transfer of excess electrons has a large potential for biomedical applications, mainly for DNA chip technology.

TL;DR: The extreme environments created by these toxic substances accelerate the evolutionary process and examples of bacteria that have conscripted metabolic enzymes for novel remediatory pathways are included in a discussion of the future of nitroaromatic bioremediation.

TL;DR: The reactions and partial synthesis of estrogens, androgens, pregnanes, bile acid derivatives, cholestanes and vitamin D analogues are covered.

TL;DR: This review discusses the nature and significance of pigments, the chemical and biological processes involved, the factors responsible for and affecting bright colourations, as well as their evolution and speculation as to their function.

TL;DR: This review presents the structure, biological activity and, where applicable, references to the syntheses of 154 spongeian and rearranged spongian diterpenoids isolated from marine sponges of the orders Dictyoceratida and Dendroceratida.

TL;DR: In this article, a review of linear furano- and pyrroloterpenoids, together with their relevant biological activities, source organisms and country of origin, is presented, and the first total syntheses that lead to the revision of structures or stereochemistries have been included, and 206 references are cited.

TL;DR: A review of the existing literature on the occurrence, isolation, biosynthetic origins and mode of action of strigolactones, and the methods for their synthesis can be found in this paper.

TL;DR: A general survey of natural product databases, suppliers and manufacturers describes opportunities for researchers to obtain information about natural compounds and makes a proposal for successful identification of pharmaceutically relevant substances.

TL;DR: The development of biosynthesis knowledge over the past half-century is discussed, with emphasis on the relatively recent contributions of molecular biology to the elucidation of these biosynthetic pathways.

TL;DR: This review serves as an introduction into the application of electrospray ionization Fourier-Transform massspectrometry (ESI-FTMS) to investigate NRPS and PKS systems, the first review devoted to this methodology.

TL;DR: This Highlight focuses on reactions involved in cofactor biosynthesis that pose interesting mechanistic problems and are likely to pose problems in the coming years.